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1.

Effect of deletion of SPTLC1 on gene expression and differentiation of mouse Th17 cells in vitro

(Submitter supplied) Th17 cells are implicated in autoimmune diseases and several metabolic processes are shown to be important for their development and function. However, the role of de novo sphingolipid biosynthesis in their differentiation and function is less known. To investigate the role of SPTLC1(major subunit of serine palmitoyl transferase enzyme (SPT) that catalyzes the first and rate limiting step of de novo sphingolipid synthesis) in mouse Th17 cell differentiation, we have activated the WT and SPTLC1 defecient (KO) naïve CD4+ T cells, isolated from mouse spleen and lymph nodes, in Th17 differentiating condition in the precence and absence of NAC ( N-acetyl cysteine) and 3-KDS (3-ketodihydrosphingosine).
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL24247
24 Samples
Download data: XLS
Series
Accession:
GSE254602
ID:
200254602

PubMed Full text in PMC Similar studies

2.

Illumina NovaSeq 6000 (Mus musculus)

Organism:
Mus musculus
18027 Series
747942 Samples
Download data
Platform
Accession:
GPL24247
ID:
100024247

3.

KO naïve CD4+ T cells biol rep 3

Organism:
Mus musculus
Source name:
CD4+T cells
Platform:
GPL24247
Series:
GSE254602
Download data
Sample
Accession:
GSM8046931
ID:
308046931

SRA Run Selector

4.

KO naïve CD4+ T cells biol rep 2

Organism:
Mus musculus
Source name:
CD4+T cells
Platform:
GPL24247
Series:
GSE254602
Download data
Sample
Accession:
GSM8046930
ID:
308046930

SRA Run Selector

5.

KO naïve CD4+ T cells biol rep 1

Organism:
Mus musculus
Source name:
CD4+T cells
Platform:
GPL24247
Series:
GSE254602
Download data
Sample
Accession:
GSM8046929
ID:
308046929

SRA Run Selector

6.

WT naïve CD4+ T cells biol rep 3

Organism:
Mus musculus
Source name:
CD4+T cells
Platform:
GPL24247
Series:
GSE254602
Download data
Sample
Accession:
GSM8046928
ID:
308046928

SRA Run Selector

7.

WT naïve CD4+ T cells biol rep 2

Organism:
Mus musculus
Source name:
CD4+T cells
Platform:
GPL24247
Series:
GSE254602
Download data
Sample
Accession:
GSM8046927
ID:
308046927

SRA Run Selector

8.

WT naïve CD4+ T cells biol rep 1

Organism:
Mus musculus
Source name:
CD4+T cells
Platform:
GPL24247
Series:
GSE254602
Download data
Sample
Accession:
GSM8046926
ID:
308046926

SRA Run Selector

9.

KO Th17 with NAC biol rep 3

Organism:
Mus musculus
Source name:
CD4+T cells
Platform:
GPL24247
Series:
GSE254602
Download data
Sample
Accession:
GSM8046925
ID:
308046925

SRA Run Selector

10.

KO Th17 with NAC biol rep 2

Organism:
Mus musculus
Source name:
CD4+T cells
Platform:
GPL24247
Series:
GSE254602
Download data
Sample
Accession:
GSM8046924
ID:
308046924

SRA Run Selector

11.

KO Th17 with NAC biol rep 1

Organism:
Mus musculus
Source name:
CD4+T cells
Platform:
GPL24247
Series:
GSE254602
Download data
Sample
Accession:
GSM8046923
ID:
308046923

SRA Run Selector

12.

WT Th17 with NAC biol rep 3

Organism:
Mus musculus
Source name:
CD4+T cells
Platform:
GPL24247
Series:
GSE254602
Download data
Sample
Accession:
GSM8046922
ID:
308046922

SRA Run Selector

13.

WT Th17 with NAC biol rep 2

Organism:
Mus musculus
Source name:
CD4+T cells
Platform:
GPL24247
Series:
GSE254602
Download data
Sample
Accession:
GSM8046921
ID:
308046921

SRA Run Selector

14.

WT Th17 with NAC biol rep 1

Organism:
Mus musculus
Source name:
CD4+T cells
Platform:
GPL24247
Series:
GSE254602
Download data
Sample
Accession:
GSM8046920
ID:
308046920

SRA Run Selector

15.

KO Th17 with 3-KDS biol rep 3

Organism:
Mus musculus
Source name:
CD4+T cells
Platform:
GPL24247
Series:
GSE254602
Download data
Sample
Accession:
GSM8046919
ID:
308046919

SRA Run Selector

16.

KO Th17 with 3-KDS biol rep 2

Organism:
Mus musculus
Source name:
CD4+T cells
Platform:
GPL24247
Series:
GSE254602
Download data
Sample
Accession:
GSM8046918
ID:
308046918

SRA Run Selector

17.

KO Th17 with 3-KDS biol rep 1

Organism:
Mus musculus
Source name:
CD4+T cells
Platform:
GPL24247
Series:
GSE254602
Download data
Sample
Accession:
GSM8046917
ID:
308046917

SRA Run Selector

18.

WT Th17 with 3-KDS biol rep 3

Organism:
Mus musculus
Source name:
CD4+T cells
Platform:
GPL24247
Series:
GSE254602
Download data
Sample
Accession:
GSM8046916
ID:
308046916

SRA Run Selector

19.

WT Th17 with 3-KDS biol rep 2

Organism:
Mus musculus
Source name:
CD4+T cells
Platform:
GPL24247
Series:
GSE254602
Download data
Sample
Accession:
GSM8046915
ID:
308046915

SRA Run Selector

20.

WT Th17 with 3-KDS biol rep 1

Organism:
Mus musculus
Source name:
CD4+T cells
Platform:
GPL24247
Series:
GSE254602
Download data
Sample
Accession:
GSM8046914
ID:
308046914

SRA Run Selector

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