GSM3940474[Accession] - GEO DataSets

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Items: 4

Select item 2001342531.

Muscle-secreted G-CSF as a metabolic niche factor ameliorates loss of muscle stem cell in aged mice

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Mus musculus

Type:: Genome binding/occupancy profiling by high throughput sequencing; Expression profiling by high throughput sequencing

Platform:: GPL24247
9 Samples

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Series

Accession:: GSE134253

ID:: 200134253

PubMed Full text in PMC Similar studies

Select item 2001342522.

Muscle-secreted G-CSF as a metabolic niche factor ameliorates loss of muscle stem cell in aged mice (RNA-seq)

(Submitter supplied) Function and number of muscle stem cells (satellite cells, SCs) declines with muscle aging. Although SCs are heterogeneous and different subpopulations have been identified, it remains unknown if a specific subpopulation of muscle SCs selectively decreases during aging. Here, we find Pax7Hi cells are dramatically reduced in aged mice and this aged-dependent loss of Pax7Hi cells is metabolically mediated by myofiber-secreted granulocyte-colony stimulating factor G-CSF as the Pax7Hi SCs are replenished by exercise-induced G-CSF in aged mice. more...