GSE70874[Accession] - GEO DataSets - NCBI

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Items: 14

Select item 2000708741.

Spontaneous single-copy loss of TP53 in human embryonic stem cells markedly increases cell proliferation and survival [RNA-Seq]

(Submitter supplied) The potential safety issues related to the acquisition of common genomic aberrations in hPSC cultures are well-recognized, but these risks have not been evaluated for sporadic mutations. Here, we explore whether a sporadic mutation that spontaneously arose in a hESC culture consisting of a single-copy deletion of chr17p13.1 would confer a survival advantage to the mutant cells. Compared to wild-type cells with two normal copies of the chr17p13.1 region, the mutant cells displayed a selective advantage when exposed to stressful conditions, and retained a higher percentage of pluripotent cells after two weeks of in vitro differentiation. more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL16791
12 Samples

Download data: XLSX

Series

Accession:: GSE70874

ID:: 200070874

PubMed Similar studies SRA Run Selector

Select item 1000167912.

Illumina HiSeq 2500 (Homo sapiens)

Organism:: Homo sapiens

12448 Series
356115 Samples

Platform

Accession:: GPL16791

ID:: 100016791

Select item 3018210133.

Organism:: Homo sapiens

Source name:: Wild-type2_3

Platform:: GPL16791
Series:: GSE70874 GSE70875

Sample

Accession:: GSM1821013

ID:: 301821013

SRA Run Selector

Select item 3018210124.

Organism:: Homo sapiens

Source name:: Wild-type2_2

Platform:: GPL16791
Series:: GSE70874 GSE70875

Sample

Accession:: GSM1821012

ID:: 301821012

SRA Run Selector

Select item 3018210115.

Organism:: Homo sapiens

Source name:: Wild-type2_1

Platform:: GPL16791
Series:: GSE70874 GSE70875

Sample

Accession:: GSM1821011

ID:: 301821011

SRA Run Selector

Select item 3018210106.

Organism:: Homo sapiens

Source name:: Wild-type1_3

Platform:: GPL16791
Series:: GSE70874 GSE70875

Sample

Accession:: GSM1821010

ID:: 301821010

SRA Run Selector

Select item 3018210097.

Organism:: Homo sapiens

Source name:: Wild-type1_2

Platform:: GPL16791
Series:: GSE70874 GSE70875

Sample

Accession:: GSM1821009

ID:: 301821009

SRA Run Selector

Select item 3018210088.

Organism:: Homo sapiens

Source name:: Wild-type1_1

Platform:: GPL16791
Series:: GSE70874 GSE70875

Sample

Accession:: GSM1821008

ID:: 301821008

SRA Run Selector

Select item 3018210079.

Organism:: Homo sapiens

Source name:: Mutant1_3

Platform:: GPL16791
Series:: GSE70874 GSE70875

Sample

Accession:: GSM1821007

ID:: 301821007

SRA Run Selector

Select item 30182100610.

Organism:: Homo sapiens

Source name:: Mutant1_2

Platform:: GPL16791
Series:: GSE70874 GSE70875

Sample

Accession:: GSM1821006

ID:: 301821006

SRA Run Selector

Select item 30182100511.

Organism:: Homo sapiens

Source name:: Mutant1_1

Platform:: GPL16791
Series:: GSE70874 GSE70875

Sample

Accession:: GSM1821005

ID:: 301821005

SRA Run Selector

Select item 30182100412.

Organism:: Homo sapiens

Source name:: Mutant2_3

Platform:: GPL16791
Series:: GSE70874 GSE70875

Sample

Accession:: GSM1821004

ID:: 301821004

SRA Run Selector

Select item 30182100313.

Organism:: Homo sapiens

Source name:: Mutant2_2

Platform:: GPL16791
Series:: GSE70874 GSE70875

Sample

Accession:: GSM1821003

ID:: 301821003

SRA Run Selector

Select item 30182100214.

Organism:: Homo sapiens

Source name:: Mutant2_1

Platform:: GPL16791
Series:: GSE70874 GSE70875

Sample

Accession:: GSM1821002

ID:: 301821002

SRA Run Selector

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