GSM2581136[Accession] - GEO DataSets

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Items: 4

Select item 2000979261.

Western diet triggers NLRP3-dependent persistent functional reprogramming of myeloid cells

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Mus musculus

Type:: Genome binding/occupancy profiling by high throughput sequencing; Expression profiling by high throughput sequencing

Platform:: GPL18480
48 Samples

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Accession:: GSE97926

ID:: 200097926

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Select item 2000979252.

Western diet triggers NLRP3-dependent persistent functional reprogramming of myeloid cells [RNA-Seq]

(Submitter supplied) Here we investigated whether sterile triggers of inflammation induce trained immunity and thereby influence innate immune responses. Western diet (WD) feeding of Ldlr-/- mice induced systemic inflammation, which was undectable in serum soon after mice were shifted back to chow diet (CD). In contrast, myeloid cell responses towards innate stimuli remained broadly augmented. WD induced transcriptomic and epigenomic reprogramming of myeloid progenitor cells, leading to increased proliferation as well as enhanced innate immune and interferon responses towards in vivo LPS challenge. more...