GSE248202[Accession] - GEO DataSets - NCBI

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Select item 2002482021.

Lineage-specific intolerance to oncogenic drivers restricts histological transformation [scRNA-Seq]

(Submitter supplied) Lung adenocarcinoma (LUAD) and small cell lung cancer (SCLC) are thought to originate from different epithelial cell types in the lung. Intriguingly, LUAD can histologically transform into SCLC following treatment with targeted therapies. Here we designed models to follow the conversion of LUAD to SCLC and found the barrier to histological transformation converges on tolerance to Myc, which we implicate as a lineage-specific driver of the pulmonary neuroendocrine cell. more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL24247
27 Samples

Download data: H5AD

Series

Accession:: GSE248202

ID:: 200248202

PubMed Full text in PMC Similar studies

Select item 1000242472.

Illumina NovaSeq 6000 (Mus musculus)

Organism:: Mus musculus

17141 Series
735826 Samples

Platform

Accession:: GPL24247

ID:: 100024247

Select item 3079083423.

Lung, AT2, EGFR, Tp53 and Pten loss, Myc transgene, pooled

Organism:: Mus musculus

Source name:: Lung

Platform:: GPL24247
Series:: GSE248202 GSE248207

Sample

Accession:: GSM7908342

ID:: 307908342

SRA Run Selector

Select item 3079083414.

Lung, AT2, EGFR, Tp53 and Pten loss, pooled

Organism:: Mus musculus

Source name:: Lung

Platform:: GPL24247
Series:: GSE248202 GSE248207

Sample

Accession:: GSM7908341

ID:: 307908341

SRA Run Selector

Select item 3079083405.

Lung, Normal AT2, Pten loss, Myc transgene, pooled

Organism:: Mus musculus

Source name:: Lung

Platform:: GPL24247
Series:: GSE248202 GSE248207

Sample

Accession:: GSM7908340

ID:: 307908340

SRA Run Selector

Select item 3079083396.

Lung, Normal PNEC, Myc transgene, pooled

Organism:: Mus musculus

Source name:: Lung

Platform:: GPL24247
Series:: GSE248202 GSE248207

Sample

Accession:: GSM7908339

ID:: 307908339

SRA Run Selector

Select item 3079083387.

Lung, Normal AT2, Myc transgene, pooled

Organism:: Mus musculus

Source name:: Lung

Platform:: GPL24247
Series:: GSE248202 GSE248207

Sample

Accession:: GSM7908338

ID:: 307908338

SRA Run Selector

Select item 3079083378.

Lung, Normal AT2, Pten loss, pooled

Organism:: Mus musculus

Source name:: Lung

Platform:: GPL24247
Series:: GSE248202 GSE248207

Sample

Accession:: GSM7908337

ID:: 307908337

SRA Run Selector

Select item 3079083369.

Lung, Normal PNEC, pooled

Organism:: Mus musculus

Source name:: Lung

Platform:: GPL24247
Series:: GSE248202 GSE248207

Sample

Accession:: GSM7908336

ID:: 307908336

SRA Run Selector

Select item 30790833510.

Lung, Normal AT2, pooled

Organism:: Mus musculus

Source name:: Lung

Platform:: GPL24247
Series:: GSE248202 GSE248207

Sample

Accession:: GSM7908335

ID:: 307908335

SRA Run Selector

Select item 30790833411.

Lung, de novo LUAD, Myc wt, pooled

Organism:: Mus musculus

Source name:: Lung

Platform:: GPL24247
Series:: GSE248202 GSE248207

Sample

Accession:: GSM7908334

ID:: 307908334

SRA Run Selector

Select item 30790833312.

Lung, de novo LUAD, Rb1 wt, off DOX, pooled

Organism:: Mus musculus

Source name:: Lung

Platform:: GPL24247
Series:: GSE248202 GSE248207

Sample

Accession:: GSM7908333

ID:: 307908333

SRA Run Selector

Select item 30790833213.

Lung, de novo LUAD, Rb1 wt, pooled

Organism:: Mus musculus

Source name:: Lung

Platform:: GPL24247
Series:: GSE248202 GSE248207

Sample

Accession:: GSM7908332

ID:: 307908332

SRA Run Selector

Select item 30790833114.

Lung, LUAD off DOX, time 3, pooled

Organism:: Mus musculus

Source name:: Lung

Platform:: GPL24247
Series:: GSE248202 GSE248207

Sample

Accession:: GSM7908331

ID:: 307908331

SRA Run Selector

Select item 30790833015.

Lung, LUAD restarted on DOX, pooled

Organism:: Mus musculus

Source name:: Lung

Platform:: GPL24247
Series:: GSE248202 GSE248207

Sample

Accession:: GSM7908330

ID:: 307908330

SRA Run Selector

Select item 30790832916.

Lung, LUAD off DOX, time 2, pooled

Organism:: Mus musculus

Source name:: Lung

Platform:: GPL24247
Series:: GSE248202 GSE248207

Sample

Accession:: GSM7908329

ID:: 307908329

SRA Run Selector

Select item 30790832817.

Lung, SCLC genotype, Pten loss, AT2 origin, time 2, pooled

Organism:: Mus musculus

Source name:: Lung

Platform:: GPL24247
Series:: GSE248202 GSE248207

Sample

Accession:: GSM7908328

ID:: 307908328

SRA Run Selector

Select item 30790832718.

Lung, SCLC genotype, Pten loss, AT2 origin, time 1, pooled

Organism:: Mus musculus

Source name:: Lung

Platform:: GPL24247
Series:: GSE248202 GSE248207

Sample

Accession:: GSM7908327

ID:: 307908327

SRA Run Selector

Select item 30790832619.

Lung, SCLC genotype, AT2 origin, pooled

Organism:: Mus musculus

Source name:: Lung

Platform:: GPL24247
Series:: GSE248202 GSE248207

Sample

Accession:: GSM7908326

ID:: 307908326

SRA Run Selector

Select item 30790832520.

Lung, LUAD off DOX, time 1, pooled

Organism:: Mus musculus

Source name:: Lung

Platform:: GPL24247
Series:: GSE248202 GSE248207

Sample

Accession:: GSM7908325

ID:: 307908325

SRA Run Selector

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