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Items: 1 to 20 of 228

1.

Hypotensive major health effect of Rubus ulmifolius Schott. and Artemisia campestris L. highlighted by nutrigenomic and cardiovascular studies

(Submitter supplied) To evaluate the antihypertensive effect of Artemisia campestris and Rubus ulmifolius, we conducted a nutrigenomic analysis to examine the changes induced by the administration of the aqueous extracts of these plants on gene expression in mice. Cardiovascular effects were discussed together with antitumoral, anti-inflammatory, antimicrobial and eating behavior effects.
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL10333
9 Samples
Download data: GPR
Series
Accession:
GSE251733
ID:
200251733

PubMed Analyze with GEO2R

2.

Effects of choline deficiency in mouse photoreceptor cell line 661W

(Submitter supplied) Although mutations in human patatin-like phospholipase PNPLA6 are associated with hereditary retinal degenerative diseases, its mechanistic action in the retina is poorly understood. Here, we uncover the molecular mechanism by which PNPLA6 dysfunction disturbs retinal homeostasis and visual function. PNPLA6, by acting as a phospholipase B, regulates choline mobilization from phosphatidylcholine and subsequent choline turnover for phosphatidylcholine regeneration in retinal pigment epithelial (RPE) cells. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL10333
2 Samples
Download data: TXT
Series
Accession:
GSE253529
ID:
200253529

PubMed Analyze with GEO2R

3.

Lipid-orchestrated paracrine circuit coordinates mast cell maturation through functional interaction with fibroblasts [fibroblast]

(Submitter supplied) Interaction of mast cells (MCs) with fibroblasts is essential for MC maturation within tissue microenvironments, although the underlying mechanism is incompletely understood. Through a phenotypic screening of >30 mouse lines deficient in lipid-related genes, we found that deletion of the lysophosphatidic acid (LPA) receptor LPA1, like that of the phospholipase PLA2G3, the prostaglandin D2 (PGD2) synthase L-PGDS, or the PGD2 receptor DP1, impairs MC maturation and thereby anaphylaxis. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL10333
4 Samples
Download data: TXT
Series
Accession:
GSE253361
ID:
200253361

PubMed Analyze with GEO2R

4.

Lipid-orchestrated paracrine circuit coordinates mast cell maturation through functional interaction with fibroblasts [mast cell]

(Submitter supplied) Interaction of mast cells (MCs) with fibroblasts is essential for MC maturation within tissue microenvironments, although the underlying mechanism is incompletely understood. Through a phenotypic screening of >30 mouse lines deficient in lipid-related genes, we found that deletion of the lysophosphatidic acid (LPA) receptor LPA1, like that of the phospholipase PLA2G3, the prostaglandin D2 (PGD2) synthase L-PGDS, or the PGD2 receptor DP1, impairs MC maturation and thereby anaphylaxis. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL10333
6 Samples
Download data: TXT
Series
Accession:
GSE253356
ID:
200253356

PubMed Analyze with GEO2R

5.

Effect of group III phospholipase A2 deletion on gene expression in bronchial epithelial cells in an antigen-induced asthma model.

(Submitter supplied) Asthma is a chronic inflammatory disease of the airways characterized by recurrent episodes of airway obstruction, hyperresponsiveness, remodeling, and eosinophilia. Phospholipase A2s (PLA2s), which release fatty acids and lysophospholipids from membrane phospholipids, have been implicated in exacerbating asthma by generating pro-asthmatic lipid mediators, but an understanding of the association between individual PLA2 subtypes and asthma is still incomplete. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL10333
4 Samples
Download data: TXT
Series
Accession:
GSE249135
ID:
200249135

PubMed Similar studies Analyze with GEO2R

6.

Effect of group III phospholipase A2 deletion in antigen-induced asthma modeled lung

(Submitter supplied) Asthma is a chronic inflammatory disease of the airways characterized by recurrent episodes of airway obstruction, hyperresponsiveness, remodeling, and eosinophilia. Phospholipase A2s (PLA2s), which release fatty acids and lysophospholipids from membrane phospholipids, have been implicated in exacerbating asthma by generating pro-asthmatic lipid mediators, but an understanding of the association between individual PLA2 subtypes and asthma is still incomplete. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL10333
4 Samples
Download data: TXT
Series
Accession:
GSE249134
ID:
200249134

PubMed Similar studies Analyze with GEO2R

7.

Differential gene expression in brain tissues of Pla2g2e-deficient and wild-type mice

(Submitter supplied) To investigate the gene expression in brain tissues of Pla2g2e-deficient and wild-type mice, we performed gene expression profiling analysis using data obtained from Microarray of brain tissues collected from neuron-specific Pla2g2e-deficient and wild-type mice.
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL10333
6 Samples
Download data: TXT, XLSX
Series
Accession:
GSE232174
ID:
200232174

Analyze with GEO2R

8.

Differential gene expression in brain tissues of Pla2g2e-deficient and wild-type mice on day 3 after ischemic stroke onset

(Submitter supplied) To investigate the gene expression in brain tissues of Pla2g2e-deficient and wild-type mice on day 3 after ischemic stroke onset, we performed gene expression profiling analysis using data obtained from Microarray of brain tissues from Pla2g2e-deficient and wild-type mice.
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL10333
7 Samples
Download data: TXT
Series
Accession:
GSE230996
ID:
200230996

Analyze with GEO2R

9.

Expression profile of primary murine astrocyte-enriched cultures (AEC) exposed to oxygen-glucose deprivation

(Submitter supplied) Microarray analysis was used to identify genes that fluctuated by oxygen-glucose deprivation of mouse astrocytes. Astrocyte-enriched cultures were generated from mixed glial cultures of mice and compared to control samples with 15 hours of oxygen-glucose deprivation. The results showed that 173 genes were upregulated with Fold change >10, P < 0.05. Both Nr4a1 and Nr4a3, which is an orphan nuclear receptor subfamily and known as an immediate early gene, were upregulated.
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL10333
4 Samples
Download data: TXT
Series
Accession:
GSE224577
ID:
200224577

PubMed Full text in PMC Similar studies Analyze with GEO2R

10.

Molecular and Physiological Functions of PACAP in Sweat Secretion

(Submitter supplied) Sweat has a critical role in human body, including thermoregulation and maintenance of skin environment and health. Hyperhidrosis and anhidrosis are caused by abnormalities in sweat secretion resulting in severe skin conditions (pruritus and erythema). Bioactive peptide, pituitary adenylate cyclase-activating polypeptide (PACAP) was isolated and identified to activate adenylate cyclase in pituitary cells. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL10333
8 Samples
Download data: TXT
Series
Accession:
GSE223124
ID:
200223124

PubMed Full text in PMC Similar studies Analyze with GEO2R

11.

Gene expressional changes in control or adult reprogramming cardiomyocytes

(Submitter supplied) To investigate gene expressional changes in adult control or early reprogramming cardiomyocytes.
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL10333
4 Samples
Download data: TXT, XLS
Series
Accession:
GSE169035
ID:
200169035

PubMed Full text in PMC Similar studies Analyze with GEO2R

12.

Hepatic Phosphatidylcholine Catabolism Driven by PNPLA7 and PNPLA8 Supplies Endogenous Choline to Replenish the Methionine Cycle with Methyl Groups

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL10333
10 Samples
Download data: TXT
Series
Accession:
GSE217139
ID:
200217139

PubMed Similar studies Analyze with GEO2R

13.

Hepatic Phosphatidylcholine Catabolism Driven by PNPLA7 and PNPLA8 Supplies Endogenous Choline to Replenish the Methionine Cycle with Methyl Groups III

(Submitter supplied) Choline supplies methyl groups for regeneration of methionine and the methyl donor S-adenosylmethionine in the liver. Here we demonstrate that the catabolism of membrane phosphatidylcholine (PC) into water-soluble glycerophosphocholine (GPC) by the phospholipase/lysophospholipase PNPLA8-PNPLA7 axis enables endogenous choline stored in hepatic PC to be utilized in methyl metabolism. PNPLA7-deficient mice show marked decreases in hepatic GPC, choline, and several metabolites related to the methionine cycle, accompanied by various signs of methionine insufficiency including growth retardation, hypoglycemia, hypolipidemia, increased energy consumption, reduced adiposity, increased FGF21, and an altered epigenetic methylation landscape. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL10333
4 Samples
Download data: TXT
Series
Accession:
GSE217137
ID:
200217137

PubMed Similar studies Analyze with GEO2R

14.

Hepatic Phosphatidylcholine Catabolism Driven by PNPLA7 and PNPLA8 Supplies Endogenous Choline to Replenish the Methionine Cycle with Methyl Groups II

(Submitter supplied) Choline supplies methyl groups for regeneration of methionine and the methyl donor S-adenosylmethionine in the liver. Here we demonstrate that the catabolism of membrane phosphatidylcholine (PC) into water-soluble glycerophosphocholine (GPC) by the phospholipase/lysophospholipase PNPLA8-PNPLA7 axis enables endogenous choline stored in hepatic PC to be utilized in methyl metabolism. PNPLA7-deficient mice show marked decreases in hepatic GPC, choline, and several metabolites related to the methionine cycle, accompanied by various signs of methionine insufficiency including growth retardation, hypoglycemia, hypolipidemia, increased energy consumption, reduced adiposity, increased FGF21, and an altered epigenetic methylation landscape. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL10333
4 Samples
Download data: TXT
Series
Accession:
GSE217136
ID:
200217136

PubMed Similar studies Analyze with GEO2R

15.

Hepatic Phosphatidylcholine Catabolism Driven by PNPLA7 and PNPLA8 Supplies Endogenous Choline to Replenish the Methionine Cycle with Methyl Groups I

(Submitter supplied) Choline supplies methyl groups for regeneration of methionine and the methyl donor S-adenosylmethionine in the liver. Here we demonstrate that the catabolism of membrane phosphatidylcholine (PC) into water-soluble glycerophosphocholine (GPC) by the phospholipase/lysophospholipase PNPLA8-PNPLA7 axis enables endogenous choline stored in hepatic PC to be utilized in methyl metabolism. PNPLA7-deficient mice show marked decreases in hepatic GPC, choline, and several metabolites related to the methionine cycle, accompanied by various signs of methionine insufficiency including growth retardation, hypoglycemia, hypolipidemia, increased energy consumption, reduced adiposity, increased FGF21, and an altered epigenetic methylation landscape. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL10333
2 Samples
Download data: TXT
Series
Accession:
GSE217135
ID:
200217135

PubMed Similar studies Analyze with GEO2R

16.

Hepatic thyroid hormone signalling modulates glucose homeostasis through the regulation of GLP-1 production via bile acid-mediated FXR antagonism

(Submitter supplied) A greater understanding of the glucose homeostasis mediated by glucagon-like peptide-1 (GLP-1) will facilitate the development of novel glucose-lowering treatments. Here we show that improved glucose metabolism in hypothyroid mice after treatment of T3, the active form of thyroid hormone (TH), is accompanied with increased GLP-1 production and insulin secretion. Treatment of a GLP-1 receptor antagonist is able to attenuate the observed T3 effect on insulin and glucose levels, suggesting that GLP-1 is critically involved in the regulation of glucose homeostasis by T3. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL10333
2 Samples
Download data: TXT
Series
Accession:
GSE184055
ID:
200184055

PubMed Full text in PMC Similar studies Analyze with GEO2R

17.

Transcriptome profiling of murine overexpression of p65/RelA mutants III

(Submitter supplied) Effect of overexpression of murine p65/RelA and D361 mutant and resulting fragments in DA1-3B Bcr-Abl+ murine cell lines
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL10333
17 Samples
Download data: TXT
Series
Accession:
GSE135137
ID:
200135137

PubMed Full text in PMC Similar studies Analyze with GEO2R

18.

Transcriptome profiling of murine overexpression of p65/RelA mutants II

(Submitter supplied) Effect of overexpression of murine p65/RelA and D361 mutant and resulting fragments in B16 Bcr-Abl+ murine cell lines
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL10333
20 Samples
Download data: TXT
Series
Accession:
GSE135136
ID:
200135136

PubMed Full text in PMC Similar studies Analyze with GEO2R

19.

Trancriptome profiling of murine overexpression of p65/RelA mutants

(Submitter supplied) Effect of overexpression of murine p65/RelA and D361 mutant and resulting fragments in DA1-3B Bcr-Abl+ murine cell lines
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL10333
24 Samples
Download data: TXT
Series
Accession:
GSE98437
ID:
200098437

PubMed Full text in PMC Similar studies Analyze with GEO2R

20.

Metformin in the ileum

(Submitter supplied) C57BL/6J male mice were treated with or without metformin
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL10333
4 Samples
Download data: TXT
Series
Accession:
GSE201039
ID:
200201039

Analyze with GEO2R

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