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Items: 1 to 20 of 20707

1.

The RNA-Binding Protein DDX39B Promotes Colorectal Adenocarcinoma Progression by Stabilizing DCLK1

(Submitter supplied) As an RNA-binding protein (RBP), DDX39B increased the stability of DCLK1-B mRNA, a variant highly expressed in colorectal cancer known to promote cancer stemness, thereby augmenting its protein expression. Notably, silencing of DCLK1-B effectively abrogated the pro-metastatic effects induced by DDX39B overexpression.
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platform:
GPL24676
6 Samples
Download data: TXT
Series
Accession:
GSE296923
ID:
200296923

2.

Single-cell sequencing of plasma cell mastitis

(Submitter supplied) Single-cell sequencing of plasma cell mastitis
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platform:
GPL24676
1 Sample
Download data: MTX, TSV
Series
Accession:
GSE270755
ID:
200270755

3.

NOTCH1 reverses immune suppression in small cell lung cancer through reactivation of STING [scRNA-seq]

(Submitter supplied) Downregulation of antigen presentation and lack of immune infiltration are defining features of small cell lung cancer (SCLC) limiting response to immune checkpoint blockade (ICB), While a high MHC Class I, immune-inflamed subset benefits from ICB, underlying mechanisms of immune response in SCLC have yet to be elucidated. Here we show that in the landmark IMpower133 clinical trial high, but not low, NOTCH1 expression is significantly associated with longer survival with the addition of ICB to chemotherapy among ~80% of SCLC patients with neuroendocrine-enriched tumors (ASCL1-enriched, HR 0.39, P=0.0012; NEUROD1-enriched, HR 0.44, P=0.024). more...
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platform:
GPL24676
3 Samples
Download data: H5
Series
Accession:
GSE244946
ID:
200244946

4.

Altered gene expression by C1orf106 in endometrial cancer cells.

(Submitter supplied) Chromosome 1 open reading frame 106 (C1orf106) has been shown to be elevated in lung adenocarcinoma. However, its expression and function in endometrial cancer (EC) are totally unknown. To explore the role of C1orf106 in EC, we analyzed the gene expression in HEC-1A cells with or without C1orf106 knockdown.
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platform:
GPL24676
6 Samples
Download data: TXT
Series
Accession:
GSE298672
ID:
200298672

5.

RBM25 depletion suppresses colon cancer progression through regulating alternative splicing of MNK2

(Submitter supplied) To explore the molecular mechanism of RBM25 depletion in inhibiting colon cancer progression,we performed high-throughput mRNA sequencing (mRNA-seq) in HCT116 cells with RBM25 knockdown.
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platform:
GPL24676
4 Samples
Download data: TXT
Series
Accession:
GSE245341
ID:
200245341

6.

Loss of RBM45 inhibits breast cancer progression by reducing the SUMOylation of IRF7 to promote IFNB1 transcription

(Submitter supplied) Type I interferons exhibit anti-proliferative and anti-cancer activities, but their regulatory mechanisms in cancer have not been fully elucidated. RNA binding proteins are master orchestrators of gene expression regulation and are closely related to tumor progression. Here we show that the upregulated RNA binding protein RBM45 correlates with poor prognosis in breast cancer. Depletion of RBM45 suppresses breast cancer progression both in cultured cells and xenograft mouse models. more...
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platform:
GPL24676
3 Samples
Download data: XLSX
Series
Accession:
GSE244361
ID:
200244361

7.

Identification of splicing factors signature predicting prognosis risk and the mechanistic roles of novel oncogenes in HNSCC

(Submitter supplied) Head and neck squamous cell carcinoma (HNSCC) is the most frequent subtype of head and neck cancer generally with a poor prognosis and limited treatment options due to its highly heterogeneous malignancy. In this study, we screened functional splicing regulatory RNA binding proteins (RBPs) that are closely related with prognosis of patients with HNSCC and showed significant expression difference between HNSCC tumors and normal tissues. more...
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platform:
GPL24676
8 Samples
Download data: XLSX
Series
Accession:
GSE243085
ID:
200243085

8.

Genome-wide maps of chromatin state in U251 cells expressing VASN.

(Submitter supplied) Chromatin immunoprecipitation DNA-sequencing (ChIP-seq) for VASN in U251 cells expressing VASN.
Organism:
Homo sapiens
Type:
Genome binding/occupancy profiling by high throughput sequencing
Platform:
GPL24676
1 Sample
Download data: BW, NARROWPEAK
Series
Accession:
GSE206827
ID:
200206827

9.

The Cdc42 effector and non-receptor tyrosine kinase, ACK defines a distinct STAT5 transcription signature in a chronic myeloid leukaemia cell model

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing
Platform:
GPL24676
30 Samples
Download data: NARROWPEAK
Series
Accession:
GSE206524
ID:
200206524

10.

The Cdc42 effector and non-receptor tyrosine kinase, ACK defines a distinct STAT5 transcription signature in a chronic myeloid leukaemia cell model [CUTnRUN]

(Submitter supplied) Activated Cdc42-associated kinase (ACK) is a Rho family effector that is widely implicated in cancer. This work investigates how ACK affects the signal transducer and activators of transcription (STAT) family. ACK is shown to interact with STAT5 in the K562 CML cell line, and contribute to the pool of nuclear phosphorylated STAT5. By Cleavage Under Targets and Release Using Nuclease (CUT&RUN) and RNA-sequencing experiments using ACK KO K562 cells we have identified ACK driven STAT5 transcriptional targets. more...
Organism:
Homo sapiens
Type:
Genome binding/occupancy profiling by high throughput sequencing
Platform:
GPL24676
24 Samples
Download data: NARROWPEAK
Series
Accession:
GSE206522
ID:
200206522

11.

The Cdc42 effector and non-receptor tyrosine kinase, ACK defines a distinct STAT5 transcription signature in a chronic myeloid leukaemia cell model [RNA-Seq]

(Submitter supplied) Activated Cdc42-associated kinase (ACK) is a Rho family effector that is widely implicated in cancer. This work investigates how ACK affects the signal transducer and activators of transcription (STAT) family. ACK is shown to interact with STAT5 in the K562 CML cell line, and contribute to the pool of nuclear phosphorylated STAT5. By Cleavage Under Targets and Release Using Nuclease (CUT&RUN) and RNA-sequencing experiments using ACK KO K562 cells we have identified ACK driven STAT5 transcriptional targets.
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platform:
GPL24676
6 Samples
Download data: TXT
Series
Accession:
GSE206520
ID:
200206520

12.

TRPML3 regulates expression of development-related neuronal genes, and augments starvation-induced autophagy mediated transcriptional regulation in HEK cells

(Submitter supplied) Autophagy (self-eating) involves sorting of cargo like aggregated or misfolded proteins and damaged organelles, and their degradation via the endo-lysosomal system. It is a conserved process that is crucial in survival, cell stress response, and differentiation. Transient Receptor Potential Mucolipin-3 (TRPML3) is an endolysosomal calcium channel largely implicated in the mechanisms of endocytosis and autophagy. more...
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platform:
GPL24676
12 Samples
Download data: CSV
Series
Accession:
GSE300275
ID:
200300275

13.

m5C-MeRIP-seq of HHL5 cells

(Submitter supplied) We discovered the YBX1 in the lipid-induced particles assembled by DDX49, YBX1 is an m5C reader and constitutively associates with Timp2 mRNA in hepatocytes, we examined whether their association was dependent on the m5C modification of Timp2 mRNA, then we performed m5C-MeRIP-seq.
Organism:
Homo sapiens
Type:
Other
Platform:
GPL24676
4 Samples
Download data: XLSX
Series
Accession:
GSE299800
ID:
200299800

14.

Age-associated Tissue Organization Shifts Retinal Pigmented Epithelium Actomyosin Plasticity in Phagocytosis

(Submitter supplied) Mechanical homeostasis in healthy tissues relies on a dynamic balance of mechanical properties essential for maintaining tissue integrity and function. Over time, this integrity decays due to structural reorganization from extracellular remodelling or an imbalance of cell death and proliferation. This is particularly challenging in postmitotic tissues such as the retina, where lack of proliferation requires age-dependent structural adaptation. more...
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platform:
GPL24676
8 Samples
Download data: CSV
Series
Accession:
GSE297557
ID:
200297557

15.

AEBP1-GLI1 pathway attenuates the FACT complex dependency of bladder cancer cell survival.

(Submitter supplied) AEBP1 expression predicts a poor prognosis of bladder cancer patients, while its role has not been fully understood. We here show that the expression of AEBP1 was correlated with GLI transcriptional factors, leading to limit the SSRP1/SUPT16H (FACT) complex-dependency of bladder cancer cells.
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platform:
GPL24676
6 Samples
Download data: TXT
Series
Accession:
GSE288105
ID:
200288105

16.

Modularity of OCT4 underlies its functional diversity in reprogramming and embryonic development [ATAC-seq]

(Submitter supplied) Amongst the multiple cell fates orchestrated by OCT4, its ability to maintain pluripotency is thought to underpin reprogramming. How OCT4 drives pluripotency from diverse cellular contexts is unclear. By systematically dissecting OCT4, we find that reprogramming requires OCT4 domains dispensable for pluripotency maintenance and development throughout gastrulation but important for the embryo competence to develop through late gestation. more...
Organism:
Homo sapiens
Type:
Genome binding/occupancy profiling by high throughput sequencing
Platform:
GPL24676
7 Samples
Download data: BW
Series
Accession:
GSE287206
ID:
200287206

17.

Modularity of OCT4 underlies its functional diversity in reprogramming and embryonic development [RNA-seq]

(Submitter supplied) Amongst the multiple cell fates orchestrated by OCT4, its ability to maintain pluripotency is thought to underpin reprogramming. How OCT4 drives pluripotency from diverse cellular contexts is unclear. By systematically dissecting OCT4, we find that reprogramming requires OCT4 domains dispensable for pluripotency maintenance and development throughout gastrulation but important for the embryo competence to develop through late gestation. more...
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platform:
GPL24676
5 Samples
Download data: TXT
Series
Accession:
GSE286895
ID:
200286895

18.

RNF126 Promotes Endoplasmic Reticulum Stress in Fetal Growth Restriction via Ubiquitination-Mediated Degradation of the MYH9/MYH10 Complex

(Submitter supplied) Fetal growth restriction (FGR) stands as a prominent cause of neonatal morbidity and mortality, yet its underlying mechanisms remain elusive. Through a multi-omics analysis of the human placentas, including quantitative proteomics and ubiquitination-modified proteomics, our team find that the E3 ligase Ring finger protein 126 (RNF126) might be a potentially pivotal protein in the development of FGR. more...
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platform:
GPL24676
6 Samples
Download data: TXT
Series
Accession:
GSE285829
ID:
200285829

19.

Surgical and blood-based minimal residual disease in patients with ovarian cancer after frontline therapy: Clinical outcomes and translational opportunities [Spatial Transcriptomics]

(Submitter supplied) Minimal residual disease (MRD) after frontline treatment of advanced stage ovarian cancer remains a longstanding barrier to cure. We investigated the prognostic and translational value of MRD detection by second look laparoscopy (SLL) and circulating tumor DNA (ctDNA) at the completion of frontline therapy. Patients with high-grade epithelial ovarian cancer with complete clinical response to frontline therapy who underwent SLL and plasma collection for ctDNA were included. more...
Organism:
Homo sapiens
Type:
Other
Platform:
GPL24676
4 Samples
Download data: MTX, TIFF, TSV
Series
Accession:
GSE284100
ID:
200284100

20.

LINE-1 transposable elements regulate the exit of human pluripotency and early brain development [snRNA-seq]

(Submitter supplied) The mechanisms underlying primate-specific genetic programs during early human development remain poorly understood. Long interspersed nuclear element 1 (L1) is the most abundant transposable element in the human genome and represents a vast source of divergent genetic information in hominoid genomes, yet its contribution to human development is largely unknown. Using multiomics profiling, we show here that thousands of hominoid-specific L1 loci are expressed in human induced pluripotent stem cells and cerebral organoids. more...
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platform:
GPL24676
19 Samples
Download data: MTX, TSV
Series
Accession:
GSE284086
ID:
200284086

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