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Items: 11

1.

PFKFB3 drives renal fibrosis through promoting histone lactylation-mediated NF- B activation [RNA-seq]

(Submitter supplied) Persistently elevated glycolysis in kidney has been demonstrated to promote chronic kidney disease. However, the underlying mechanism remains largely unclear. Here, we observed that PFKFB3, a key glycolytic enzyme, was remarkably induced in kidney proximal tubular cells following ischemia-reperfusion injury in mice, as well as in multiple etiologies of chronic kidney disease patients. Proximal tubular epithelial-specific deletion of PFKFB3 significantly reduced renal lactate levels, mitigated inflammation and fibrosis, and preserved renal function in the IRI mouse model. more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL24247
9 Samples
Download data: XLS
Series
Accession:
GSE266242
ID:
200266242

2.

Illumina NovaSeq 6000 (Mus musculus)

Organism:
Mus musculus
19670 Series
774308 Samples
Download data
Platform
Accession:
GPL24247
ID:
100024247

3.

Pfkfb3ΔPTC3, Kidney, IRI day14

Organism:
Mus musculus
Source name:
kidney
Platform:
GPL24247
Series:
GSE266242
Download data
Sample
Accession:
GSM8242999
ID:
308242999

SRA Run Selector

4.

Pfkfb3ΔPTC2, Kidney, IRI day14

Organism:
Mus musculus
Source name:
kidney
Platform:
GPL24247
Series:
GSE266242
Download data
Sample
Accession:
GSM8242998
ID:
308242998

SRA Run Selector

5.

Pfkfb3ΔPTC1, Kidney, IRI day14

Organism:
Mus musculus
Source name:
kidney
Platform:
GPL24247
Series:
GSE266242
Download data
Sample
Accession:
GSM8242997
ID:
308242997

SRA Run Selector

6.

Pfkfb3WT3, Kidney, IRI day14

Organism:
Mus musculus
Source name:
kidney
Platform:
GPL24247
Series:
GSE266242
Download data
Sample
Accession:
GSM8242996
ID:
308242996

SRA Run Selector

7.

Pfkfb3WT2, Kidney, IRI day14

Organism:
Mus musculus
Source name:
kidney
Platform:
GPL24247
Series:
GSE266242
Download data
Sample
Accession:
GSM8242995
ID:
308242995

SRA Run Selector

8.

Pfkfb3WT1, Kidney, IRI day14

Organism:
Mus musculus
Source name:
kidney
Platform:
GPL24247
Series:
GSE266242
Download data
Sample
Accession:
GSM8242994
ID:
308242994

SRA Run Selector

9.

Pfkfb3WT3, Kidney, Sham

Organism:
Mus musculus
Source name:
kidney
Platform:
GPL24247
Series:
GSE266242
Download data
Sample
Accession:
GSM8242993
ID:
308242993

SRA Run Selector

10.

Pfkfb3WT2, Kidney, Sham

Organism:
Mus musculus
Source name:
kidney
Platform:
GPL24247
Series:
GSE266242
Download data
Sample
Accession:
GSM8242992
ID:
308242992

SRA Run Selector

11.

Pfkfb3WT1, Kidney, Sham

Organism:
Mus musculus
Source name:
kidney
Platform:
GPL24247
Series:
GSE266242
Download data
Sample
Accession:
GSM8242991
ID:
308242991

SRA Run Selector

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