GEO DataSets

(Submitter supplied) Background: Conflicting results have been reported about the role of the two-component sensor and transcriptional regulator DosS/DosR, controlling the expression of the dormancy DosR regulon, for in vivo virulence of M. tuberculosis. Here, we have used a new approach to further analyze the relevance of the dosRS system, by driving DosR (Rv3133c) expression under the control of a constitutive promoter (phsp60). more...

Organism:

Mycobacterium tuberculosis

Type:

Expression profiling by array

Platforms:

GPL9901 GPL9900

20 Samples

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(Submitter supplied) An estimated two billion persons are latently infected with Mycobacterium tuberculosis. The host factors that initiate and maintain this latent state and the mechanisms by which M. tuberculosis survives within latent lesions are compelling but unanswered questions. One such host factor may be nitric oxide (NO), a product of activated macrophages that exhibits antimycobacterial properties. Evidence for the possible significance of NO comes from murine models of tuberculosis showing progressive infection in animals unable to produce the inducible isoform of NO synthase and in animals treated with a NO synthase inhibitor. more...

Organism:

Mycobacterium tuberculosis

Type:

Expression profiling by array

Platforms:

GPL9901 GPL8561

131 Samples

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(Submitter supplied) Material is transferred from microtiter plate wells to the slide surface by an automated print head

Organism:

Mycobacterium tuberculosis

2 Series

23 Samples

Download data: ADF