GSM2193309[Accession] - GEO DataSets

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Items: 4

Select item 2000831281.

Oncogenic ZEB2 activation drives sensitivity towards LSD1 inhibition in T-cell acute lymphoblastic leukemia

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Mus musculus; Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platforms:: GPL18480 GPL18573
48 Samples

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Accession:: GSE83128

ID:: 200083128

PubMed Full text in PMC Similar studies

Select item 2000831262.

Effect of 48h treatment with 100nM GSK2879552 on T-ALL cell lines LOUCY and PEER

(Submitter supplied) RNA sequencing was performed on biological triplicates of LOUCY and PEER cells treated with 100nM GSK2879552 for 48h versus their corresponding DMSO treatment controls. GSK2879552 is a potent, selective and orally bioavailable inhibitor of the lysine-specific histone demethylase 1 (LSD1). Gene expression was severely affected by LSD1 inhibition. Pathway analysis performed on the differentially expressed genes following 48hrs of LSD1i treatment clearly showed an increased apoptotic gene signature (CASP3, CASP8) and enhanced expression of genes associated with TRAIL signaling. more...