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Items: 8

1.

Pluripotency transcription factor Oct4 mediates stepwise nucleosome demethylation and depletion

(Submitter supplied) The mechanisms whereby the crucial pluripotency transcription factor Oct4 regulates target gene expression are incompletely understood. Using an assay system based on partially differentiated embryonic stem cells, we show that Oct4 opposes accumulation of local H3K9me2, and subsequent Dnmt3a-mediated DNA methylation. Upon binding DNA, Oct4 recruits the histone lysine demethylase Jmjd1c. ChIP timecourse experiments identify a stepwise Oct4 mechanism involving Jmjd1c recruitment and H3K9me2 demethylation, transient FACT complex recruitment, and nucleosome depletion. more...
Organism:
Mus musculus
Type:
Genome binding/occupancy profiling by high throughput sequencing
Platform:
GPL9250
6 Samples
Download data: TDF, XLSX
Series
Accession:
GSE65192
ID:
200065192

PubMed Full text in PMC Similar studies SRA Run Selector

2.

Illumina Genome Analyzer II (Mus musculus)

Organism:
Mus musculus
804 Series
5973 Samples
Download data
Platform
Accession:
GPL9250
ID:
100009250

3.

10 hr Input

Organism:
Mus musculus
Source name:
embryonic stem cells
Platform:
GPL9250
Series:
GSE65192
Download data: TDF
Sample
Accession:
GSM1588969
ID:
301588969

SRA Run Selector

4.

0 hr Input

Organism:
Mus musculus
Source name:
embryonic stem cells
Platform:
GPL9250
Series:
GSE65192
Download data: TDF
Sample
Accession:
GSM1588968
ID:
301588968

SRA Run Selector

5.

Jmjd1c-10hr_ChIPSeq

Organism:
Mus musculus
Source name:
embryonic stem cells
Platform:
GPL9250
Series:
GSE65192
Download data: TDF
Sample
Accession:
GSM1588967
ID:
301588967

SRA Run Selector

6.

Spt16-10hr_ChIPSeq

Organism:
Mus musculus
Source name:
embryonic stem cells
Platform:
GPL9250
Series:
GSE65192
Download data: TDF
Sample
Accession:
GSM1588966
ID:
301588966

SRA Run Selector

7.

Oct4-10hr_ChIPSeq

Organism:
Mus musculus
Source name:
embryonic stem cells
Platform:
GPL9250
Series:
GSE65192
Download data: TDF
Sample
Accession:
GSM1588965
ID:
301588965

SRA Run Selector

8.

Oct4-0hr_ChIPSeq

Organism:
Mus musculus
Source name:
embryonic stem cells
Platform:
GPL9250
Series:
GSE65192
Download data: TDF
Sample
Accession:
GSM1588964
ID:
301588964

SRA Run Selector

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db=gds|term=GSE65192[Accession]|query=1|qty=2|blobid=MCID_687c19958e0910894b1b7be2|ismultiple=true|min_list=5|max_list=20|def_tree=20|def_list=|def_view=|url=/Taxonomy/backend/subset.cgi?|trace_url=/stat?
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