GSM2739371[Accession] - GEO DataSets

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Items: 4

Select item 2001024901.

A somatic role for the histone methyltransferase Setdb1 in endogenous retrovirus silencing

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL18480
34 Samples

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Series

Accession:: GSE102490

ID:: 200102490

PubMed Full text in PMC Similar studies

Select item 2001024862.

A somatic role for the histone methyltransferase Setdb1 in endogenous retrovirus silencing [RNA-Seq]

(Submitter supplied) Subsets of endogenous retroviruses (ERVs) are derepressed in mouse embryonic stem cells (mESCs) deficient for Setdb1, which catalyzes histone H3 lysine 9 trimethylation (H3K9me3). Most of those ERVs, including IAPs, remain silent if Setdb1 is deleted in differentiated embryonic cells; however they are derepressed when deficient for Dnmt1, suggesting that Setdb1 is dispensable for ERV silencing in somatic cells. more...