GEO DataSets

(Submitter supplied) Activation-induced cytidine deaminase (AID) is a B-cell specific enzyme that targets immunoglobulin (Ig) genes to initiate class switch recombination (CSR) and somatic hypermutation (SHM). Through off-target activity, however, AID has a much broader impact on genomic instability by initiating oncogenic chromosomal translocations and mutations involved in lymphoma development and progression. AID expression is tightly regulated in B cells and its overexpression leads to enhanced genomic instability and lymphoma formation. more...

Organism:

Mus musculus; Homo sapiens

Type:

Other; Expression profiling by high throughput sequencing

Platforms:

GPL15520 GPL16417 GPL13112

162 Samples

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