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Items: 1 to 20 of 26

1.

Chemotherapy-induced transposable elements activate MDA5 to enhance haematopoietic regeneration

(Submitter supplied) Haematopoietic stem cells (HSCs) are normally quiescent, but have evolved mechanisms to respond to stress. Here, we evaluate haematopoietic regeneration induced by chemotherapy. We detect robust chromatin reorganization followed by increased transcription of transposable elements (TEs) during early recovery. TE transcripts bind to and activate the innate immune receptor melanoma differentiation-associated protein 5 (MDA5) that generates an inflammatory response that is necessary for HSCs to exit quiescence. more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL21493
24 Samples
Download data: CSV, TXT
Series
Accession:
GSE129631
ID:
200129631

PubMed Full text in PMC Similar studies SRA Run Selector

2.

Illumina HiSeq 3000 (Mus musculus)

Organism:
Mus musculus
1185 Series
43085 Samples
Download data
Platform
Accession:
GPL21493
ID:
100021493

3.

IFIH1KO_P3_9

Organism:
Mus musculus
Source name:
library of 96 IFIH1-/- HSCs
Platform:
GPL21493
Series:
GSE129631
Download data: CSV
Sample
Accession:
GSM3717666
ID:
303717666

SRA Run Selector

4.

IFIH1KO_P3_12

Organism:
Mus musculus
Source name:
library of 96 IFIH1-/- HSCs
Platform:
GPL21493
Series:
GSE129631
Download data: CSV
Sample
Accession:
GSM3717665
ID:
303717665

SRA Run Selector

5.

IFIH1KO_P3_11

Organism:
Mus musculus
Source name:
library of 96 IFIH1-/- HSCs
Platform:
GPL21493
Series:
GSE129631
Download data: CSV
Sample
Accession:
GSM3717664
ID:
303717664

SRA Run Selector

6.

IFIH1KO_P3_10

Organism:
Mus musculus
Source name:
library of 96 IFIH1-/- HSCs
Platform:
GPL21493
Series:
GSE129631
Download data: CSV
Sample
Accession:
GSM3717663
ID:
303717663

SRA Run Selector

7.

IFIH1KO_P2_16

Organism:
Mus musculus
Source name:
library of 96 IFIH1-/- HSCs
Platform:
GPL21493
Series:
GSE129631
Download data: CSV
Sample
Accession:
GSM3717662
ID:
303717662

SRA Run Selector

8.

IFIH1KO_P2_15

Organism:
Mus musculus
Source name:
library of 96 IFIH1-/- HSCs
Platform:
GPL21493
Series:
GSE129631
Download data: CSV
Sample
Accession:
GSM3717661
ID:
303717661

SRA Run Selector

9.

IFIH1KO_P2_14

Organism:
Mus musculus
Source name:
library of 96 IFIH1-/- HSCs
Platform:
GPL21493
Series:
GSE129631
Download data: CSV
Sample
Accession:
GSM3717660
ID:
303717660

SRA Run Selector

10.

IFIH1KO_P2_13

Organism:
Mus musculus
Source name:
library of 96 IFIH1-/- HSCs
Platform:
GPL21493
Series:
GSE129631
Download data: CSV
Sample
Accession:
GSM3717659
ID:
303717659

SRA Run Selector

11.

IFIH1KO_P1_8

Organism:
Mus musculus
Source name:
library of 96 IFIH1-/- HSCs
Platform:
GPL21493
Series:
GSE129631
Download data: CSV
Sample
Accession:
GSM3717658
ID:
303717658

SRA Run Selector

12.

IFIH1KO_P1_7

Organism:
Mus musculus
Source name:
library of 96 IFIH1-/- HSCs
Platform:
GPL21493
Series:
GSE129631
Download data: CSV
Sample
Accession:
GSM3717657
ID:
303717657

SRA Run Selector

13.

IFIH1KO_P1_6

Organism:
Mus musculus
Source name:
library of 96 IFIH1-/- HSCs
Platform:
GPL21493
Series:
GSE129631
Download data: CSV
Sample
Accession:
GSM3717656
ID:
303717656

SRA Run Selector

14.

IFIH1KO_P1_5

Organism:
Mus musculus
Source name:
library of 96 IFIH1-/- HSCs
Platform:
GPL21493
Series:
GSE129631
Download data: CSV
Sample
Accession:
GSM3717655
ID:
303717655

SRA Run Selector

15.

IFIH1WT_P3_9

Organism:
Mus musculus
Source name:
library of 96 IFIH1+/+ HSCs
Platform:
GPL21493
Series:
GSE129631
Download data: CSV
Sample
Accession:
GSM3717654
ID:
303717654

SRA Run Selector

16.

IFIH1WT_P3_12

Organism:
Mus musculus
Source name:
library of 96 IFIH1+/+ HSCs
Platform:
GPL21493
Series:
GSE129631
Download data: CSV
Sample
Accession:
GSM3717653
ID:
303717653

SRA Run Selector

17.

IFIH1WT_P3_11

Organism:
Mus musculus
Source name:
library of 96 IFIH1+/+ HSCs
Platform:
GPL21493
Series:
GSE129631
Download data: CSV
Sample
Accession:
GSM3717652
ID:
303717652

SRA Run Selector

18.

IFIH1WT_P3_10

Organism:
Mus musculus
Source name:
library of 96 IFIH1+/+ HSCs
Platform:
GPL21493
Series:
GSE129631
Download data: CSV
Sample
Accession:
GSM3717651
ID:
303717651

SRA Run Selector

19.

IFIH1WT_P2_8

Organism:
Mus musculus
Source name:
library of 96 IFIH1+/+ HSCs
Platform:
GPL21493
Series:
GSE129631
Download data: CSV
Sample
Accession:
GSM3717650
ID:
303717650

SRA Run Selector

20.

IFIH1WT_P2_7

Organism:
Mus musculus
Source name:
library of 96 IFIH1+/+ HSCs
Platform:
GPL21493
Series:
GSE129631
Download data: CSV
Sample
Accession:
GSM3717649
ID:
303717649

SRA Run Selector

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