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Items: 20

1.

Neuronal DNA double-strand breaks lead to genome structural variations and 3D genome disruption in neurodegeneration [Hi-C]

(Submitter supplied) Persistent DNA double-strand breaks (DSBs) in neurons are an early pathological hallmark of neurodegenerative diseases including Alzheimer’s Disease (AD), with the potential to disrupt genome integrity. We used single-nucleus RNA-seq in human post-mortem prefrontal cortex samples and found that excitatory neurons in AD were enriched for somatic mosaic gene fusions. Gene fusions were particularly enriched in excitatory neurons with DNA damage repair and senescence gene signatures. more...
Organism:
Mus musculus
Type:
Other
Platform:
GPL19057
18 Samples
Download data: HIC
Series
Accession:
GSE227443
ID:
200227443

PubMed Full text in PMC Similar studies

2.

Illumina NextSeq 500 (Mus musculus)

Organism:
Mus musculus
10920 Series
308088 Samples
Download data
Platform
Accession:
GPL19057
ID:
100019057

3.

Hi-C_TauWT_3months

Organism:
Mus musculus
Source name:
Forebrain
Platform:
GPL19057
Series:
GSE227443 GSE227445
Download data: HIC
Sample
Accession:
GSM7100693
ID:
307100693

SRA Run Selector

4.

Hi-C_TauWT_11months

Organism:
Mus musculus
Source name:
Forebrain
Platform:
GPL19057
Series:
GSE227443 GSE227445
Download data: HIC
Sample
Accession:
GSM7100691
ID:
307100691

SRA Run Selector

5.

Hi-C_TauP301S_3months

Organism:
Mus musculus
Source name:
Forebrain
Platform:
GPL19057
Series:
GSE227443 GSE227445
Download data: HIC
Sample
Accession:
GSM7100690
ID:
307100690

SRA Run Selector

6.

Hi-C_TauP301S_11months

Organism:
Mus musculus
Source name:
Forebrain
Platform:
GPL19057
Series:
GSE227443 GSE227445
Download data: HIC
Sample
Accession:
GSM7100688
ID:
307100688

SRA Run Selector

7.

Hi-C_ETP_1uM48h_Replicate2

Organism:
Mus musculus
Source name:
Primary culture
Platform:
GPL19057
Series:
GSE227443 GSE227445
Download data: HIC
Sample
Accession:
GSM7100687
ID:
307100687

SRA Run Selector

8.

Hi-C_ETP_1uM48h_Replicate1

Organism:
Mus musculus
Source name:
Primary culture
Platform:
GPL19057
Series:
GSE227443 GSE227445
Download data: HIC
Sample
Accession:
GSM7100685
ID:
307100685

SRA Run Selector

9.

Hi-C_ETPDMSOCon48h

Organism:
Mus musculus
Source name:
Primary culture
Platform:
GPL19057
Series:
GSE227443 GSE227445
Download data: HIC
Sample
Accession:
GSM7100683
ID:
307100683

SRA Run Selector

10.

Hi-C_ETP_5uM48h_91374012

Organism:
Mus musculus
Source name:
Primary culture
Platform:
GPL19057
Series:
GSE227443 GSE227445
Download data: HIC
Sample
Accession:
GSM7100682
ID:
307100682

SRA Run Selector

11.

Hi-C_DMSOCon_91374012

Organism:
Mus musculus
Source name:
Primary culture
Platform:
GPL19057
Series:
GSE227443 GSE227445
Download data: HIC
Sample
Accession:
GSM7100680
ID:
307100680

SRA Run Selector

12.

Hi-C_CK-p25_Step2Replicate3

Organism:
Mus musculus
Source name:
Forebrain
Platform:
GPL19057
Series:
GSE227443 GSE227445
Download data
Sample
Accession:
GSM7100679
ID:
307100679

SRA Run Selector

13.

Hi-C_CK-p25_Step2Replicate2

Organism:
Mus musculus
Source name:
Forebrain
Platform:
GPL19057
Series:
GSE227443 GSE227445
Download data
Sample
Accession:
GSM7100678
ID:
307100678

SRA Run Selector

14.

Hi-C_CK-p25_Step2Replicate1

Organism:
Mus musculus
Source name:
Forebrain
Platform:
GPL19057
Series:
GSE227443 GSE227445
Download data
Sample
Accession:
GSM7100677
ID:
307100677

SRA Run Selector

15.

Hi-C_CK-p25_Step1Replicate3

Organism:
Mus musculus
Source name:
Forebrain
Platform:
GPL19057
Series:
GSE227443 GSE227445
Download data
Sample
Accession:
GSM7100676
ID:
307100676

SRA Run Selector

16.

Hi-C_CK-p25_Step1Replicate2

Organism:
Mus musculus
Source name:
Forebrain
Platform:
GPL19057
Series:
GSE227443 GSE227445
Download data
Sample
Accession:
GSM7100674
ID:
307100674

SRA Run Selector

17.

Hi-C_CK-p25_Step1Repicate1

Organism:
Mus musculus
Source name:
Forebrain
Platform:
GPL19057
Series:
GSE227443 GSE227445
Download data
Sample
Accession:
GSM7100673
ID:
307100673

SRA Run Selector

18.

Hi-C_CK-p25_ConReplicate3

Organism:
Mus musculus
Source name:
Forebrain
Platform:
GPL19057
Series:
GSE227443 GSE227445
Download data
Sample
Accession:
GSM7100671
ID:
307100671

SRA Run Selector

19.

Hi-C_CK-p25_ConReplicate2

Organism:
Mus musculus
Source name:
Forebrain
Platform:
GPL19057
Series:
GSE227443 GSE227445
Download data
Sample
Accession:
GSM7100669
ID:
307100669

SRA Run Selector

20.

Hi-C_CK-p25_ConReplicate1

Organism:
Mus musculus
Source name:
Forebrain
Platform:
GPL19057
Series:
GSE227443 GSE227445
Download data
Sample
Accession:
GSM7100667
ID:
307100667

SRA Run Selector

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