(Submitter supplied) The post-transcriptional addition of nucleotides to the 3´ end of RNA regulates the maturation, function, and stability of RNA species in all domains of life. Here, we show that, in flies, 3´ terminal RNA uridylation triggers the processive, 3´-to-5´ exoribonucleolytic decay via the RNase II/R enzyme CG16940, a homolog of the human Perlman syndrome exoribonuclease Dis3l2. Together with the TUTase Tailor, dmDis3l2 forms the cytoplasmic, uridylation-triggered RNA processing (TRUMP) complex, that functionally cooperates in the degradation of structured RNA.
more...- Organism:
- Drosophila melanogaster; synthetic construct
- Type:
- Expression profiling by high throughput sequencing; Non-coding RNA profiling by high throughput sequencing; Other
- Platforms:
- GPL19604 GPL17275
- 15 Samples
Download data: TXT, XLSX