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Items: 1 to 20 of 190

1.

Chromatin mapping and single-cell immune profiling defines the temporal dynamics of ibrutinib drug response in chronic lymphocytic leukemia

(Submitter supplied) Chronic lymphocytic leukemia (CLL) is a genetically, epigenetically, and clinically heterogeneous disease. Despite this heterogeneity, the Bruton tyrosine kinase (BTK) inhibitor ibrutinib provides effective treatment for the vast majority of CLL patients. To define the underlining regulatory program, we analyzed high-resolution time courses of ibrutinib treatment in closely monitored patients, combining cellular phenotyping (flow cytometry), single-cell transcriptome profiling (scRNA-seq), and chromatin mapping (ATAC-seq). more...
Organism:
Homo sapiens
Type:
Genome binding/occupancy profiling by high throughput sequencing; Expression profiling by high throughput sequencing
Platform:
GPL20301
188 Samples
Download data: BIGWIG, NARROWPEAK
Series
Accession:
GSE111015
ID:
200111015
2.

Illumina HiSeq 4000 (Homo sapiens)

Platform
Accession:
GPL20301
ID:
100020301
3.

scRNA-seq on PBMCs from patient CLL8 after 30 days of ibrutinib treatment

Organism:
Homo sapiens
Source name:
PBMCs_CLL patient after 30 days of ibrutinib treatment
Platform:
GPL20301
Series:
GSE111014 GSE111015
Download data
Sample
Accession:
GSM3020404
ID:
303020404
4.

scRNA-seq on PBMCs from patient CLL8 after 120 days of ibrutinib treatment

Organism:
Homo sapiens
Source name:
PBMCs_CLL patient after 120 days of ibrutinib treatment
Platform:
GPL20301
Series:
GSE111014 GSE111015
Download data
Sample
Accession:
GSM3020403
ID:
303020403
5.

scRNA-seq on PBMCs from patient CLL8 after 0 days of ibrutinib treatment

Organism:
Homo sapiens
Source name:
PBMCs_CLL patient after 0 days of ibrutinib treatment
Platform:
GPL20301
Series:
GSE111014 GSE111015
Download data
Sample
Accession:
GSM3020402
ID:
303020402
6.

scRNA-seq on PBMCs from patient CLL6 after 30 days of ibrutinib treatment

Organism:
Homo sapiens
Source name:
PBMCs_CLL patient after 30 days of ibrutinib treatment
Platform:
GPL20301
Series:
GSE111014 GSE111015
Download data
Sample
Accession:
GSM3020401
ID:
303020401
7.

scRNA-seq on PBMCs from patient CLL6 after 280 days of ibrutinib treatment

Organism:
Homo sapiens
Source name:
PBMCs_CLL patient after 280 days of ibrutinib treatment
Platform:
GPL20301
Series:
GSE111014 GSE111015
Download data
Sample
Accession:
GSM3020400
ID:
303020400
8.

scRNA-seq on PBMCs from patient CLL6 after 120 days of ibrutinib treatment

Organism:
Homo sapiens
Source name:
PBMCs_CLL patient after 120 days of ibrutinib treatment
Platform:
GPL20301
Series:
GSE111014 GSE111015
Download data
Sample
Accession:
GSM3020399
ID:
303020399
9.

scRNA-seq on PBMCs from patient CLL6 after 0 days of ibrutinib treatment

Organism:
Homo sapiens
Source name:
PBMCs_CLL patient after 0 days of ibrutinib treatment
Platform:
GPL20301
Series:
GSE111014 GSE111015
Download data
Sample
Accession:
GSM3020398
ID:
303020398
10.

scRNA-seq on PBMCs from patient CLL5 after 30 days of ibrutinib treatment

Organism:
Homo sapiens
Source name:
PBMCs_CLL patient after 30 days of ibrutinib treatment
Platform:
GPL20301
Series:
GSE111014 GSE111015
Download data
Sample
Accession:
GSM3020397
ID:
303020397
11.

scRNA-seq on PBMCs from patient CLL5 after 150 days of ibrutinib treatment

Organism:
Homo sapiens
Source name:
PBMCs_CLL patient after 150 days of ibrutinib treatment
Platform:
GPL20301
Series:
GSE111014 GSE111015
Download data
Sample
Accession:
GSM3020396
ID:
303020396
12.

scRNA-seq on PBMCs from patient CLL5 after 0 days of ibrutinib treatment

Organism:
Homo sapiens
Source name:
PBMCs_CLL patient after 0 days of ibrutinib treatment
Platform:
GPL20301
Series:
GSE111014 GSE111015
Download data
Sample
Accession:
GSM3020395
ID:
303020395
13.

scRNA-seq on PBMCs from patient CLL1 after 120 days of ibrutinib treatment

Organism:
Homo sapiens
Source name:
PBMCs_CLL patient after 120 days of ibrutinib treatment
Platform:
GPL20301
Series:
GSE111014 GSE111015
Download data
Sample
Accession:
GSM3020394
ID:
303020394
14.

scRNA-seq on PBMCs from patient CLL1 after 0 days of ibrutinib treatment

Organism:
Homo sapiens
Source name:
PBMCs_CLL patient after 0 days of ibrutinib treatment
Platform:
GPL20301
Series:
GSE111014 GSE111015
Download data
Sample
Accession:
GSM3020393
ID:
303020393
15.

ATAC-seq on PBMCs from patient CLL8 on day 3 of ibrutinib treatment, NK cells

Organism:
Homo sapiens
Source name:
PBMCs_CLL patient_day 3 of ibrutinib treatment_NK cells
Platform:
GPL20301
Series:
GSE111013 GSE111015
Download data: BIGWIG, NARROWPEAK
Sample
Accession:
GSM3020392
ID:
303020392
16.

ATAC-seq on PBMCs from patient CLL8 on day 0 of ibrutinib treatment, NK cells

Organism:
Homo sapiens
Source name:
PBMCs_CLL patient_day 0 of ibrutinib treatment_NK cells
Platform:
GPL20301
Series:
GSE111013 GSE111015
Download data: BIGWIG, NARROWPEAK
Sample
Accession:
GSM3020391
ID:
303020391
17.

ATAC-seq on PBMCs from patient CLL8 on day 3 of ibrutinib treatment, Mono cells

Organism:
Homo sapiens
Source name:
PBMCs_CLL patient_day 3 of ibrutinib treatment_Mono cells
Platform:
GPL20301
Series:
GSE111013 GSE111015
Download data: BIGWIG, NARROWPEAK
Sample
Accession:
GSM3020390
ID:
303020390
18.

ATAC-seq on PBMCs from patient CLL8 on day 0 of ibrutinib treatment, Mono cells

Organism:
Homo sapiens
Source name:
PBMCs_CLL patient_day 0 of ibrutinib treatment_Mono cells
Platform:
GPL20301
Series:
GSE111013 GSE111015
Download data: BIGWIG, NARROWPEAK
Sample
Accession:
GSM3020389
ID:
303020389
19.

ATAC-seq on PBMCs from patient CLL8 on day 030 of ibrutinib treatment, CLL cells

Organism:
Homo sapiens
Source name:
PBMCs_CLL patient_day 030 of ibrutinib treatment_CLL cells
Platform:
GPL20301
Series:
GSE111013 GSE111015
Download data: BIGWIG, NARROWPEAK
Sample
Accession:
GSM3020388
ID:
303020388
20.

ATAC-seq on PBMCs from patient CLL8 on day 3 of ibrutinib treatment, CLL cells

Organism:
Homo sapiens
Source name:
PBMCs_CLL patient_day 3 of ibrutinib treatment_CLL cells
Platform:
GPL20301
Series:
GSE111013 GSE111015
Download data: BIGWIG, NARROWPEAK
Sample
Accession:
GSM3020387
ID:
303020387
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