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Items: 4

1.

Chromatin mapping and single-cell immune profiling defines the temporal dynamics of ibrutinib drug response in chronic lymphocytic leukemia

(Submitter supplied) Chronic lymphocytic leukemia (CLL) is a genetically, epigenetically, and clinically heterogeneous disease. Despite this heterogeneity, the Bruton tyrosine kinase (BTK) inhibitor ibrutinib provides effective treatment for the vast majority of CLL patients. To define the underlining regulatory program, we analyzed high-resolution time courses of ibrutinib treatment in closely monitored patients, combining cellular phenotyping (flow cytometry), single-cell transcriptome profiling (scRNA-seq), and chromatin mapping (ATAC-seq). more...
Organism:
Homo sapiens
Type:
Genome binding/occupancy profiling by high throughput sequencing; Expression profiling by high throughput sequencing
Platform:
GPL20301
188 Samples
Download data: BIGWIG, NARROWPEAK
Series
Accession:
GSE111015
ID:
200111015

PubMed Full text in PMC Similar studies

2.

Chromatin mapping and single-cell immune profiling defines the temporal dynamics of ibrutinib drug response in chronic lymphocytic leukemia [ATAC-seq]

(Submitter supplied) Chronic lymphocytic leukemia (CLL) is a genetically, epigenetically, and clinically heterogeneous disease. Despite this heterogeneity, the Bruton tyrosine kinase (BTK) inhibitor ibrutinib provides effective treatment for the vast majority of CLL patients. To define the underlining regulatory program, we analyzed high-resolution time courses of ibrutinib treatment in closely monitored patients, combining cellular phenotyping (flow cytometry), single-cell transcriptome profiling (scRNA-seq), and chromatin mapping (ATAC-seq). more...
Organism:
Homo sapiens
Type:
Genome binding/occupancy profiling by high throughput sequencing
Platform:
GPL20301
176 Samples
Download data: BIGWIG, NARROWPEAK
Series
Accession:
GSE111013
ID:
200111013

PubMed Full text in PMC Similar studies SRA Run Selector

3.

Illumina HiSeq 4000 (Homo sapiens)

Organism:
Homo sapiens
8004 Series
184359 Samples
Download data
Platform
Accession:
GPL20301
ID:
100020301

4.

ATAC-seq on PBMCs from patient CLL7 on day 3 of ibrutinib treatment, CD8 cells

Organism:
Homo sapiens
Source name:
PBMCs_CLL patient_day 3 of ibrutinib treatment_CD8 cells
Platform:
GPL20301
Series:
GSE111013 GSE111015
Download data: BIGWIG, NARROWPEAK
Sample
Accession:
GSM3020368
ID:
303020368

SRA Run Selector

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db=gds|term=GSM3020368[Accession]|query=1|qty=2|blobid=MCID_662a6c76f436486715664a80|ismultiple=true|min_list=5|max_list=20|def_tree=20|def_list=|def_view=|url=/Taxonomy/backend/subset.cgi?|trace_url=/stat?
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