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Items: 1 to 20 of 36

1.

miR-378a regulates keratinocyte responsiveness to IL-17A in psoriasis

(Submitter supplied) In 2019, our group performed small RNA-sequencing on keratinocytes isolated from lesional and non-lesional psoriasis skin as well as from healthy skin, and identified miRNAs with altered levels in psoriasis keratinocytes (Srivastava et al., 2019). One of the miRNAs we identified to be overexpressed in psoriasis keratinocytes was miR-378a-3p. In this study, we aimed to explore the regulation and function of miR-378a in keratinocytes and its potential role in psoriasis. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL16686
16 Samples
Download data: CEL
Series
Accession:
GSE164400
ID:
200164400
2.

Gene expression effects of PPAR-gamma serine 273 to alanine knock-in mutation in epididymal white adipose tissue

(Submitter supplied) Mice maintained on high-fat diet (Research Diets #D12492) for 37 weeks.
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL19057
8 Samples
Download data: TSV
Series
Accession:
GSE151030
ID:
200151030
3.

The Innate Immune Factor IRF3 Reduces Adipose Thermogenesis via ISG15-mediated Reprogramming of Cellular Metabolism

(Submitter supplied) Purpose: Interferon regulatory factor 3 (IRF3) is activated by pro-inflammatory cytokines, but its role in regulating adaptive thermogenesis and energy expenditure remains unclear. Here, we report that IRF3 as a negative transcription regulator of adaptive thermogenesis. Adipocyte-specific IRF3 knockout (FI3KO) attenuates HFD-induced obesity by increasing energy expenditure; further studies show that IRF3 suppresses adaptive thermogenesis through ISG15-mediated inhibition of glycolysis in adipocytes. more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL19057
12 Samples
Download data: TSV
Series
Accession:
GSE155019
ID:
200155019
4.

Adipocytes Fail to Maintain Cellular Identity During Obesity Due to Reduced PPARg Activity and Elevated TGFβ-SMAD Signaling

(Submitter supplied) Obesity due to overnutrition causes adipose tissue dysfunction, serving as a critical pathological step on the road to Type 2 diabetes (T2D) and other metabolic disorders. Here, we performed an unbiased investigation into the fundamental molecular mechanisms by which adipocytes transition to an unhealthy state during obesity. We fed NuTRAP (Nuclear tagging and Translating Ribosome Affinity Purification) mice crossed with Adipoq-Cre with chow or high fat diet (HFD) for 10 weeks and determined adipocyte-specific transcriptomic profiles by RNA-seq, active promoter and enhancer activities by H3K27ac ChIP-seq, and the PPARg cistrome by ChIP-seq. more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing
Platforms:
GPL17021 GPL19057
13 Samples
Download data: BW, TXT
Series
Accession:
GSE153120
ID:
200153120
5.

Integrative discovery of treatments for high-risk neuroblastoma

(Submitter supplied) Neuroblastoma (NB) cells exhibit a complex spectrum of pathway changes associated with oncogene activation, chromosome events, tumor micro-environment and super-enhancer states. So far, elucidating which pharmaceutical compounds could modulate the activation level of each known pathway in NB cells has not been feasible. We treated 2 patient-derived xenograft (PDX) NB cell lines with different chemical compounds, at 3 different doses (IC50, IC20, and IC10) and 2 time-points (6 and 24h). more...
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platform:
GPL21290
768 Samples
Download data: TXT
Series
Accession:
GSE120920
ID:
200120920
6.

Single cell RNA-seq shows cellular heterogeneity and lineage expansion in a mouse model of SHH-driven medulloblastoma support resistance to SHH inhibitor therapy

(Submitter supplied) Cellular diversity within tumors and reduced lineage commitment can undermine targeted therapy by increasing the probability of treatment-resistant populations. Using single-cell RNA-seq, we analyzed cellular diversity and lineage in medulloblastomas in transgenic, medulloblastoma-prone mice, and responses to the SHH-pathway inhibitor vismodegib.
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL21103
15 Samples
Download data: TXT
Series
Accession:
GSE129730
ID:
200129730
7.

Warming Induces Significant Reprogramming of Beige, but Not Brown, Adipocyte Cellular Identity

(Submitter supplied) Beige and brown adipocytes generate heat in response to reductions in ambient temperature. When warmed, both beige and brown adipocytes exhibit morphological ‘whitening’, but it is unknown whether or to what extent this represents a true shift in cellular identity. Using cell type-specific profiling in vivo, we uncover a unique paradigm of temperature-dependent epigenomic plasticity of beige, but not brown, adipocytes, with conversion from a brown to a white chromatin state. more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing
Platforms:
GPL17021 GPL19057
58 Samples
Download data: BW, TSV
Series
Accession:
GSE108077
ID:
200108077
8.

Characterizing the transcriptional profile of murine 3T3-L1 adipocytes with altered expression of Dnmt3a

(Submitter supplied) We report RNA-Seq data file from 3T3-L1 adipocytes following overexpression and knock-down of Dnmt3a
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL19057
12 Samples
Download data: TSV
Series
Accession:
GSE104508
ID:
200104508
9.

Transcriptional profile of brown adipose tissue (BAT) and white vastus lateralis (WV) from BATI4KO mice

(Submitter supplied) We report RNA-seq data from the brown fat and vastus muscles of mice lacking IRF4 in brown fat (BATI4KO) vs floxed littermate controls
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL19057
21 Samples
Download data: TSV
Series
Accession:
GSE103736
ID:
200103736
10.

BRCA1-mimetic compound NSC35446.HCl inhits IKKB expression by reducing estrogen receptor alpha occupancy in the IKKB promoter and inhibts NF-κB activity in anti-estrogen resitant human breast cells

(Submitter supplied) We previously identified small molecules that fit into a BRCA1-binding pocket within estrogen receptor-alpha (ER), mimic the ability of BRCA1 to inhibit ER activity (“BRCA1-mimetics”), and overcome antiestrogen resistance. One such compound, the hydrochloride salt of NSC35446 (“NSC35446.HCl”), also inhibited growth of antiestrogen-resistant LCC9 tumor xenografts. The purpose of this study was to investigate the down-stream effects of NSC35446.HCl and its mechanism of action. more...
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platform:
GPL16791
4 Samples
Download data: TXT
Series
Accession:
GSE101691
ID:
200101691
11.

A Molecular Census of Arcuate Hypothalamus and Median Eminence Cell Types

(Submitter supplied) Drop-seq and single cell sequencing of mouse arcuate nucleus and median eminence
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL19057
25 Samples
Download data: CSV
Series
Accession:
GSE90806
ID:
200090806
12.

A Molecular Census of Arcuate Hypothalamus and Median Eminence Cell Types

(Submitter supplied) Drop-seq and single cell sequencing of mouse arcuate nucleus and median eminence. Please see below link for searchable cluster-based gene expression.
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL19057
11 Samples
Download data: TXT
Series
Accession:
GSE93374
ID:
200093374
13.

Simultaneous transcriptional and epigenomic profiling from specific cell types within heterogeneous tissues in vivo

(Submitter supplied) This study introduces “NuTRAP”, a transgenic mouse that allows simultaneous isolation of cell type-specific translating mRNA and chromatin from complex tissues Using NuTRAP, we successfully characterize gene expression and epigenomic states of various adipocyte populations in vivo, To demonstrate general usefulness, we chateraterize histone states of in vivo hepatocytes.
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing
Platforms:
GPL19057 GPL16417 GPL17021
36 Samples
Download data: BW
Series
Accession:
GSE92590
ID:
200092590
14.

Characterising the transcriptional profile of murine 3T3-L1 adipocytes with altered expression of IRF3.

(Submitter supplied) The chronic inflammatory state that accompanies obesity is a major contributor to insulin resistance and other metabolic dysfunction features. Despite recent advances in our understanding of the cellular and secreted factors that promote the inflammatory milieu of obesity, we have much less insight into the transcriptional pathways that drive these processes. While most attention has focused on the canonical inflammatory transcription factor NF-KB, other potentially important factors exist, including members of the interferon regultory factor (IRF) family. more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL17021
18 Samples
Download data: TXT
Series
Accession:
GSE81193
ID:
200081193
15.

Physical interaction between mutant calreticulin and the thrombopoietin receptor is required for transformation of hematopoietic cells

(Submitter supplied) Somatic mutations in calreticulin (CALR) are present in approximately 40% of patients with myeloproliferative neoplasms (MPN). However, the mechanism by which mutant CALR is oncogenic is unknown. Here, we demonstrate that a megakaryocytic-specific MPN phenotype is induced when mutant CALR is over-expressed in mice and that the thrombopoietin receptor, MPL is required for mutant CALR driven transformation. more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL13112
12 Samples
Download data: TSV
Series
Accession:
GSE74890
ID:
200074890
16.

Transcriptional responses of mouse adipocytes during insulin resistance

(Submitter supplied) Insulin resistance is a sine qua non of Type 2 diabetes (T2D) and a frequent complication of multiple clinical conditions, including obesity, aging, and steroid use, among others. How such a panoply of insults can result in a common phenotype is incompletely understood. Furthermore, very little is known about the transcriptional and epigenetic basis of this disorder, despite evidence that such pathways are likely to play a fundamental role. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL1261
21 Samples
Download data: CEL
Series
Accession:
GSE62635
ID:
200062635
17.

Characterizing the profiles of histone markers in mouse adipocytes during insulin resistance

(Submitter supplied) Insulin resistance is a sine qua non of Type 2 diabetes (T2D) and a frequent complication of multiple clinical conditions, including obesity, aging, and steroid use, among others. How such a panoply of insults can result in a common phenotype is incompletely understood. Furthermore, very little is known about the transcriptional and epigenetic basis of this disorder, despite evidence that such pathways are likely to play a fundamental role. more...
Organism:
Mus musculus
Type:
Genome binding/occupancy profiling by high throughput sequencing
Platform:
GPL13112
66 Samples
Download data: TXT
Series
Accession:
GSE58491
ID:
200058491
18.

Characterizing the profiles of Ebf1 in mouse fat cells (ChIP-seq)

(Submitter supplied) ChIP-seq data from mouse adipocyte.
Organism:
Mus musculus
Type:
Genome binding/occupancy profiling by high throughput sequencing
Platform:
GPL13112
2 Samples
Download data: BED
Series
Accession:
GSE58330
ID:
200058330
19.

Characterizing the profiles of Ebf1 in mouse fat cells.

(Submitter supplied) gene expression data from mouse adipocyte, with and without Ebf1 knock-down
Organism:
Mus musculus
Type:
Expression profiling by array
Dataset:
GDS5285
Platform:
GPL1261
9 Samples
Download data: CEL
Series
Accession:
GSE58193
ID:
200058193
20.
Full record GDS5285

Early B-cell factor 1 depletion effect on mature adipocyte cell line

Analysis of mature 3T3-L1 adipocyte cells depleted for early B-cell factor 1 (EBF1). EBF1 is required in adipogenesis. Results provide insight into the role of EBF1 in mature adipocytes.
Organism:
Mus musculus
Type:
Expression profiling by array, transformed count, 3 agent, 2 protocol sets
Platform:
GPL1261
Series:
GSE58193
9 Samples
Download data: CEL
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