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Items: 3

1.

Genome-wide epigenetic analyses and Transcriptional analysis in NB4 cells expressing PML-RARalpha

(Submitter supplied) Illumina High-Throughput ChIP Sequencing profiling was performed using the H3K9K14ac antibody in NB4 cells treated with the compounds ATRA, MS-275,MC2392 (a hybrid molecule of ATRA with a 2-aminoanilide tail of the HDAC inhibitor MS-275) or solvent, DMSO. We find that MC2392 induces changes in H3 acetylation at a small subset of PML-RARα binding sites but also in regions not regulated by ATRA. Moreover, MC2392 alters expression of a number of stress-responsive and apoptotic genes.
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing
Platforms:
GPL9052 GPL10999
12 Samples
Download data: BED, WIG
Series
Accession:
GSE50958
ID:
200050958
2.

Illumina Genome Analyzer (Homo sapiens)

Platform
Accession:
GPL9052
ID:
100009052
3.

NB4_MC2392_48h_ChIP_Seq

Organism:
Homo sapiens
Source name:
MC2392 treated NB4 cells, 48h ChIP
Platform:
GPL9052
Series:
GSE50958
Download data: BED, WIG
Sample
Accession:
GSM1233298
ID:
301233298
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db=gds|term=GSM1233298[Accession]|query=1|qty=2|blobid=MCID_685a3b73a711e52e1a9a1a83|ismultiple=true|min_list=5|max_list=20|def_tree=20|def_list=|def_view=|url=/Taxonomy/backend/subset.cgi?|trace_url=/stat?
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