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Items: 1 to 20 of 48

1.
Full record GDS4219

Peripheral blood monocyte CD16 + and Cd16- subsets from healthy donors

Analysis of peripheral blood monocyte (Mo) CD16 (FcγRIII) subsets CD16- and CD16+. Increase in circulating CD16+ Mo have been reported in inflammatory pathologies (sepsis/HIV infection). Results provide insight into developmental and functional relationship between CD16+ and CD16- Mo subsets.
Organism:
Homo sapiens
Type:
Expression profiling by array, count, 2 cell type sets
Platform:
GPL570
Series:
GSE16836
8 Samples
Download data: CEL, CHP
2.
Full record GDS1710

bHLH transcription factor MyoD knockdown effect on myoblast differentiation

Analysis of C2C12 myoblast cell line following RNAi knockdown of the bHLH transcription factor MyoD. RNA prepared from cells after 1, 3, and 6 days of myogenic differentiation in DMEM medium supplemented with 2% horse serum. Results identify targets of MyoD.
Organism:
Homo sapiens; Mus musculus
Type:
Expression profiling by array, log2 ratio, 3 time sets
Platform:
GPL2677
Series:
GSE3014
6 Samples
Download data
DataSet
Accession:
GDS1710
ID:
1710
3.

Knockout of miR-221 and miR-222 reveals overlapping and specific function between paralogous miRNAs

(Submitter supplied) MicroRNAs (miRNAs) regulate the expression of mRNAs through sequence-specific binding into their 3′ untranslated region (UTR). The seed sequence of miRNAs is the key determinant to recognize the target sites. The paralogous miRNAs, which share the same seed sequences but differ in their 3′ parts, are known to regulate largely overlapping group of miRNAs. However, there is still no study which analyzes the functional difference among paralogous miRNAs. more...
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platform:
GPL16791
8 Samples
Download data: TXT
Series
Accession:
GSE80064
ID:
200080064
4.

Genome-wide analysis of SNB19 and SHSY5Y cells with single or double knockdown of SDHD and CDKN1C or SLC22A18

(Submitter supplied) Analysis of knockdown of SDHD with or without knockdown of CDKN1C or SLC22A18 at gene expression level. The hypothesis tested in this study was to determine whether the gene expression signature following SDHD knockdown together with SLC22A18 or CDKN1C more closely resembles the signature found in tumors than the signature resulting from SDHD knockdown alone.
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL10558
24 Samples
Download data: IDAT, TXT, XLSX
Series
Accession:
GSE80968
ID:
200080968
5.

Gene expression analysis of human cell lines established from normal patient's fibroblast and BWS patients with known mutations in the CDKN1C and KCNQ1OT1

(Submitter supplied) Gene expression profiling was carried out in one normal human fibroblast cell line established from normal people and three different cell lines established from BWS patients to characterize the molecular mechanisms relevant to the etiology of BWS and tumor development. Whole-transcriptome sequencing of three BWS fibroblastic cell lines was established from patients with mutation in the CDKN1C mutation (CDKN1C+ cell line), and loss of methylation in the KCNQ1OT1 region (KvDMR+ cell line: with KvDMR molecular defect, and KvDMR- cell line: absence of KvDMR molecular defect but it had some clinical signs of BWS)
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platform:
GPL11154
4 Samples
Download data: CSV
Series
Accession:
GSE69737
ID:
200069737
6.

Conservation of parental genomic imprinting by cortex generated from embryonic stem cells [RRBS-seq]

(Submitter supplied) In vitro cortex generated from embryonic stem cells (ESCs) is a model system to investigate corticogenesis and a promising tool for cortical therapy. A fundamental question that has implications for understanding corticogenesis and for using stem cells therapeutically is to determine whether in vitro cortex reproduces some fine-tuned epigenetic modifications that are important for corticogenesis and function in vivo such as parent-of-origin dependent DNA methylation and expression of imprinted genes (IGs). more...
Organism:
Mus musculus
Type:
Methylation profiling by high throughput sequencing
Platform:
GPL13112
26 Samples
Download data: TXT
Series
Accession:
GSE75485
ID:
200075485
7.

Differential Gene Expression Profiles of PASMCs Induced by Quercetin under Hypoxia

(Submitter supplied) As the critical step of pathogenesis during hypoxic pulmonary arterial hypertension (PAH) vascular remodeling is closely associated with pulmonary arterial smooth muscle cell (PASMC) alterations induced by hypoxia that include persistent vasoconstriction, abnormal proliferation and PASMC resistance to apoptosis. Quercetin is a flavonoid compound extracted from green plants that inhibits proliferation, induces apoptosis, arrests the cell cycle, and rescues the constriction of PASMCs, but the underlying mechanisms remain poorly understood. more...
Organism:
Rattus norvegicus
Type:
Expression profiling by array
Platform:
GPL7294
9 Samples
Download data: TXT
Series
Accession:
GSE72181
ID:
200072181
8.

Gene expression changes initiated by miR-34c in Dicer/Pten double knockout mouse serous epithelial cancer

(Submitter supplied) miR-34c inhibits Dicer/Pten double knockout mouse serous epithelial cancer cell proliferation by inducing cell cycle arrest and apoptosis. We found that miR-34c had a more dramatic effect on inhibiting tumor cell viability than let-7b. The action of miR-34c induced tumor cell cycle arrest in G1 phase and apoptosis and was accompanied with the regulation of key genes involved in cell proliferation and cell cycle G1/S transition. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL6887
6 Samples
Download data: TXT
Series
Accession:
GSE57493
ID:
200057493
9.

Expression data of mouse hematopoietic cells, Nr4a1/3 wild type and double mutant

(Submitter supplied) We investigate the cellular and molecular mechanisms of tumor suppression by NR4A1 and NR4A3, and show a cell intrinsic essential function in maintenance of hematopoietic stem cell (HSC) homeostasis. In the absence of Nr4a1/3, HSC lost quiescence, became highly proliferative leukemia-stem cell (LSC) that transplanted AML to recipient mice. We further revealed that loss of NR4A1/3 leads to deregulated expression of the key cell cycle regulator Cdkn1c (P57), c-Myc oncogene, and glucose metabolic genes leading to enhanced aerobic glycolysis or ‘Warburg effect’ in LSCs. Reintroduction of Nr4a1 in LSCs restored HSC quiescence, and reversed Nr4a1/3 deficiency induced P57 suppression and c-Myc overexpression. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL1261
6 Samples
Download data: CEL
Series
Accession:
GSE31042
ID:
200031042
10.

Knockdown of CDKN1C (p57kip2) and PHLDA2 results in developmental changes in bovine pre-implantation embryos

(Submitter supplied) Transcriptome of CDKN1C-siRNA-injected embryos were compared to sham-injected embryos using RNA-sequencing to determine the genes and pathways downstream of the silenced gene that may have been altered.
Organism:
Bos taurus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL15749
2 Samples
Download data: TXT
Series
Accession:
GSE42931
ID:
200042931
11.

Translational control in early adipogenesis

(Submitter supplied) In obesity, adipose tissue expands by increasing the volume of existing adipocytes (hypertrophy), increasing the number of small adipocytes (hyperplasia) or both. Much is known about transcriptional control during adipogenesis, including early events. However, translational control plays a pivotal role in many dynamic processes and we presume that it is also important for the control of adipogenesis, especially in the first hours after hormonal induction. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL7202
12 Samples
Download data: TXT
Series
Accession:
GSE29744
ID:
200029744
12.

Network inference tools for the human transcriptome

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL4044
424 Samples
Download data: TXT
Series
Accession:
GSE27871
ID:
200027871
13.

Gene expression profiles of 400 siRNA knocked down on HUVEC

(Submitter supplied) Gene regulatory networks inferred from RNA abundance data have generated significant interest. Several high-profile studies have suggested that gene networks may be useful for identifying molecular pathways related to development, human disease and drug action. However despite, this potential, gene network approaches are used relatively infrequently and their use generally requires input from specialist bioinformaticians. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL4044
400 Samples
Download data: TXT
Series
Accession:
GSE27869
ID:
200027869
14.

Gene expression profiles of splenocytes of CD22DE12 transgenic mice

(Submitter supplied) Splenocytes from nontransgenic control mice and transgenic mice were isolated and their gene expression profiles were compared to determine if the expression of the transgene results in any changes in regulation of gene expression. 12 differentially expressed genes were classified as the most discriminating genes, including TP53, NF2, MDM2, RAC1, APC, and STATB1 with tumor suppressor gene function as well as cell cycle regulatory genes CDKN1C, CCNG1, and NOTCH4
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL149
10 Samples
Download data: TXT
Series
Accession:
GSE23998
ID:
200023998
15.

Increased expression of Bcl11b in human transformed T cell lines leads to chemoresistance accompanied by G1 accumulation.

(Submitter supplied) ABSTRACT Background: The expression of BCL11B has been reported in normal and transformed cells derived from T-lymphocytes, neurons, keratinocytes and recently in a subset of squamous cell carcinomas. Despite the rapidly accumulating knowledge concerning Bcl11b biology, the contribution of this protein to normal or transformed cell homeostasis remains open. Methodology/Principal Findings: Here, by employing an overexpression strategy and cells endogenously expressing BCL11B we revealed formerly unidentified features of Bcl11b which shed some light on the potential involvement of the protein in tumor maintenance. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL570
2 Samples
Download data: CEL, CHP
Series
Accession:
GSE21382
ID:
200021382
16.

The gene profile of zebrafish guanine binding protein-like 2 (Gnl2) mutant embryos versus wild-type embryos at 22 hours post-fertilization

(Submitter supplied) Nucleostemin (NS), a member of a family of nucleolar GTP-binding proteins, is highly expressed in proliferating cells and implicated in the control of cell cycle progression, the maintenance of stem cells, and the regulation of cancer cells. The depletion of NS in cell lines and invertebrate animals has been demonstrated to result in defective ribosome biogenesis, while both depletion and overexpression of NS are able to stabilize the tumor suppressor p53 protein. more...
Organism:
Danio rerio
Type:
Expression profiling by array
Platform:
GPL2878
2 Samples
Download data: TIFF, TXT
Series
Accession:
GSE21134
ID:
200021134
17.

Rhabdoid Tumor: Gene Expression Clues to Pathogenesis and Potential Therapeutic Targets

(Submitter supplied) Rhabdoid tumors (RT) are aggressive tumors characterized by genetic loss of SMARCB1 (SNF5, INI-1), a component of the SWI/SNF chromatin remodeling complex. No effective treatment is currently available. This study seeks to shed light on the SMARCB1-mediated pathogenesis of RT and to discover potential therapeutic targets. Global gene expression of 10 RT was compared with 12 cellular mesoblastic nephromas, 16 clear cell sarcomas of the kidney, and 15 Wilms tumors. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL96
53 Samples
Download data: CEL, XLS
Series
Accession:
GSE11482
ID:
200011482
18.

Transcriptional profiling of CD16+ and CD16- peripheral blood monocytes from healthy individuals

(Submitter supplied) Human peripheral blood monocytes (Mo) consist of subsets distinguished by expression of CD16 (FCGRIII) and chemokine receptors. Classical CD16- Mo express CCR2 and migrate in response to CCL2, while a minor CD16+ Mo subset expresses CX3CR1 and migrates into tissues expressing CX3CL1. CD16+ Mo produce pro-inflammatory cytokines and are expanded in certain inflammatory conditions including HIV infection. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Dataset:
GDS4219
Platform:
GPL570
8 Samples
Download data: CEL, CHP
Series
Accession:
GSE16836
ID:
200016836
19.

Gene expression of Peg-interferon alfa-2b plus ribavirin in hepatitis C patients during the first 10 weeks of treatment

(Submitter supplied) Study of PBMC gene expression during the first 10 weeks of therapy with Pegylated-interferon-alfa2b (PegIntronTM) and ribavirin (administered by weight) in HCV patients. This study compared the kinetics of gene expression during the first 10 weeks of therapy with Pegylated-interferon-alfa2b (PegIntronTM) and ribavirin (administered by weight) in HCV patients with the recently completed Virahep C study (9999) in which Peginterferon-alfa2a and ribavirin was administered. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL96
152 Samples
Download data: CEL, CHP
Series
Accession:
GSE11342
ID:
200011342
20.

Array-comparative genomic hybridization by using DualChip® human cancer 1.1 arrays

(Submitter supplied) Tumors often harbor several genetic aberrations at both RNA and DNA level. Integration of expression data with copy number changes represents a powerful strategy to investigate genes involved in tumorigenesis. Here we describe a fluorescent array-based Comparative Genomic Hybridization protocol to be used on a commercial microarray platform optimized to detect cancer-related gene expression. This method will be valuable to use a single low-density array platform monitoring gene expression and copy number assessment in parallel. more...
Organism:
Homo sapiens
Type:
Genome variation profiling by array; Genome variation profiling by genome tiling array
Platforms:
GPL6745 GPL2873
4 Samples
Download data: TXT
Series
Accession:
GSE11225
ID:
200011225
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