GSE253045[Accession] - GEO DataSets - NCBI

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Items: 20

Select item 2002530451.

IMPDH2 filaments protect from neurodegeneration in AMPD2 deficiency

(Submitter supplied) Metabolic dysregulation is one of the most common causes of pediatric neurodegenerative disorders. However, how the disruption of ubiquitous and essential metabolic pathways predominantly affect neural tissue remains unclear. Here we use a mouse model of AMPD2 deficiency to study cellular and molecular mechanisms that lead to selective neuronal vulnerability to purine metabolism imbalance. We show that AMPD deficiency in mice primarily leads to hippocampal dentate gyrus degeneration despite causing a generalized reduction of brain GTP levels. more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL24247
18 Samples

Download data: BW

Series

Accession:: GSE253045

ID:: 200253045

PubMed Full text in PMC Similar studies

Select item 1000242472.

Illumina NovaSeq 6000 (Mus musculus)

Organism:: Mus musculus

17962 Series
746799 Samples

Platform

Accession:: GPL24247

ID:: 100024247

Select item 3080129023.

hippocampus, dKO, biol rep 3

Organism:: Mus musculus

Source name:: hippocampus

Platform:: GPL24247
Series:: GSE253045

Download data: BW

Sample

Accession:: GSM8012902

ID:: 308012902

SRA Run Selector

Select item 3080129014.

hippocampus, dKO, biol rep 2

Organism:: Mus musculus

Source name:: hippocampus

Platform:: GPL24247
Series:: GSE253045

Download data: BW

Sample

Accession:: GSM8012901

ID:: 308012901

SRA Run Selector

Select item 3080129005.

hippocampus, dKO, biol rep 1

Organism:: Mus musculus

Source name:: hippocampus

Platform:: GPL24247
Series:: GSE253045

Download data: BW

Sample

Accession:: GSM8012900

ID:: 308012900

SRA Run Selector

Select item 3080128996.

hippocampus, Ctrl, biol rep 3

Organism:: Mus musculus

Source name:: hippocampus

Platform:: GPL24247
Series:: GSE253045

Download data: BW

Sample

Accession:: GSM8012899

ID:: 308012899

SRA Run Selector

Select item 3080128987.

hippocampus, Ctrl, biol rep 2

Organism:: Mus musculus

Source name:: hippocampus

Platform:: GPL24247
Series:: GSE253045

Download data: BW

Sample

Accession:: GSM8012898

ID:: 308012898

SRA Run Selector

Select item 3080128978.

hippocampus, Ctrl, biol rep 1

Organism:: Mus musculus

Source name:: hippocampus

Platform:: GPL24247
Series:: GSE253045

Download data: BW

Sample

Accession:: GSM8012897

ID:: 308012897

SRA Run Selector

Select item 3080128969.

cortex, dKO, biol rep 3

Organism:: Mus musculus

Source name:: cortex

Platform:: GPL24247
Series:: GSE253045

Download data: BW

Sample

Accession:: GSM8012896

ID:: 308012896

SRA Run Selector

Select item 30801289510.

cortex, dKO, biol rep 2

Organism:: Mus musculus

Source name:: cortex

Platform:: GPL24247
Series:: GSE253045

Download data: BW

Sample

Accession:: GSM8012895

ID:: 308012895

SRA Run Selector

Select item 30801289411.

cortex, dKO, biol rep 1

Organism:: Mus musculus

Source name:: cortex

Platform:: GPL24247
Series:: GSE253045

Download data: BW

Sample

Accession:: GSM8012894

ID:: 308012894

SRA Run Selector

Select item 30801289312.

cortex, Ctrl, biol rep 3

Organism:: Mus musculus

Source name:: cortex

Platform:: GPL24247
Series:: GSE253045

Download data: BW

Sample

Accession:: GSM8012893

ID:: 308012893

SRA Run Selector

Select item 30801289213.

cortex, Ctrl, biol rep 2

Organism:: Mus musculus

Source name:: cortex

Platform:: GPL24247
Series:: GSE253045

Download data: BW

Sample

Accession:: GSM8012892

ID:: 308012892

SRA Run Selector

Select item 30801289114.

cortex, Ctrl, biol rep 1

Organism:: Mus musculus

Source name:: cortex

Platform:: GPL24247
Series:: GSE253045

Download data: BW

Sample

Accession:: GSM8012891

ID:: 308012891

SRA Run Selector

Select item 30801289015.

cerebellum, dKO, biol rep 3

Organism:: Mus musculus

Source name:: cerebellum

Platform:: GPL24247
Series:: GSE253045

Download data: BW

Sample

Accession:: GSM8012890

ID:: 308012890

SRA Run Selector

Select item 30801288916.

cerebellum, dKO, biol rep 2

Organism:: Mus musculus

Source name:: cerebellum

Platform:: GPL24247
Series:: GSE253045

Download data: BW

Sample

Accession:: GSM8012889

ID:: 308012889

SRA Run Selector

Select item 30801288817.

cerebellum, dKO, biol rep 1

Organism:: Mus musculus

Source name:: cerebellum

Platform:: GPL24247
Series:: GSE253045

Download data: BW

Sample

Accession:: GSM8012888

ID:: 308012888

SRA Run Selector

Select item 30801288718.

cerebellum, Ctrl, biol rep 3

Organism:: Mus musculus

Source name:: cerebellum

Platform:: GPL24247
Series:: GSE253045

Download data: BW

Sample

Accession:: GSM8012887

ID:: 308012887

SRA Run Selector

Select item 30801288619.

cerebellum, Ctrl, biol rep 2

Organism:: Mus musculus

Source name:: cerebellum

Platform:: GPL24247
Series:: GSE253045

Download data: BW

Sample

Accession:: GSM8012886

ID:: 308012886

SRA Run Selector

Select item 30801288520.

cerebellum, Ctrl, biol rep 1

Organism:: Mus musculus

Source name:: cerebellum

Platform:: GPL24247
Series:: GSE253045

Download data: BW

Sample

Accession:: GSM8012885

ID:: 308012885

SRA Run Selector

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