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Items: 11

1.

A novel oral arginase 1/2 inhibitor enhances the antitumor effect of PD-1 inhibition in murine experimental gliomas by altering the immunosuppressive environment.

(Submitter supplied) Malignant gliomas are common and aggressive primary brain tumors which are incurable by conventional therapies. Immunotherapy with the immune checkpoint inhibitors is not effective due to the highly immunosuppressive tumor microenvironment (TME). Clinical and experimental data show upregulation of Arginase1 (ARG1) expression in rodent and human malignant gliomas. The elevated ARG1 activity leads to depletion of L-arginine required for proliferation of T lymphocytes and natural killer cells. more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL18480
9 Samples
Download data: TAB
Series
Accession:
GSE173865
ID:
200173865

PubMed Full text in PMC Similar studies SRA Run Selector

2.

Illumina HiSeq 1500 (Mus musculus)

Organism:
Mus musculus
617 Series
11546 Samples
Download data
Platform
Accession:
GPL18480
ID:
100018480

3.

CHECK rep2

Organism:
Mus musculus
Source name:
CD11b+ FACS sorted
Platform:
GPL18480
Series:
GSE173865
Download data
Sample
Accession:
GSM5282108
ID:
305282108

SRA Run Selector

4.

CHECK rep1

Organism:
Mus musculus
Source name:
CD11b+ FACS sorted
Platform:
GPL18480
Series:
GSE173865
Download data
Sample
Accession:
GSM5282107
ID:
305282107

SRA Run Selector

5.

COM rep3

Organism:
Mus musculus
Source name:
CD11b+ FACS sorted
Platform:
GPL18480
Series:
GSE173865
Download data
Sample
Accession:
GSM5282106
ID:
305282106

SRA Run Selector

6.

COM rep2

Organism:
Mus musculus
Source name:
CD11b+ FACS sorted
Platform:
GPL18480
Series:
GSE173865
Download data
Sample
Accession:
GSM5282105
ID:
305282105

SRA Run Selector

7.

COM rep1

Organism:
Mus musculus
Source name:
CD11b+ FACS sorted
Platform:
GPL18480
Series:
GSE173865
Download data
Sample
Accession:
GSM5282104
ID:
305282104

SRA Run Selector

8.

OAT rep2

Organism:
Mus musculus
Source name:
CD11b+ FACS sorted
Platform:
GPL18480
Series:
GSE173865
Download data
Sample
Accession:
GSM5282103
ID:
305282103

SRA Run Selector

9.

OAT rep1

Organism:
Mus musculus
Source name:
CD11b+ FACS sorted
Platform:
GPL18480
Series:
GSE173865
Download data
Sample
Accession:
GSM5282102
ID:
305282102

SRA Run Selector

10.

CTR rep2

Organism:
Mus musculus
Source name:
CD11b+ FACS sorted
Platform:
GPL18480
Series:
GSE173865
Download data
Sample
Accession:
GSM5282101
ID:
305282101

SRA Run Selector

11.

CTR rep1

Organism:
Mus musculus
Source name:
CD11b+ FACS sorted
Platform:
GPL18480
Series:
GSE173865
Download data
Sample
Accession:
GSM5282100
ID:
305282100

SRA Run Selector

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db=gds|term=GSE173865[Accession]|query=1|qty=2|blobid=MCID_67de672873a8307cd80e91c8|ismultiple=true|min_list=5|max_list=20|def_tree=20|def_list=|def_view=|url=/Taxonomy/backend/subset.cgi?|trace_url=/stat?
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