GEO DataSets

(Submitter supplied) DJ-1 is an atypical peroxiredoxin-like peroxidase that may act as a redox-dependent chaperone and a regulator of transcription. To explore DJ-1-mediated transcriptional control in Parkinson’s disease (PD), we generated human neuroblastoma cells with inducible knock-down of DJ-1 expression. We then used functional genomic techniques to identify novel pathways dysregulated by loss of DJ-1 function. Using microarray gene expression profiling, we found that DJ-1 silencing alters the expression of 26 genes, with 10 down-regulated and 16 up-regulated transcripts. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS3750

Platform:

GPL571

8 Samples

Download data: CEL

Analysis of SH-SY5Y neuroblastoma cells depleted of DJ-1, an atypical peroxiredoxin-like peroxidase. Mutations in the gene encoding DJ-1 cause autosomal recessive early-onset Parkinson disease (AREP). Results provide insight into the molecular mechanisms underlying DJ-1-mediated PD pathogenesis.

Organism:

Homo sapiens

Type:

Expression profiling by array, transformed count, 2 genotype/variation sets

Platform:

GPL571

Series:

GSE17204

8 Samples

Download data: CEL

(Submitter supplied) Affymetrix submissions are typically submitted to GEO using the GEOarchive method described at http://www.ncbi.nlm.nih.gov/projects/geo/info/geo_affy.html June 03, 2009: annotation table updated with netaffx build 28 June 08, 2012: annotation table updated with netaffx build 32 July 01, 2016: annotation table updated with netaffx build 35 Protocol: see manufacturer's web site The GeneChip Human Genome U133A 2.0 Array is a single array representing 14,500 well-characterized human genes that can be used to explore human biology and disease processes. more...

Organism:

Homo sapiens

84 DataSets

641 Series

12 Related Platforms

24467 Samples

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