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Items: 1 to 20 of 318448

1.

Xist upstream deletion impairs topological contacts of Xist locus and affects Xist coating/expression and autosomal gene expression [ChIP-Seq]

(Submitter supplied) In this study, we have investigated the role of Xist upstream region located near the Xist-TAD boundary in maintenance of imprinted X-chromosome inactivation in extraembryonic endoderm stem cells (XEN). We found that deletion of Xist upstream region(~6Kb) leads to the alterations of Xist intra-TAD contacts and upregulate Xist expression. Moreover, it impaired the interactions of the Xist locus across X-chromosomes and autosomes. more...
Organism:
Mus musculus
Type:
Genome binding/occupancy profiling by high throughput sequencing
Platform:
GPL17021
11 Samples
Download data: BW
Series
Accession:
GSE245641
ID:
200245641
2.

Xist upstream deletion impairs topological contacts of Xist locus and affects Xist coating/expression and autosomal gene expression [RNA-Seq]

(Submitter supplied) In this study, we have investigated the role of Xist upstream region located near the Xist-TAD boundary in maintenance of imprinted X-chromosome inactivation in extraembryonic endoderm stem cells (XEN). We found that deletion of Xist upstream region(~6Kb) leads to the alterations of Xist intra-TAD contacts and upregulate Xist expression. Moreover, it impaired the interactions of the Xist locus across X-chromosomes and autosomes. more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platforms:
GPL24247 GPL17021
9 Samples
Download data: TXT
Series
Accession:
GSE245640
ID:
200245640
3.

The effect of antibiotic induced imbalance of gut microbiota on the expression profile of miRNA in circulating extracellular vesicles

(Submitter supplied) By measuring the miRNA expression profile in the blood circulating extracellular vesicles of mice with antibiotic induced intestinal microbiota imbalance through miRNA seq, it was determined that intestinal microbiota imbalance leads to significant changes in the miRNA expression profile in the blood circulating extracellular vesicles
Organism:
Mus musculus
Type:
Non-coding RNA profiling by high throughput sequencing
Platform:
GPL17021
2 Samples
Download data: XLSX
Series
Accession:
GSE234626
ID:
200234626
4.

Xist upstream deletion leads to dysregulation of Xist and autosomal gene expression

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing; Other
Platforms:
GPL24247 GPL17021
26 Samples
Download data: BW
Series
Accession:
GSE245643
ID:
200245643
5.

Identification of Neuritin 1 as a local metabolic regulator of brown adipose tissue.

(Submitter supplied) Brown adipose tissue (BAT) plays a key role in metabolic homeostasis through its thermogenic effects and the secretion of regulatory molecules. Here we report that RAP250 haploinsufficiency stimulates BAT in mice, thus contributing to a decrease in fat accumulation. Local in vivo AAV-mediated RAP250 silencing in BAT reduces body weight and fat mass and enhances glucose oxidation, thereby indicating that RAP250 participates in the regulation of BAT metabolic activity. more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL17021
7 Samples
Download data: XLSX
Series
Accession:
GSE295442
ID:
200295442
6.

Proton-secreting cells modulate mucosal immune surveillance in the male reproductive tract

(Submitter supplied) We identify clearly distinct transcriptomic signatures between clear cells from the caput, corpus, and cauda regions after LPS intravasal epididymal injection compared to control (saline injection).
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL17021
18 Samples
Download data: TXT
Series
Accession:
GSE294713
ID:
200294713
7.

Divergently evolved FOXA1 mutations drive prostate tumorigenesis or therapy-resistant intra-luminal plasticity

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Mus musculus
Type:
Genome binding/occupancy profiling by high throughput sequencing; Expression profiling by high throughput sequencing
Platforms:
GPL24247 GPL17021
113 Samples
Download data: BED, BW, H5
Series
Accession:
GSE282406
ID:
200282406
8.

Divergent FOXA1 mutations drive prostate tumorigenesis or therapy-resistant intra-luminal plasticity [RNA-Seq]

(Submitter supplied) FOXA1 is recurrently altered in hormone-driven malignancies, with activating hotspot mutations detected in 10-40% of primary prostate cancers based on ethnicity. Yet, the tumorigenic potential and pathobiology of FOXA1 remain unexplored in vivo. Here, we generated and characterized knock-in mouse models harboring FOXA1 mutant transgenes that represent distinct classes of activating mutations. Our findings reveal that FOXA1 class 1 mutations (i.e., wing 2 alterations) in a Trp53-null background, drive high-grade, invasive luminal adenocarcinoma with full penetrance by 40 weeks of age. more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL17021
38 Samples
Download data: CSV
Series
Accession:
GSE280835
ID:
200280835
9.

Divergently evolved FOXA1 mutations drive prostate tumorigenesis or therapy-resistant intra-luminal plasticity [ChIP-seq]

(Submitter supplied) FOXA1 is recurrently altered in hormone-driven malignancies, with activating hotspot mutations detected in 10-40% of primary prostate cancers based on ethnicity. Yet, the tumorigenic potential and pathobiology of FOXA1 remain unexplored in vivo. Here, we generated and characterized knock-in mouse models harboring FOXA1 mutant transgenes that represent distinct classes of activating mutations. Our findings reveal that FOXA1 class 1 mutations (i.e., wing 2 alterations) in a Trp53-null background, drive high-grade, invasive luminal adenocarcinoma with full penetrance by 40 weeks of age. more...
Organism:
Mus musculus
Type:
Genome binding/occupancy profiling by high throughput sequencing
Platform:
GPL17021
17 Samples
Download data: BED, BW
Series
Accession:
GSE280834
ID:
200280834
10.

FABP7 expression modulates the response of astrocyte to induced endotoxemia.

(Submitter supplied) To investigate the effect of knocking down FABP7 expression in a mouse model of endotoxemia
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL17021
6 Samples
Download data: TXT
Series
Accession:
GSE279612
ID:
200279612
11.

Identifying RRP1-bound RNA sequences in IL-1β stimulated BMDMs

(Submitter supplied) How RRP1 control RNA processing and regulation in macrophage inflammation is important. Here is the screening for potential RRP1-bound RNA sequences using RIP-seq in bone marrow derived macrophages (BMDMs).
Organism:
Mus musculus
Type:
Other
Platform:
GPL17021
9 Samples
Download data: TXT
Series
Accession:
GSE271948
ID:
200271948
12.

The RNA binding protein Bcas2 is necessary for antibody class switch in mammalian genomes

(Submitter supplied) In children, hyper-IgM syndrome type 1 (HIGM1) is a type of severe antibody disorder, the pathogenesis of which remains unclear. Here we report for the first time that breast cancer amplified sequence 2 (BCAS2), known as an RNA-binding protein, regulates the antibody class transition processes through alternative splicing (AS). Based on integrated analysis of the whole genome sequence and CLIP-seq data, we revealed that BCAS2 regulates AS through binding to the GAAGAA motif of target genes in B cells. more...
Organism:
Mus musculus; Homo sapiens
Type:
Expression profiling by high throughput sequencing; Other
Platforms:
GPL17021 GPL16791
14 Samples
Download data: BW
Series
Accession:
GSE271398
ID:
200271398
13.

Metastatic immunoediting in breast cancer cells

(Submitter supplied) During the metastatic process, most of the disseminated tumor cells fail to adapt to new tissue conditions upon arrival and die, resulting in a selection of the fittest cells. Among these hurdles, the immune system’s anti-tumor activity is one of the main barriers of metastatic colonization. Among the different Metastasis-initiating cells (MICs) properties, immune evasion stands out as one of the most necessary traits leading metastasis. more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL17021
7 Samples
Download data: TXT
Series
Accession:
GSE260481
ID:
200260481
14.

In vivo study of the Tim3-loss in breast cancer cells during metastasis

(Submitter supplied) In metastasis, the existence tumor cells overcoming the immune system during early organ seeding is crucial, yet the dynamics of tumor-immune interactions during micrometastasis remain unclear. Examining the immune selective pressure in breast cancer (BC) mouse models, we unexpectedly found TIM3 among the most upregulated genes in metastatic surviving BC cells. The selection of TIM3+ tumor cells, was specifically occurring during early seeding of micrometastasis, escaping the immune attack and acquiring stemness. more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL17021
4 Samples
Download data: TXT
Series
Accession:
GSE260480
ID:
200260480
15.

Trajectory analysis reveals an uncommitted neuroblastic state in MYCN-driven neuroblastoma development

(Submitter supplied) We analyzed the transcriptomic features of spontaneous regression in pre-cancerous neuroblasts using Th-MYCN mice, an animal model that closely resembles human neuroblastoma. Single-cell transcriptomic analysis of ganglion tissues from Th-MYCN mice was conducted to elucidate the cellular and molecular underpinnings. Trajectory analysis of pre-cancerous neuroblasts revealed a distinct subtype we designated as "uncommitted" cells, characterized by the expression of neuronal genes, indicative of a semi-differentiated state. more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL17021
12 Samples
Download data: MTX, RDS, TSV
Series
Accession:
GSE247665
ID:
200247665
16.

Effect of acute and chronic ATF6 activation on gene expression in the colonic epithelium, in specific pathogen-free and germ-free mice.

(Submitter supplied) The induction of endoplasmic reticulum unfolded protein responses (UPRER) contributes to cancer development and progression. We recently linked microbiota-related triggers to the tumor-promoting role of signal transducer activating transcription factor 6 (ATF6) in the colon. Here we substantiate the clinical relevance of ATF6 and related bacterial genera in colorectal cancer patient cohorts. Spatial and longitudinal bacterial profiling in ATF6 transgenic mice (nATF6IEC) identified tumor-initiating and tumor-progressing shifts in the mucosa-associated microbiota. more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL17021
37 Samples
Download data: TXT
Series
Accession:
GSE247122
ID:
200247122
17.

Provoking the Immunotherapy Efficacy of Renal Medullary Carcinoma

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Homo sapiens; Mus musculus
Type:
Expression profiling by high throughput sequencing
Platforms:
GPL17021 GPL16791
48 Samples
Download data
Series
Accession:
GSE240845
ID:
200240845
18.

Provoking the Immunotherapy Efficacy of Renal Medullary Carcinoma [RNA-seq II]

(Submitter supplied) Renal medullary carcinoma (RMC) predominantly afflicts young individuals of African descent harboring sickle hemoglobinopathies such as sickle cell disease (SCD) or sickle cell anemia (SCA). RMC is refractory to targeted and immune therapy strategies used for other renal cell carcinomas. We have demonstrated that RMC is resistant to immune checkpoint inhibition despite harboring an inflamed tumor immune microenvironment. more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL17021
20 Samples
Download data: TXT
Series
Accession:
GSE240827
ID:
200240827
19.

The role of endothelial Zeb2 in the progression of non-alcoholic fatty liver disease

(Submitter supplied) Zinc-Finger E-Box-binding Homeobox (Zeb)2 has an anti-angiogenic and anti-fibrotic role in liver endothelial cells, but its role in non-alcoholic fatty liver disease remains unknown. We performed RNA sequencing on endothelial cells sorted from wild-type mice and mice lacking Zeb2 specifically in endothelial cells kept on a western or standard diet to identify RNA expression changes and gene ontology terms affected by knock-out of endothelial Zeb2, western diet challenge, or the combination of both challenges.
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL17021
23 Samples
Download data: TXT
Series
Accession:
GSE224595
ID:
200224595
20.

Obox1 deficiency induceds subfertility in female mice

(Submitter supplied) Obox1 was considered to be a maternal factor participates in oogenesis and follicle development, but its function remains largely undefined. In this study, we demonstrated that Obox1-null female mice displayed subfertility as evidenced by decreased litter size. Obox1 deficiency resulted in less oocytes production. The levels of female sex hormones and gonadotropins, especially luteinizing hormone (LH), were significantly decreased both in ovaries and serum at diestrus. more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL17021
4 Samples
Download data: FPKM_TRACKING
Series
Accession:
GSE207448
ID:
200207448
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