U.S. flag

An official website of the United States government

Format
Items per page
Sort by

Send to:

Choose Destination

Search results

Items: 1 to 20 of 318064

1.

The histone H3 lysine 36 demethylase KDM2A/FBXL11 is essential for germ cell development in male mice

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing; Methylation profiling by high throughput sequencing
Platforms:
GPL24247 GPL19057 GPL17021
56 Samples
Download data: BW
Series
Accession:
GSE214682
ID:
200214682
2.

Metastatic site influences driver gene function in pancreatic cancer [[InVitro ATAC-Seq]]

(Submitter supplied) Driver gene mutations can increase the metastatic potential of the primary tumor, but their role in sustaining tumor growth at metastatic sites is poorly understood. A paradigm of such mutations is inactivation of SMAD4 – a transcriptional effector of TGFβ signaling – which is a hallmark of multiple gastrointestinal malignancies. SMAD4 inactivation mediates TGFβ’s remarkable anti- to pro-tumorigenic switch during cancer progression and can thus influence both tumor initiation and metastasis. more...
Organism:
Mus musculus
Type:
Genome binding/occupancy profiling by high throughput sequencing
Platform:
GPL17021
6 Samples
Download data: BW
Series
Accession:
GSE299635
ID:
200299635
3.

Metastatic site influences driver gene function in pancreatic cancer [InVitro RNA-Seq]

(Submitter supplied) Driver gene mutations can increase the metastatic potential of the primary tumor, but their role in sustaining tumor growth at metastatic sites is poorly understood. A paradigm of such mutations is inactivation of SMAD4 – a transcriptional effector of TGFβ signaling – which is a hallmark of multiple gastrointestinal malignancies. SMAD4 inactivation mediates TGFβ’s remarkable anti- to pro-tumorigenic switch during cancer progression and can thus influence both tumor initiation and metastasis. more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL17021
8 Samples
Download data: CSV
Series
Accession:
GSE299633
ID:
200299633
4.

Early synergy between IFNγ-inducible Gbp4 and Irgb6 in the olfactory bulb contributes to experimental cerebral malaria pathology

(Submitter supplied) Cerebral malaria (CM) is a severe and often fatal complication of Plasmodium falciparum infection. Although much progress has been made in understanding CM, the precise pathogenesis remains elusive. The olfactory bulb (OB) has emerged as a critical site of immunopathology in experimental cerebral malaria (ECM) models, but its contribution to disease progression is not fully understood. To investigate the molecular mechanisms driving early ECM pathogenesis, we conducted transcriptomic profiling of the OB to identify key gene signatures associated with disease onset. more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL17021
11 Samples
Download data: CSV
Series
Accession:
GSE282591
ID:
200282591
5.

Hypoxia-inducible Factor 1α Mediated Lactylation to Enhance Inflammatory Response during Hypoxia induced lung dysfunction [RNA-seq]

(Submitter supplied) Hypoxia can result in tissue dysfunction, metabolic alterations, and structural damage within the pulmonary tissue, thereby impacting lung ventilation and air exchange. The identification of Hypoxia-inducible factor (Hif) 1α as a pivotal mediator in the inflammatory cascade subsequent to hypoxia induction has been established. However, the mechanism remains elusive. To delve deeper into this phenomenon, we have developed a murine model of sustained hypoxia and utilized nanocarriers for the delivery of lentivirus Hif-1α for knockdown purposes. more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL17021
9 Samples
Download data: XLSX
Series
Accession:
GSE269141
ID:
200269141
6.

Gene expression changes in Ctcf-deleted mouse uterus on gestational day 4 (GD4).

(Submitter supplied) We specifically deleted Ctcf in the female reproductive tract using the Pgr-Cre driver. To portray the molecular mechanism for Ctcf function in uterus, uterine tissues were collected from Ctcf f/f and Ctcf d/d mice on GD4 and subjected to RNA-seq analysis.
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL17021
6 Samples
Download data: TXT, XLSX
Series
Accession:
GSE299181
ID:
200299181
7.

Moesin deficiency leads to microglia-mediated synaptic pruning and social abnormality: a post-GWAS functional genomics study

(Submitter supplied) Genome-wide association studies (GWAS) implicated a noncoding antisense RNA designated as MSNP1AS in susceptibility to autism spectrum disorders (ASD). MSNP1AS binds to and downregulates the Moesin (MSN) transcript and is highly overexpressed in postmortem cerebral cortex of individuals with ASDs. However, the mechanistic link between Moesin loss in vivo and ASD-related phenotypic traits remains enigmatic. more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL17021
2 Samples
Download data: MTX, TSV
Series
Accession:
GSE293405
ID:
200293405
8.

Effect of depletion of PARP2 on gene expression in 3 month-old pancreas from Ela-myc mice

(Submitter supplied) Pancreatic cancer represents one of the most lethal tumours, characterised by an immunosuppressive microenvironment and a lack of cytotoxic immune cell infiltrates, which confers resistance to immunotherapy. Here, we demonstrate that the deletion of Poly(ADP-ribose)polymerase 2 (PARP2) delays tumour progression in c-Myc-driven and KRas-driven mouse models of pancreatic cancer. Transcriptomic analysis revealed that the absence of PARP2 induces an enrichment of pathways associated with anti-tumor immune responses and genomic instability. more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL17021
6 Samples
Download data: TXT
Series
Accession:
GSE277055
ID:
200277055
9.

Multi-omics analysis of the epigenetic effects of lipopolysaccharide-induced inflammation in Type II Pneumocytes

(Submitter supplied) Chronic inflammation plays a central role in the pathogenesis of many lung diseases including asthma, SARS-COVID19, obstructive pulmonary disease (COPD), and lung cancer. Lipopolysaccharide (LPS) is an inflammatory agent produced by most Gram-negative bacteria and found in cigarette smoke. In a mouse model of inflammation, inhalation exposure to LPS induced COPD and increased the size and the multiplicity of lung tumors induced by tobacco-specific nitrosamines. more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing; Methylation profiling by high throughput sequencing
Platforms:
GPL21626 GPL17021
36 Samples
Download data: BED, CSV, TXT
Series
Accession:
GSE275769
ID:
200275769
10.

Phenotypic screens for SIRPA expression reveal RAB21 as a general regulator of macrophage surface identity

(Submitter supplied) Factors influencing the macrophage surfaceome define macrophage identity and behaviour. Here, we use genome-wide phenotypic screens to identify genes affecting the accessibility and surface expression of macrophage SIRPA. Our data are consistent with previous evidence but also implicate QPCTL in cis CD47-SIRPA interactions. We also identify endolysosomal factors encoded by RAB21 and members of the CCC and WASH complexes as modulators of SIRPA expression. more...
Organism:
Homo sapiens; Mus musculus
Type:
Other
Platforms:
GPL17021 GPL16791
61 Samples
Download data: TXT
Series
Accession:
GSE297202
ID:
200297202
11.

Exploring the effect of aging, TNFα, and RBM25 on the gene expresssion of inner ear

(Submitter supplied) Purpose: The goals of this study are to explore the effect aging on gene expression of the inner ear. And the effect of RBM25 and TNFα on the gene expression on inner ear organod are explored.
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL17021
24 Samples
Download data: TXT
Series
Accession:
GSE273939
ID:
200273939
12.

RNA-seq profiling of C/EBPβ-overexpressing myoblasts [differentiating myoblasts]

(Submitter supplied) We previously identified C/EBPβ as an inhibitor of myogenic differentiation and its role in muscle satellite cell’s self-renewal and quiescence. C/EBPβ is regulated during the transition from proliferation to differentiation in myoblasts and that overexpression of C/EBPβ inhibits myocyte differentiation. To identify the molecular mechanism by which C/EBPβ inhibits myogenic differentiation, we performed RNA-seq on C/EBPβ-overexpressing differentiating myoblasts.
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL17021
4 Samples
Download data: TXT
Series
Accession:
GSE152053
ID:
200152053
13.

NAT10 in Diabetic Cardiomyopathy in Exercise

(Submitter supplied) To investigate the role of NAT10 in diabetic cardiomyopathy in response to exercise, 6-week-old NAT10 floxed mice were fed a high-fat diet (HFD) for 18 weeks followed by low doses of STZ injections, some of the mice were then injected with AAV9-cTnT-Cre to knockout NAT10 in cardiomyocytes. There mice were then subjected to either sedentary or eight weeks of treadmill exercise. We then performed gene expression profiling analysis using data obtained from RNA-seq from RNAs pulldown with an ac4C antibody.
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL17021
4 Samples
Download data: XLS
Series
Accession:
GSE291716
ID:
200291716
14.

The effect of deletion of muscarinic acetylcholine receptor 4 in Math1 expressing cells in the small intestine

(Submitter supplied) The muscarinic acetylcholine receptor 4 was inducibly deleted in Math1 expressing lineages and alterations in gene expression evaluated by bulk RNA sequencing
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL17021
5 Samples
Download data: TXT
Series
Accession:
GSE269646
ID:
200269646
15.

Single-cell RNA sequencing reveals liver immune cell-endothelial cell interactions in mice with carbon tetrachloride-induced liver fibrosis

(Submitter supplied) Liver fibrosis is a common pathological process in chronic liver disease, reflecting the advanced stage of the disease. Liver endothelial cells (ECs), especially liver sinusoidal endothelial cells (LSECs), are recognized as critical modulators of liver homeostasis and play essential roles in the recruitment and function of liver immune cells. However, the mechanism of liver EC injury and the occurrence of intercellular crosstalk in liver fibrosis are still unclear. more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL17021
2 Samples
Download data: TAR
Series
Accession:
GSE268846
ID:
200268846
16.

Gene expression during PMA-induced neutrophil NETs formation with or without knockout of neutrophils of Src kinase

(Submitter supplied) Src kinase has functions in regulating reactive oxygen species production, degranulation, NETs formation, integrin activation, and migration to human infection sites in neutrophils. RNA sequencing was performed by extracting mRNA from PMA-induced mouse neutrophils with or without Src kinase knockout(Src fl/fl S100a8 Cre or Src fl/fl mice). Gene enrichment analysis by Genomes (Reactome) identified RAF/MAP kinase cascade in the top ten significantly changed pathways.
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL17021
6 Samples
Download data: XLS
Series
Accession:
GSE251972
ID:
200251972
17.

Vagal neuroimmune axis modulates heart failure by limiting monocyte-derived inflammatory CCRL2 macrophage II

(Submitter supplied) Autonomic neuronal dysfunction is associated with heart failure (HF). Here, we report that targeted vagal nerve stimulation (VNS) using optogenetics attenuates cardiac remodelling and HF induced by pressure overload. Unbiased approaches revealed that VNS decreased the proportion of the Ccrl2+ macrophage subset, which derived from myeloid monocytes and exhibited a distinct tumour necrosis factor-alpha (TNFα)-responsive, pro-hypertrophic, and profibrotic signature. more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL17021
6 Samples
Download data: CSV
Series
Accession:
GSE296255
ID:
200296255
18.

Ufl1 deficiency causes skin pigmentation by u-pregulation of Endothelin-1

(Submitter supplied) Ufmylation (UFM1 modification) is a newly identified ubiquitin-like modification system involved in numerous cellular processes. However, the regulatory mechanisms and biological functions of this modification remain mostly unknown. We have recently reported that Ufmylation family genes have frequent somatic copy number alterations in human cancer including melanoma, suggesting involvement of Ufmylation in skin function and disease. more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL17021
6 Samples
Download data: TXT
Series
Accession:
GSE205159
ID:
200205159
19.

Inference of emergent spatio-temporal processes from single-cell sequencing reveals feedback between de novo DNA methylation and chromatin condensates

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing
Platform:
GPL17021
576 Samples
Download data: COV
Series
Accession:
GSE166226
ID:
200166226
20.

Inference of emergent spatio-temporal processes from single-cell sequencing reveals feedback between de novo DNA methylation and chromatin condensates [RNA-seq]

(Submitter supplied) Recent breakthroughs in single-cell genomics allow probing molecular states of cells with unprecedented detail along the sequence of the DNA. Biological function relies, however, on emergent processes in the three-dimensional space of the nucleus, such as droplet formation through phase separation. Here, we use single-cell multi-omics sequencing to develop a theoretical framework to rigorously map epigenome profiling along the DNA sequence onto a description of the emergent spatial dynamics in the nucleus. more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL17021
288 Samples
Download data: TXT
Series
Accession:
GSE166225
ID:
200166225
Format
Items per page
Sort by

Send to:

Choose Destination

Supplemental Content

db=gds|term=GPL17021[Accession]|query=1|qty=86|blobid=MCID_684e04170549615056c9d171|ismultiple=true|min_list=5|max_list=20|def_tree=20|def_list=|def_view=|url=/Taxonomy/backend/subset.cgi?|trace_url=/stat?
   Taxonomic Groups  [List]
Tree placeholder
    Top Organisms  [Tree]

Find related data

Search details

See more...

Recent activity

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

See more...