GSM2303139[Accession] - GEO DataSets

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Items: 4

Select item 2000864731.

Single cell transcriptomics defines human islet cell signatures and reveals cell-type-specific expression changes in type 2 diabetes

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below. Grant ID: Award No. W81XWH-16-1-0130 Grant title: Peer Reviewed Medical Research Program Funding Source: Assistant Secretary of Defense for Health Affairs Affiliation: Jackson Laboratory for Genomic Medicine, Farmington, CT Name: Michael Stitzel

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL18573
662 Samples

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Accession:: GSE86473

ID:: 200086473

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 2000864682.

Single cell transcriptomics defines human islet cell signatures and reveals cell-type-specific expression changes in type 2 diabetes [bulk]

(Submitter supplied) Blood glucose levels are tightly controlled by the coordinated action of at least five cell types constituting pancreatic islets. Changes in the proportion and/or function of these cells are associated with genetic and molecular pathophysiology of monogenic, type 1, and type 2 diabetes (T2D). Cellular heterogeneity impedes precise understanding of the molecular components of each islet cell type that govern islet dysfunction, particularly the less abundant delta and gamma/pancreatic polypeptide (PP) cells. more...