GSM1858634[Accession] - GEO DataSets

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Items: 4

Select item 2000722521.

DNaseI hypersensitivity assay and ER, GR, and FoxA1 binding patterns in breast cancer cells

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platforms:: GPL18573 GPL11154
57 Samples

Download data: BEDGRAPH

Series

Accession:: GSE72252

ID:: 200072252

PubMed Full text in PMC Similar studies

Select item 2000722492.

Characterization of ER, GR, and FoxA1 binding patterns in breast cancer cells treated with either Dex or E2

(Submitter supplied) The estrogen receptor (ER), glucocorticoid receptor (GR), and forkhead box protein 1 (FoxA1) are significant factors in breast cancer progression. FoxA1 is well-established as a pioneer factor for steroid receptor recruitment to chromatin. Here we show that ER and GR have the ability to alter the genomic response of FoxA1 to specific binding sites within the genome. These findings alter the classical understood mechanism of FoxA1 establishing a dynamic transcription factor that can be regulated by hormones.