GEO DataSets

(Submitter supplied) Obesity, a prevalent condition in adults and children, impairs bone marrow (BM) function. However, the underlying mechanisms are unclear. Here we show that obese mice exhibit poor emergency immune responses in a toll-like receptor 4 (TLR4)-dependent manner. Canonical myeloid genes (Csf1r, Spi1, Runx1) are enhanced, and lymphoid genes (Flt3, Tcf3, Ebf1) are reduced. Using adoptive transfer and mixed BM chimera approaches we demonstrate that myeloid>lymphoid bias arises after six weeks of high fat diet and depends on precursor cell-autonomous TLR4. more...

Organism:

Homo sapiens; Mus musculus

Type:

Other

Platform:

GPL24518

11 Samples

Download data: RCC, XLSX

(Submitter supplied) See manufacturer's website http://www.nanostring.com

Organism:

Homo sapiens

1 Series

11 Samples

Download data