GSM3057422[Accession] - GEO DataSets

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Items: 4

Select item 2001120971.

Role of SmcHD1 in the establishment of the epigenetic states required for the maintenance of X chromosome inactivation

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing

Platforms:: GPL18480 GPL11002
8 Samples

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Series

Accession:: GSE112097

ID:: 200112097

PubMed Similar studies

Select item 2001120962.

Role of SmcHD1 in the establishment of the epigenetic states required for the maintenance of X chromosome inactivation [ChIP-seq]

(Submitter supplied) It has been shown that functional deficiency of SmcHD1, a noncanonical member of SMC family proteins, results in derepression of X-inactivated genes in postimplantation female mouse embryos. In this study, we found that derepression of X-inactivated genes accompanied a local reduction in the enrichment of H3K27me3 in mouse embryonic fibroblasts (MEFs) prepared from female fetuses deficient for SmcHD1.