GSM2443966[Accession] - GEO DataSets

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Items: 4

Select item 2001050571.

Transcription factor Hoxb5 reprograms B cells into functional T lymphocytes

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing

Platforms:: GPL19057 GPL21273
94 Samples

Download data: BW

Series

Accession:: GSE105057

ID:: 200105057

PubMed Full text in PMC Similar studies

Select item 2000931072.

Transcription factor Hoxb5 reprograms B cells into functional T lymphocytes [RNA-Seq]

(Submitter supplied) Natural hematopoietic stem cells are currently the only cell resource to generate entire T lymphopoiesis in vivo. Altenatively, functional and non-tumorigenic T lymphocytes converted from the other cell types remain unsuccessful. Evidence is still lacking about the concept that 'lineage-switching factors' (LSFs) exist in HSC, whose re-activation in progeny cells can accomplish lineage conversions. Here we show that upon ectopic expression of Hoxb5(a HSC-specific transcription factor), the Pro-/Pre-B cells were induced into functional early T cell progenitors(iETPs) in vivo. more...