GEO DataSets

(Submitter supplied) The main goal of this study is to integrate gene expression analysis with ChIP-chip study. To examine the relationship between promoter occupancy and gene expression, we transiently depleted p53 and p73 via small interfering RNA (siRNA) in HCT116-3(6) cells and then performed microarray analysis of 32,000 genes before or after HU treatment using the Phalanx expression array platform. We found that only 6%-14% of p53 and p73 bound promoters at FDRMAP <0.05 exhibited significant changes in mRNA expression when p53 and p73 were simultaneously knocked-down by siRNA. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL6254

16 Samples

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(Submitter supplied) Phalanx Biotech Group's Human OneArray contains 32,048 features, 30968 detection probes and 1080 control probes, spotted onto glass slides using a proprietary non-contact printing method. Detection probes are annotated against the human genome and grouped into the following categories: Group 1 - gene specific: exon Group 2 - intron hit Group 3 - intergenic Group 4 - multi-gene hits Group 5 - no hit to genome Group 6 - >200 hits to genome Protocol: See http://www.phalanxbiotech.com/ for updated protocols

Organism:

Homo sapiens

41 Series

2 Related Platforms

653 Samples

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