GSM2214067[Accession] - GEO DataSets

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Items: 4

Select item 2000837281.

Epigenetic Lanscape and BRD4 Transcriptional Dependency of PAX3-FOXO1 Driven Rhabdomyosarcoma

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing; Other

Platforms:: GPL11154 GPL18573
80 Samples

Download data: BED, BEDGRAPH, FPKM_TRACKING

Series

Accession:: GSE83728

ID:: 200083728

PubMed Full text in PMC Similar studies

Select item 2000837242.

PAX3-FOXO1 requires BRD4 to drive oncogene addiction in RMS cells [RNA-seq]

(Submitter supplied) The fusion transcription factor PAX3-FOXO1 drives oncogenesis in a subset of rhabdomyosarcomas, however the mechanisms by which it remodels chromatin are unknown. We find PAX3-FOXO1 reprograms the cis-regulatory landscape by inducing super enhancers (SEs), in collaboration with master transcription factors MYOG, MYOD and MYCN. This myogenic SE circuitry is consistent across cell lines and primary tumors. more...