GSM1246566[Accession] - GEO DataSets

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Items: 4

Select item 2000515341.

The THO complex regulates pluripotency gene mRNA export to control embryonic stem cell self-renewal and somatic cell reprogramming

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Mus musculus

Type:: Expression profiling by array; Expression profiling by high throughput sequencing

Platforms:: GPL4134 GPL16417
8 Samples

Download data: BW, TXT

Series

Accession:: GSE51534

ID:: 200051534

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000514962.

The THO complex regulates pluripotency gene mRNA export to control embryonic stem cell self-renewal and somatic cell reprogramming (microarray)

(Submitter supplied) Embryonic stem cell (ESC) self-renewal and differentiation are governed by a broad-ranging regulatory network. Although the transcriptional regulatory mechanisms involved have been investigated extensively, post-transcriptional regulation is still poorly understood. Here we describe a critical role of the THO complex in ESC self-renewal and differentiation. We show that THO preferentially interacts with pluripotency gene transcripts through Thoc5, and is required for self-renewal at least in part by regulating their export and expression. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL4134
6 Samples

Download data: TXT

Series

Accession:: GSE51496

ID:: 200051496

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 1000041343.

Agilent-014868 Whole Mouse Genome Microarray 4x44K G4122F (Feature Number version)

(Submitter supplied) Designed to truly represent all known genes in the mouse genome and their resulting transcripts, Agilent's Whole Mouse Genome Oligo – 4X44K microarray is comprised of 41,534 60-mer oligonucleotide probes representing over 41,000 mouse genes and transcripts. Content for this microarray was generated from leading public databases, including RefSeq, RIKEN, NIA, Ensembl, RIKEN, UCSC Goldenpath, and Unigene. more...