GEO DataSets

(Submitter supplied) A one of general treatments of patient with acute promyelocytic leukemia (APL) is performed a high dose rate of total-body irradiation therapy. However, the appearance of radioresistant cell that is rarely expressed induces a harmful outcome even performing radiotherapy. We have been established a radioresistant APL cell model (Resistant type), and some characteristics was clarified. But little is known as to the micro RNAs (miRs) expression profile in this cell. more...

Organism:

Homo sapiens

Type:

Non-coding RNA profiling by array

Platform:

GPL15159

8 Samples

Download data: TXT

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Homo sapiens

Type:

Non-coding RNA profiling by array; Expression profiling by array

Platforms:

GPL15159 GPL17077

70 Samples

Download data: TXT

(Submitter supplied) We used miRNA expression arrays and integrated analysis to study mucoepidermoid carcinomas (MEC) to identify potential drivers involved with its pathogenesis. Normal salivary glands were used as controls.

Organism:

Homo sapiens

Type:

Non-coding RNA profiling by array

Platform:

GPL15159

31 Samples

Download data: TXT

(Submitter supplied) Biomarkers of tumour response to radiotherapy could help in optimising cancer treatment. In this study, we focus on identifying changes in extracellular miRNA as a biomarker of radiation-induced damage to human colorectal cancer cells. HCT116 cells were exposed to increasing doses of X-rays, and extracellular miRNAs were analysed by microarray. The results were correlated with frequencies of micronuclei. more...

Organism:

Homo sapiens; Mus musculus

Type:

Non-coding RNA profiling by array

Platform:

GPL15159

16 Samples

Download data: TXT, XLSX

(Submitter supplied) Antigen presenting cells (APCs) regulate the balance of our immune response towards microbes. Whereas immunogenic APCs boost inflammation and activate lymphocytes, the highly plastic cells can switch into a tolerogenic/suppressive phenotype that dampens and resolves the response. Thereby the initially mediated inflammation seems to prime the switch of APCs while the strength of activation determines the grade of the suppressive phenotype. more...

Organism:

Homo sapiens

Type:

Non-coding RNA profiling by array

Platform:

GPL15159

6 Samples

Download data: TXT

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Homo sapiens

Type:

Non-coding RNA profiling by array

Platform:

GPL15159

384 Samples

Download data: TXT

(Submitter supplied) We set out to demonstrate the logistic feasibility of careful study design in microarray studies and the level of scientific benefits it can provide, in comparison with post-hoc data adjustment such as normalization, for the purpose of reducing the impact of handling effects on the accuracy and reproducibility of microarray data analysis. Towards this end, we conducted a study of microRNA expression using endometroid endometrial cancer tumors (n=96) and serous ovarian cancer tumors (n=96) that were all primary, untreated, and collected in 2000-2012 at Memorial Sloan Kettering Cancer Center. more...

Organism:

Homo sapiens

Type:

Non-coding RNA profiling by array

Platform:

GPL15159

192 Samples

Download data: TXT

(Submitter supplied) We set out to demonstrate the logistic feasibility of careful study design in microarray studies and the level of scientific benefits it can provide, in comparison with post-hoc data adjustment such as normalization, for preventing confounding handling effects and improving the accuracy and reproducibility of disease-relevant biomarker detection. Towards this end, we conducted a study of microRNA expression using endometroid endometrial cancer tumors (n=96) and serous ovarian cancer tumors (n=96) that were all primary, untreated, and collected in 2000-2012 at Memorial Sloan Kettering Cancer Center. more...

Organism:

Homo sapiens

Type:

Non-coding RNA profiling by array

Platform:

GPL15159

192 Samples

Download data: TXT

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Homo sapiens

Type:

Expression profiling by array; Non-coding RNA profiling by array

Platforms:

GPL17077 GPL15159

14 Samples

Download data: TXT

(Submitter supplied) Transcriptional profiling and microRNA profiling of paired PDX and derived cell line MT-CHC01 upon ET-743 treatement Intrahepatic cholangiocarcinoma (ICC) is an aggressive and lethal malignancy with limited therapeutic options. ET-743 has a high antitumor activity in preclinical models of biliary tract carcinoma (BTC), being a promising alternative treatment. Here, we studied the effect of ET-743 at transcriptomic level on an ICC patient derived xenograft (PDX) and on the derived cell line, MT-CHC01. more...

Organism:

Homo sapiens

Type:

Non-coding RNA profiling by array

Platform:

GPL15159

8 Samples

Download data: TXT

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Homo sapiens

Type:

Methylation profiling by array; Non-coding RNA profiling by array

Platforms:

GPL15159 GPL13534

66 Samples

Download data: IDAT, TXT

(Submitter supplied) Cervical cancer and a subset of anogenital and head-and-neck carcinomas are caused by persistent infection with high-risk types of the human papillomavirus (hrHPV). Early stages of hrHPV-induced carcinogenesis can be faithfully mimicked in vitro. A major hallmark of hrHPV-transformed cells is their ability to grow anchorage independently, an oncogenic trait known to depend on inactivation of tumour suppressor genes. more...

Organism:

Homo sapiens

Type:

Non-coding RNA profiling by array

Platform:

GPL15159

60 Samples

Download data: TXT

(Submitter supplied) We analyzed microRNA profiles in archival FFPE sentinel node biopsy (SNB) from melanoma patients with different outcomes. Tumor-negative SNB (N), and tumor-positive SNB from patients with (PP) or without disease progression at 5 years follow-up (PN) were analyzed.

Organism:

Homo sapiens

Type:

Non-coding RNA profiling by array

Platform:

GPL15159

24 Samples

Download data: TXT

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Homo sapiens

Type:

Expression profiling by array; Non-coding RNA profiling by array

Platforms:

GPL14550 GPL15159

182 Samples

Download data: TXT

(Submitter supplied) To study the molecular signatures of mRNAs and miRNAs which can potentially act as a prognostic biomarkers in pancreatobiliary and intestinal types of periampullary adenocarcinomas

Organism:

Homo sapiens

Type:

Non-coding RNA profiling by array

Platform:

GPL15159

89 Samples

Download data: TXT

(Submitter supplied) Monocytes and granulocytes were isolated from blood of TB patients and household contacts. RNA was isolated and microRNA expression was measured using microarrays.

Organism:

Homo sapiens

Type:

Non-coding RNA profiling by array

Platform:

GPL15159

32 Samples

Download data: TXT

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Homo sapiens

Type:

Non-coding RNA profiling by array; Expression profiling by array; Methylation profiling by genome tiling array

Platforms:

GPL13534 GPL15159 GPL20652

102 Samples

Download data: IDAT, TXT

(Submitter supplied) To gain insights into the in vivo function of miRNAs in the context of periodontitis, we examined the occurrence of miRNAs in healthy and diseased gingival tissues and validated their in silico-predicted targets through mRNA profiling using whole-genome microarrays in the same specimens. Eighty-six individuals with periodontitis contributed 198 gingival papillae: 158 'diseased' (bleeding-on-probing, PD > 4 mm, and AL ≥ 3 mm) and 40 'healthy' (no bleeding, PD ≤ 4 mm, and AL ≤ 2 mm). more...

Organism:

Homo sapiens

Type:

Non-coding RNA profiling by array

Platform:

GPL15159

200 Samples

Download data: TXT

(Submitter supplied) The study was undertaken to identify microRNAs differently expressed by intestinal type of gastric cancer using miRNA microarray. The miRNA expression in the intestinal type of gastric cancer depending on H. pylori infection suggest that different gastric cancer pathogenesis could be exist between H. pylori-positive and -negative gastric cancer.

Organism:

Homo sapiens

Type:

Non-coding RNA profiling by array

Platform:

GPL15159

32 Samples

Download data: TXT

(Submitter supplied) The aims of the study were investigated whether expression of urinary cell-free miRNAs would be different between prostate cancer (CaP) patients and non-cancer subjects with benign prostatic hyperplasia (BPH). Urinary cell-free miRNAs will provide potential benefits for detecting CaP, and virus-encoded hsv1-miR-H18 and hsv2-miR-H9-5p could be the important urinary diagnostic markers of CaP. It would be interesting because this is the first report about virus-encoded miRNAs related to CaP, and two miRNAs showed good diagnostic performance even in patients with PSA gray zone.

Organism:

Homo sapiens

Type:

Non-coding RNA profiling by array

Platform:

GPL15159

19 Samples

Download data: TXT