GSE173584[Accession] - GEO DataSets - NCBI

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HIC2 represses BCL11A transcription to regulate hemoglobin switching during development (ChIP-Seq)

(Submitter supplied) The switch from fetal to adult hemoglobin production has been studied in great depth in part because of its relevance to the treatment of hemolobinopathies. Transcription factor BCL11A, which is essential for repression of the fetal beta-type globin (γ-globin) genes after birth, is largely controlled at the level of transcription but the mechanism of BCL11A developmental control is unknown. Here, using a CRISPR-Cas9 screen in human erythroblasts, we identify transcription factor HIC2 as a repressor of BCL11A transcription. more...

Organism:: Mus musculus; Homo sapiens

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platforms:: GPL30172 GPL30173
27 Samples

Download data: BED, BIGWIG

Series

Accession:: GSE173584

ID:: 200173584

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 1000301732.

NextSeq 2000 (Homo sapiens)

Organism:: Homo sapiens

1573 Series
33364 Samples

Platform

Accession:: GPL30173

ID:: 100030173

Select item 1000301723.

NextSeq 2000 (Mus musculus)

Organism:: Mus musculus

1345 Series
22642 Samples

Platform

Accession:: GPL30172

ID:: 100030172

Select item 3058000464.

ChIP-Seq Newborn erythroblasts HIC2

Organism:: Homo sapiens

Source name:: Cord blood erythroblasts

Platform:: GPL30173
Series:: GSE173584 GSE173587

Download data: BED, BIGWIG

Sample

Accession:: GSM5800046

ID:: 305800046

SRA Run Selector

Select item 3052712235.

ChIP-Seq HUDEP1 cells HIC2 KO GATA1 ChIP-seq rep2

Organism:: Homo sapiens

Source name:: HUDEP1 cells

Platform:: GPL30173
Series:: GSE173584 GSE173587

Download data: BED, BIGWIG

Sample

Accession:: GSM5271223

ID:: 305271223

SRA Run Selector

Select item 3052712226.

ChIP-Seq HUDEP1 cells HIC2 KO GATA1 ChIP-seq rep1

Organism:: Homo sapiens

Source name:: HUDEP1 cells

Platform:: GPL30173
Series:: GSE173584 GSE173587

Download data: BED, BIGWIG

Sample

Accession:: GSM5271222

ID:: 305271222

SRA Run Selector

Select item 3052712217.

ChIP-Seq HUDEP1 cells HIC2 KO input

Organism:: Homo sapiens

Source name:: HUDEP1 cells

Platform:: GPL30173
Series:: GSE173584 GSE173587

Sample

Accession:: GSM5271221

ID:: 305271221

SRA Run Selector

Select item 3052712208.

ChIP-Seq HUDEP1 cells WT GATA1 ChIP-seq rep2

Organism:: Homo sapiens

Source name:: HUDEP1 cells

Platform:: GPL30173
Series:: GSE173584 GSE173587

Download data: BED, BIGWIG

Sample

Accession:: GSM5271220

ID:: 305271220

SRA Run Selector

Select item 3052712199.

ChIP-Seq HUDEP1 cells WT GATA1 ChIP-seq rep1

Organism:: Homo sapiens

Source name:: HUDEP1 cells

Platform:: GPL30173
Series:: GSE173584 GSE173587

Download data: BED, BIGWIG

Sample

Accession:: GSM5271219

ID:: 305271219

SRA Run Selector

Select item 30527121810.

ChIP-Seq HUDEP1 cells WT input

Organism:: Homo sapiens

Source name:: HUDEP1 cells

Platform:: GPL30173
Series:: GSE173584 GSE173587

Sample

Accession:: GSM5271218

ID:: 305271218

SRA Run Selector

Select item 30527121711.

ChIP-Seq HUDEP2 cells HIC2-ER induced HA ChIP-seq rep2

Organism:: Homo sapiens

Source name:: HUDEP2 cells

Platform:: GPL30173
Series:: GSE173584 GSE173587

Download data: BED, BIGWIG

Sample

Accession:: GSM5271217

ID:: 305271217

SRA Run Selector

Select item 30527121612.

ChIP-Seq HUDEP2 cells HIC2-ER induced HA ChIP-seq rep1

Organism:: Homo sapiens

Source name:: HUDEP2 cells

Platform:: GPL30173
Series:: GSE173584 GSE173587

Download data: BED, BIGWIG

Sample

Accession:: GSM5271216

ID:: 305271216

SRA Run Selector

Select item 30527121513.

ChIP-Seq HUDEP2 cells HIC2-ER induced input

Organism:: Homo sapiens

Source name:: HUDEP2 cells

Platform:: GPL30173
Series:: GSE173584 GSE173587

Sample

Accession:: GSM5271215

ID:: 305271215

SRA Run Selector

Select item 30527121414.

ChIP-Seq HUDEP2 cells HIC2-ER uninduced HA ChIP-seq rep2

Organism:: Homo sapiens

Source name:: HUDEP2 cells

Platform:: GPL30173
Series:: GSE173584 GSE173587

Download data: BED, BIGWIG

Sample

Accession:: GSM5271214

ID:: 305271214

SRA Run Selector

Select item 30527121315.

ChIP-Seq HUDEP2 cells HIC2-ER uninduced HA ChIP-seq rep1

Organism:: Homo sapiens

Source name:: HUDEP2 cells

Platform:: GPL30173
Series:: GSE173584 GSE173587

Download data: BED, BIGWIG

Sample

Accession:: GSM5271213

ID:: 305271213

SRA Run Selector

Select item 30527121216.

ChIP-Seq HUDEP2 cells HIC2-ER uninduced input

Organism:: Homo sapiens

Source name:: HUDEP2 cells

Platform:: GPL30173
Series:: GSE173584 GSE173587

Sample

Accession:: GSM5271212

ID:: 305271212

SRA Run Selector

Select item 30527121117.

ChIP-Seq HUDEP2 cells HIC2-OE H3K27ac ChIP-seq

Organism:: Homo sapiens

Source name:: HUDEP2 cells

Platform:: GPL30173
Series:: GSE173584 GSE173587

Download data: BED, BIGWIG

Sample

Accession:: GSM5271211

ID:: 305271211

SRA Run Selector

Select item 30527121018.

ChIP-Seq HUDEP2 cells HIC2-OE GATA1 ChIP-seq rep2

Organism:: Homo sapiens

Source name:: HUDEP2 cells

Platform:: GPL30173
Series:: GSE173584 GSE173587

Download data: BED, BIGWIG

Sample

Accession:: GSM5271210

ID:: 305271210

SRA Run Selector

Select item 30527120919.

ChIP-Seq HUDEP2 cells HIC2-OE GATA1 ChIP-seq rep1

Organism:: Homo sapiens

Source name:: HUDEP2 cells

Platform:: GPL30173
Series:: GSE173584 GSE173587

Download data: BED, BIGWIG

Sample

Accession:: GSM5271209

ID:: 305271209

SRA Run Selector

Select item 30527120820.

ChIP-Seq HUDEP2 cells HIC2-OE input

Organism:: Homo sapiens

Source name:: HUDEP2 cells

Platform:: GPL30173
Series:: GSE173584 GSE173587

Sample

Accession:: GSM5271208

ID:: 305271208

SRA Run Selector

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