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Items: 11

1.

Protracted NP95 binding to hemimethylated DNA disrupts SETDB1-mediated proviral silencing [ChIP-seq]

(Submitter supplied) Genetic ablation of the maintenance methyltransferase Dnmt1 induces widespread demethylation and transcriptional activation of CpG-rich IAP (intracisternal A particle) proviruses. Here, we report that this phenomenon is not simply a consequence of loss of DNA methylation. By exploiting conditional deletions of Dnmt1 and Np95, each of which is essential for maintenance methylation, we find that while IAPs are indeed de-repressed in Dnmt1-ablated embryos and embryonic stem cells (ESCs), these proviruses remain silenced in Np95-ablated cells, despite similar kinetics of passive demethylation. more...
Organism:
Mus musculus
Type:
Genome binding/occupancy profiling by high throughput sequencing
Platform:
GPL18480
9 Samples
Download data: WIG
Series
Accession:
GSE77779
ID:
200077779

PubMed Similar studies SRA Run Selector

2.

Illumina HiSeq 1500 (Mus musculus)

Organism:
Mus musculus
627 Series
11648 Samples
Download data
Platform
Accession:
GPL18480
ID:
100018480

3.

Np95cKO ESC, replicate 1 [ChIP-seq]

Organism:
Mus musculus
Source name:
ES cells
Platform:
GPL18480
Series:
GSE77779 GSE77781
Download data: WIG
Sample
Accession:
GSM2059188
ID:
302059188

SRA Run Selector

4.

Np95 wt ESC, replicate 1 [ChIP-seq]

Organism:
Mus musculus
Source name:
ES cells
Platform:
GPL18480
Series:
GSE77779 GSE77781
Download data: WIG
Sample
Accession:
GSM2059187
ID:
302059187

SRA Run Selector

5.

Np95cKO ESC, Input [ChIP-seq]

Organism:
Mus musculus
Source name:
ES cells
Platform:
GPL18480
Series:
GSE77779 GSE77781
Download data: WIG
Sample
Accession:
GSM2059186
ID:
302059186

SRA Run Selector

6.

Np95 wt ESC, Input [ChIP-seq]

Organism:
Mus musculus
Source name:
ES cells
Platform:
GPL18480
Series:
GSE77779 GSE77781
Download data: WIG
Sample
Accession:
GSM2059185
ID:
302059185

SRA Run Selector

7.

Np95cKO ESC [ChIP-seq]

Organism:
Mus musculus
Source name:
ES cells
Platform:
GPL18480
Series:
GSE77779 GSE77781
Download data: WIG
Sample
Accession:
GSM2059184
ID:
302059184

SRA Run Selector

8.

Np95 wt ESC [ChIP-seq]

Organism:
Mus musculus
Source name:
ES cells
Platform:
GPL18480
Series:
GSE77779 GSE77781
Download data: WIG
Sample
Accession:
GSM2059183
ID:
302059183

SRA Run Selector

9.

Myc-Dnmt1 wt ESC [ChIP-seq]

Organism:
Mus musculus
Source name:
ES cells
Platform:
GPL18480
Series:
GSE77779 GSE77781
Download data: WIG
Sample
Accession:
GSM2059182
ID:
302059182

SRA Run Selector

10.

DN+Myc-Np95 wt ESC [ChIP-seq]

Organism:
Mus musculus
Source name:
ES cells
Platform:
GPL18480
Series:
GSE77779 GSE77781
Download data: WIG
Sample
Accession:
GSM2059181
ID:
302059181

SRA Run Selector

11.

DN+Myc-Np95 cDKO ESC [ChIP-seq]

Organism:
Mus musculus
Source name:
ES cells
Platform:
GPL18480
Series:
GSE77779 GSE77781
Download data: WIG
Sample
Accession:
GSM2059180
ID:
302059180

SRA Run Selector

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db=gds|term=GSE77779[Accession]|query=1|qty=2|blobid=MCID_685b3f92a711e52e1ae42caf|ismultiple=true|min_list=5|max_list=20|def_tree=20|def_list=|def_view=|url=/Taxonomy/backend/subset.cgi?|trace_url=/stat?
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