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Items: 10

1.

Lkb1 inactivation drives lung cancer lineage switching governed by Polycomb Repressive Complex 2

(Submitter supplied) Adenosquamous lung tumors may result from cellular plasticity. We demonstrate lineage switching of KRAS+ lung adenocarcinomas (ADC) to squamous cell carcinoma (SCC) through deletion of Lkb1 (Stk11) in autochthonous and transplant models. Chromatin analysis reveals loss of H3K27me3 and gain of H3K27ac and H3K4me3 at squamous lineage genes, included Sox2, ΔNp63 and Ngfr. SCC lesions have higher levels of the H3K27 methyltransferase EZH2 than the ADC lesions, but there is a clear lack of the essential Polycomb Repressive Complex 2 (PRC2) subunit EED in the SCC lesions.
Organism:
Mus musculus
Type:
Genome binding/occupancy profiling by high throughput sequencing
Platform:
GPL19057
8 Samples
Download data: BED, WIG
Series
Accession:
GSE94365
ID:
200094365

PubMed Full text in PMC Similar studies SRA Run Selector

2.

Illumina NextSeq 500 (Mus musculus)

Organism:
Mus musculus
10757 Series
306027 Samples
Download data
Platform
Accession:
GPL19057
ID:
100019057

3.

SCC_input

Organism:
Mus musculus
Source name:
Lung tumors
Platform:
GPL19057
Series:
GSE94365
Download data
Sample
Accession:
GSM2474144
ID:
302474144

SRA Run Selector

4.

ADC_input

Organism:
Mus musculus
Source name:
Lung tumors
Platform:
GPL19057
Series:
GSE94365
Download data
Sample
Accession:
GSM2474143
ID:
302474143

SRA Run Selector

5.

SCC_H3K27me3_ChIPSeq

Organism:
Mus musculus
Source name:
Lung tumors
Platform:
GPL19057
Series:
GSE94365
Download data: WIG
Sample
Accession:
GSM2474142
ID:
302474142

SRA Run Selector

6.

ADC_H3K27me3_ChIPSeq

Organism:
Mus musculus
Source name:
Lung tumors
Platform:
GPL19057
Series:
GSE94365
Download data: WIG
Sample
Accession:
GSM2474141
ID:
302474141

SRA Run Selector

7.

SCC_H3K27Ac_ChIPSeq

Organism:
Mus musculus
Source name:
Lung tumors
Platform:
GPL19057
Series:
GSE94365
Download data: BED
Sample
Accession:
GSM2474140
ID:
302474140

SRA Run Selector

8.

ADC_H3K27Ac_ChIPSeq

Organism:
Mus musculus
Source name:
Lung tumors
Platform:
GPL19057
Series:
GSE94365
Download data: BED
Sample
Accession:
GSM2474139
ID:
302474139

SRA Run Selector

9.

SCC_H3K4me3_ChIPSeq

Organism:
Mus musculus
Source name:
Lung tumors
Platform:
GPL19057
Series:
GSE94365
Download data: BED
Sample
Accession:
GSM2474138
ID:
302474138

SRA Run Selector

10.

ADC_H3K4me3_ChIPSeq

Organism:
Mus musculus
Source name:
Lung tumors
Platform:
GPL19057
Series:
GSE94365
Download data: BED
Sample
Accession:
GSM2474137
ID:
302474137

SRA Run Selector

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db=gds|term=GSE94365[Accession]|query=1|qty=2|blobid=MCID_68033f3de4d5e36a862b9e4d|ismultiple=true|min_list=5|max_list=20|def_tree=20|def_list=|def_view=|url=/Taxonomy/backend/subset.cgi?|trace_url=/stat?
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