GSM1942643[Accession] - GEO DataSets

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Items: 4

Select item 2000751161.

Segmental chromosomal imbalances arise at high frequency in human fibroblasts

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Genome variation profiling by array; SNP genotyping by SNP array

Platforms:: GPL21146 GPL13829
262 Samples

Download data: GPR, IDAT

Series

Accession:: GSE75116

ID:: 200075116

Analyze with GEO2R

Select item 2000750982.

Segmental chromosomal imbalances arise at high frequency in human fibroblasts (SB_sc_2)

(Submitter supplied) Preservation of chromosome integrity is key for the survival of any organism. To assure segregation of intact chromosomes, cell division is presumed to be under strict control of cell-cycle checkpoints. Estimates of chromosomal mutation rates per generation based on cytogenetic analyses of newborns and products of conception, range between 4.57x10-5 and 3.42x10-4. In contrast, the high incidence of segmental imbalances detected by single-cell genome-wide copy number profiling indicates that the error rate per cell division might be more than an order of magnitude higher. more...