GEO DataSets

(Submitter supplied) Chromatin organization undergoes drastic reprogramming during gametogenesis . However, the three-dimensional chromatin structure and its reprogramming remain largely unknown, with even less known for primates. Here, by using a low-input Hi-C method we developed recently, we examined re-organization of 3D chromatin architecture during spermatogenesis in rhesus monkey (Macaca mulatta). Interestingly, we found that topologically associating domains (TADs) are partially dissolved in spermatogonia and are further depleted at the pachytene stage, before they gradually become consolidated in round spermatids and mature sperm. more...

Organism:

Mus musculus; Macaca mulatta

Type:

Other; Methylation profiling by high throughput sequencing; Expression profiling by high throughput sequencing

Platforms:

GPL21273 GPL19129 GPL24522

35 Samples

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