GSM2714336[Accession] - GEO DataSets

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Items: 4

Select item 2001117061.

Metastasis in triple-negative breast cancer

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing; Genome variation profiling by SNP array

Platforms:: GPL13829 GPL18460
24 Samples

Download data: IDAT

Series

Accession:: GSE111706

ID:: 200111706

PubMed Full text in PMC Similar studies

Select item 2001017452.

Functional and genomic characterization of a xenograft model system for the study of metastasis in triple-negative breast cancer.

(Submitter supplied) To define the molecular regulators of metastasis of triple-negative breast cancer, we conducted a rigorous characterization of four isogenic populations of MDA-MB-231 human triple-negative breast cancer cells that display a range of intrinsic spontaneous metastatic capacities in immuno-deficient mice, from non-metastatic to highly metastatic to lung, liver, spleen and spine. PAT-Seq gene expression profiling of primary tumor cells identified the fibroblast growth factor homologous factor, FGF13, as a candidate metastatic virulence gene highly upregulated in aggressively metastatic MDA-MB-231HM tumors.