GSM1678959[Accession] - GEO DataSets

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Items: 4

Select item 2000686831.

Cell density, Her2 and progesterone signaling regulate dissemination of breast cancer cells

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Mus musculus

Type:: Non-coding RNA profiling by high throughput sequencing; Expression profiling by array

Platforms:: GPL13188 GPL16417
58 Samples

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Series

Accession:: GSE68683

ID:: 200068683

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000686812.

Cell density, Her2 and progesterone signaling regulate dissemination of breast cancer cells [Gene expression]

(Submitter supplied) Disseminated breast cancer cells display genotypes disparate from the predominant clone of the primary tumor before manifestation of metastasis, suggesting that cancer cell dissemination occurs preferentially early; however, the underlying molecular mechanisms are unknown. Investigating metastasis in a Her2-driven mouse model, we found that the progesterone-induced paracrine cytokines Wnt4 and Rankl induced migration and early dissemination shortly after Her2 activation. more...