GEO DataSets

(Submitter supplied) Background: Mesenchymal stem cells (MSCs) and macrophages are fundamental components of the stem cell niche and function coordinately to regulate hematopoietic stem cell self-renewal and mobilization. Recent studies indicate that mitophagy and healthy mitochondrial function are critical to the survival of stem cells but how these processes are regulated in MSCs is unknown. Here we show that MSCs manage intracellular oxidative stress by targeting depolarized mitochondria to the plasma membrane via arrestin domain-containing protein 1-mediated microvesicles , which are then engulfed and re-utilized via a process involving fusion by macrophages resulting in enhanced bio-energetics. more...

Organism:

Homo sapiens

Type:

Non-coding RNA profiling by array

Platform:

GPL18743

18 Samples

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(Submitter supplied) Table corresponds to miRNA_107_Sep09 Agilent Feature Extraction file. Protocol: See manufacturer's web site at http://www.agilent.com/

Organism:

Homo sapiens

3 Series

49 Samples

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