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Items: 1 to 20 of 800

1.

PCIF1-mediated deposition of 5-cap N6,2-O-dimethyladenosine in ACE2 and TMPRSS2 mRNA regulates susceptibility to SARS-CoV-2 infection

(Submitter supplied) We applied m6Am-exo-seq and RNA-seq on lung cancer to profile the differentially expressed genes and compared the results with m6A-exo-seq
Organism:
Homo sapiens
Type:
Other; Expression profiling by high throughput sequencing
Platform:
GPL24676
14 Samples
Download data: CSV
Series
Accession:
GSE208533
ID:
200208533
2.

Transcriptional Differences Between COVID-19 and Sepsis

(Submitter supplied) Although some studies reported the comprehensive mRNA expression analysis of coronavirus disease 2019 (COVID-19) using blood samples to understand its pathogenesis, the characteristics of RNA expression in COVID-19 and sepsis have not been compared. We compared the transcriptome expression of whole blood samples from patients with COVID-19 caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and patients with sepsis caused by other bacteria who entered the intensive care unit to clarify the COVID-19-specific RNA expression and understand its pathogenesis. more...
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platform:
GPL28038
27 Samples
Download data
Series
Accession:
GSE199816
ID:
200199816
3.

Transcriptome analysis of umbilical cord blood CD34+ cells of neonates delivered from SARS-CoV-2 infected and/or vaccinated mothers

(Submitter supplied) We report comparative transcriptome data of CD34+ cells derived from umbilical cord blood of neonates delivered from SARS-CoV-2 infected and/or vaccinated mothers or uninfected/non-vaccinated mothers.
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platform:
GPL21697
9 Samples
Download data: XLSX
Series
Accession:
GSE196802
ID:
200196802
4.

Real-time quantitative PCR analysis of mouse lungs after exposure to early SARS-CoV-2 bearing 614G, Kappa or Delta variant

(Submitter supplied) Age-matched K18-hACE2 transgenic mice were passively transferred with human COVID-19 mRNA post-vaccination (post-vac) sera followed by the lethal challenge with different SARS-CoV-2 viruses via intranasal route, including (1) New York-PV09158/2020 (NY) of lineage B.1.3 bearing 614G, (2) Kappa (B.1.617.1) and (3) Delta (B.1.617.2). Mouse lungs were harvested on 5 days post infection (dpi). Total RNA was extracted using QIAgen RNeasy Plus Mini Kit and was reverse transcribed using the High-Capacity cDNA Reverse Transcription Kit (Thermo Fisher Scientific). more...
Organism:
Mus musculus
Type:
Expression profiling by RT-PCR
Platform:
GPL30599
39 Samples
Download data: TXT
Series
Accession:
GSE193839
ID:
200193839
5.

IL-4 receptor blockade is a global repressor of naïve B cell development and responses in a dupilumab-treated patient

(Submitter supplied) Here, we report a case of atopic dermatitis (AD) in a patient who received biweekly doses of dupilumab, an antibody against the IL-4 receptor α chain (IL-4Rα). Single cell RNA-sequencing showed that naïve B cells expressed the highest levels of IL4R compared to other B cell subpopulations. Compared to controls, the dupilumab-treated patient exhibited diminished percentages of IL4R+IGHD+ naïve B cells and down-regulation of IL4R, FCER2 (CD23), and IGHD. more...
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platform:
GPL18573
4 Samples
Download data: MTX, TSV
Series
Accession:
GSE193096
ID:
200193096
6.

SARS-CoV-2 pseudovirus infection in BMMs

(Submitter supplied) Single-cell transcriptome analysis of SARS-CoV-2 pseudovirus infection in cultured BMMs that are derived from 1-month and 18-month mice
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL24247
2 Samples
Download data: MTX, TSV
Series
Accession:
GSE169599
ID:
200169599
7.

Single Cell Multiomics of Healthy, COVID-19 positive and Recovered Individuals

(Submitter supplied) We performed scRNA sequencing to understand the cellular heterogeneity and immune response landscape behind COVID-19 pathophysiology. We combine this with Ab-Seq, oligo-attached antibody based quantification of cell surface proteins to better understand the cell type and state of the cells. Samples were multiplexed using BD single-cell multiplexing kit (Human) in order to measure these data simultaneously
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing; Other
Platform:
GPL24676
7 Samples
Download data: CSV, TXT
Series
Accession:
GSE201088
ID:
200201088
8.

Modulation of type-I interferon responses in Rhesus Macaque whole blood

(Submitter supplied) RNA-sequencing used to investigate the transcriptome response to Sars-cov-2 in the presence of IFN treatment
Organism:
Macaca mulatta
Type:
Expression profiling by high throughput sequencing
Platform:
GPL27943
60 Samples
Download data: TXT
Series
Accession:
GSE207665
ID:
200207665
9.

Modulation of type-I interferon responses reduces SARS-CoV-2 replication and inflammation in rhesus macaques

(Submitter supplied) Inflammation following SARS-CoV-2 infection is a hallmark of COVID-19 and predictive of morbidity and death. However, the inflammatory pathways contributing to host-defense vs immune-mediated pathology have not been fully elucidated. This duality is clearly seen with type-I interferons (IFN-I) which are critical mediators of innate control of viral infections, but also drive recruitment of inflammatory cells to site of infection, a key feature of severe COVID-19. more...
Organism:
Macaca mulatta
Type:
Expression profiling by high throughput sequencing
Platform:
GPL27943
240 Samples
Download data: CSV, H5
Series
Accession:
GSE205429
ID:
200205429
10.

Pathogenic neutrophilia drives acute respiratory distress syndrome in severe COVID-19 patients

(Submitter supplied) Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and the ensuing COVID-19 pandemic have caused ∼40 million cases and over 648,000 deaths in the United States alone. Troubling disparities in COVID-19-associated mortality emerged early, with nearly 70% of deaths confined to Black/African-American (AA) patients in some areas, yet targeted studies within this demographic are scant. Multi-omics single-cell analyses of immune profiles from airways and matching blood samples of Black/AA patients revealed low viral load, yet pronounced and persistent pulmonary neutrophilia with advanced features of cytokine release syndrome and acute respiratory distress syndrome (ARDS), including exacerbated production of IL-8, IL-1β, IL-6, and CCL3/4 along with elevated levels of neutrophil elastase and myeloperoxidase. more...
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing; Other
Platform:
GPL24676
28 Samples
Download data: CSV, H5, RDS
Series
Accession:
GSE186267
ID:
200186267
11.

Epigenetic clocks are not accelerated in COVID-19 patients

(Submitter supplied) In this study, we used blood samples of nine patients with severe SARS-CoV-2 infection either with or without acute respiratory distress syndrome (ARDS) and analyzed them on the Illumina EPIC methylation microarray.
Organism:
Homo sapiens
Type:
Methylation profiling by genome tiling array
Platform:
GPL21145
9 Samples
Download data: IDAT, TXT
Series
Accession:
GSE161988
ID:
200161988
12.

A TLR7-nanoparticle adjuvant promotes broad immune responses against heterologous strains of Influenza and SARS-CoV-2

(Submitter supplied) Effective vaccines against viruses such as Influenza and SARS-CoV-2 must elicit a diverse repertoire of antibodies against multiple variant virus strains. However, antibody responses to current vaccines often lack cross-reactivity due to immunodominance. Here, we describe the synthesis of a toll-like receptor 7 agonist (TLR7)-nanoparticle adjuvant, TLR7-NP, constructed from TLR7 agonist-initiated ring-opening polymerization of lactide and self-assembly with poly(ethylene glycol)-b-poly(lactic-co-glycolic acid). more...
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platform:
GPL24676
1 Sample
Download data: TSV
Series
Accession:
GSE217918
ID:
200217918
13.

Altered microRNA transcriptome in cultured human airway cells upon infection with SARS-CoV-2

(Submitter supplied) Numerous proteomic and transcriptomic studies have been carried out to better understand the current multi-variant SARS-CoV-2 virus mechanisms of action and effects. However, they are mostly centered on mRNAs and proteins. The effect of the virus on human post-transcriptional regulatory agents such as microRNAs (miRNAs) involved in the regulation of 60% of human gene activity remains poorly explored. more...
Organism:
Homo sapiens
Type:
Non-coding RNA profiling by high throughput sequencing
Platform:
GPL18573
12 Samples
Download data: FA, XLS
Series
Accession:
GSE217863
ID:
200217863
14.

Transcriptomic profiling of peripheral immune cells reveals distinct innate immune signatures associated with disease severity in COVID-19 viremia patients

(Submitter supplied) SARS-CoV-2 is an emerging mosquito-borne pathogen with increasing public health significance. To characterize interconnected immune responses to SARS-CoV-2, we here examined transcriptional signatures of CD4 and CD8 T cells, B cells, NK cells, monocytes, myeloid dendritic cells (mDCs), and plasmacytoid dendritic cells (pDCs) from three individuals with naturally-acquired SARS-CoV-2 infection. Whole transcriptome analysis demonstrated that all seven immune cells among PBMCs were clustered together with disease severity regardless of cell types. more...
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platform:
GPL21697
119 Samples
Download data: CSV
Series
Accession:
GSE216529
ID:
200216529
15.

Sequence and dynamics of SARS-CoV-2 host cell interactions inferred from transcriptome analyses

(Submitter supplied) The worldwide spread of severe acute respiratory syndrome-related coronavirus-2 (SARS- CoV-2) caused an urgent need for an in-depth understanding of virus-host interactions. Here, we dissected the dynamics of virus replication and the host cell transcriptional response to SARS-CoV-2 infection at a systems level by combining time-resolved RNA sequencing with mathematical modeling. We observed an immediate transcriptional activation of inflammatory pathways linked to the anti-viral response followed by increased expression of genes involved in ribosome and mitochondria function, thus hinting at rapid alterations in protein production and cellular energy supply. more...
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platform:
GPL24676
33 Samples
Download data: CSV
Series
Accession:
GSE217504
ID:
200217504
16.

Neutrophil Profiles of Pediatric COVID-19 and Multisystem Inflammatory Syndrome in Children

(Submitter supplied) Multisystem Inflammatory Syndrome in Children (MIS-C) is a delayed-onset, COVID-19-related hyperinflammatory illness characterized by SARS-CoV-2 antigenemia, cytokine storm, and immune dysregulation. In severe COVID-19, neutrophil activation is central to hyperinflammatory complications, yet the role of neutrophils in MIS-C is undefined. Here, we collect blood from 152 children: 31 cases of MIS-C, 43 cases of acute pediatric COVID-19, and 78 pediatric controls. more...
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platform:
GPL18573
48 Samples
Download data: TXT
Series
Accession:
GSE217370
ID:
200217370
17.

Loss of GM-CSF-dependent instruction of alveolar macrophages in COVID-19 provides a rationale for inhaled GM-CSF treatment

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Homo sapiens; Mus musculus; Mus
Type:
Expression profiling by high throughput sequencing; Expression profiling by array
Platforms:
GPL6246 GPL24676
46 Samples
Download data: CEL, H5
Series
Accession:
GSE216705
ID:
200216705
18.

Loss of GM-CSF-dependent instruction of alveolar macrophages in COVID-19 provides a rationale for inhaled GM-CSF treatment (RNA-Seq)

(Submitter supplied) Systemic GM-CSF promotes myelopoiesis and inflammation and GM-CSF blockade is being evaluated as treatment for COVID-19-associated hyperinflammation. Alveolar GM-CSF is however required for monocytes to differentiate into alveolar macrophages (AM) that control alveolar homeostasis and dampen inflammation. By mapping cross-species AM development stages to clinical lung samples, we discovered that COVID-19 is marked by defective GM-CSF-dependent AM instruction and accumulation of proinflammatory macrophages. more...
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platform:
GPL24676
19 Samples
Download data: CSV, H5
Series
Accession:
GSE216704
ID:
200216704
19.

Loss of evolutionary conserved GM-CSF-dependent signature in pulmonary macrophages in COVID-19 provides a rationale for inhaled GM-CSF treatment (microarray)

(Submitter supplied) Alveolar GM-CSF is required for monocytes to differentiate into alveolar macrophages (AM) that control alveolar homeostasis and dampen inflammation. By mapping cross-species AM development stages to clinical lung samples, we discovered that COVID-19 is marked by defective GM-CSF-dependent AM instruction and accumulation of proinflammatory macrophages. In a multi-center, open-label, randomized, controlled trial in 81 non-ventilated COVID-19 patients with respiratory failure, we found that inhalation of rhu-GM-CSF did not improve mean oxygenation parameters compared with standard treatment. more...
Organism:
Mus; Mus musculus
Type:
Expression profiling by array
Platform:
GPL6246
27 Samples
Download data: CEL, TXT
Series
Accession:
GSE216701
ID:
200216701
20.

Effect of AMP-CpG on lymph node immune response in rhesus macaque

(Submitter supplied) Despite the success of currently authorized vaccines for the reduction of severe COVID-19 disease risk, rapidly emerging viral variants continue to drive pandemic waves of infection, resulting in numerous global public health challenges. Progress will depend on future advances in prophylactic vaccine activity, including advancement of candidates capable of generating more potent induction of cross-reactive T cells and durable cross-reactive antibody responses. more...
Organism:
Macaca mulatta
Type:
Expression profiling by array
Platform:
GPL32711
6 Samples
Download data: RCC, XLSX
Series
Accession:
GSE214564
ID:
200214564
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