ClinVar for Gene (Select 7157) - ClinVar - NCBI

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	Variation	Gene (Protein Change)	Type (Consequence)	Condition	Classification, Review status
Select item 3906155	NM_000546.6(TP53):c.994-27_994-24del	TP53	Microsatellite (intron variant)	Hereditary cancer-predisposing syndrome	GUncertain significance
Select item 3906024	NM_000546.6(TP53):c.407A>T (p.Gln136Leu)	TP53 (Q136L +2 more)	Single nucleotide variant (missense variant +2 more)	not provided	GUncertain significance
Select item 3905024	NC_000017.11:g.7666193C>T	TP53	Single nucleotide variant	not provided	GLikely benign
Select item 3903838	NM_000546.6(TP53):c.783-1G>C	TP53	Single nucleotide variant (splice acceptor variant)	Li-Fraumeni syndrome 1	GLikely pathogenic
Select item 3898631	NM_000546.6(TP53):c.247G>T (p.Ala83Ser)	TP53 (A44S +1 more)	Single nucleotide variant (missense variant +1 more)	not provided	GUncertain significance
Select item 3895777	NC_000017.10:g.(7574034_7576852)_(7576927_7577018)dup	TP53	Duplication	Li-Fraumeni syndrome	GLikely pathogenic
Select item 3895669	NC_000017.10:g.(?_7571738)_(7579941_7590694)dup	TP53, WRAP53	Duplication	not specified	GUncertain significance
Select item 3894270	NM_000546.6(TP53):c.167A>G (p.Glu56Gly)	TP53 (E17G +1 more)	Single nucleotide variant (missense variant +1 more)	Hereditary cancer-predisposing syndrome	GUncertain significance
Select item 3893901	NM_000546.6(TP53):c.383_388dup (p.Ala129_Leu130insProAla)	TP53	Duplication (non-coding transcript variant +1 more)	Hereditary cancer-predisposing syndrome	GUncertain significance
Select item 3893866	NM_000546.6(TP53):c.858A>C (p.Glu286Asp)	TP53 (E127D +3 more)	Single nucleotide variant (missense variant +1 more)	Hereditary cancer-predisposing syndrome	GUncertain significance
Select item 3893669	NM_000546.6(TP53):c.586del (p.Arg196fs)	TP53 (R157fs +3 more)	Deletion (frameshift variant)	Hereditary cancer-predisposing syndrome	GLikely pathogenic
Select item 3893309	NM_000546.6(TP53):c.404G>C (p.Cys135Ser)	TP53 (C135S +2 more)	Single nucleotide variant (missense variant +2 more)	not provided	GLikely pathogenic
Select item 3893199	NM_000546.6(TP53):c.962A>C (p.Lys321Thr)	TP53 (K162T +3 more)	Single nucleotide variant (missense variant +1 more)	Hereditary cancer-predisposing syndrome	GUncertain significance
Select item 3893198	NM_000546.6(TP53):c.827C>T (p.Ala276Val)	TP53 (A117V +3 more)	Single nucleotide variant (missense variant +1 more)	Hereditary cancer-predisposing syndrome	GUncertain significance
Select item 3892955	NC_000017.10:g.7578466_7590809del	TP53, WRAP53	Deletion	Adrenocortical carcinoma, hereditary +10 more	GPathogenic
Select item 3809691	NM_000546.6(TP53):c.34C>T (p.Pro12Ser)	TP53 (P12S)	Single nucleotide variant (missense variant +2 more)	Hereditary cancer-predisposing syndrome	GUncertain significance
Select item 3809690	NM_000546.6(TP53):c.436_456del (p.Trp146_Pro152del)	TP53	Deletion (inframe_deletion +2 more)	Hereditary cancer-predisposing syndrome	GLikely pathogenic
Select item 3809689	NM_000546.6(TP53):c.919+3A>T	TP53	Single nucleotide variant (intron variant)	Hereditary cancer-predisposing syndrome	GUncertain significance
Select item 3809688	NM_000546.6(TP53):c.424C>G (p.Pro142Ala)	TP53 (P103A +2 more)	Single nucleotide variant (missense variant +2 more)	Hereditary cancer-predisposing syndrome	GUncertain significance
Select item 3809687	NM_000546.6(TP53):c.621T>G (p.Asp207Glu)	TP53 (D207E +3 more)	Single nucleotide variant (missense variant)	Hereditary cancer-predisposing syndrome	GLikely benign
Select item 3809686	NM_000546.6(TP53):c.763_766delinsCT (p.Ile255fs)	TP53 (I96fs +3 more)	Indel (frameshift variant +1 more)	Hereditary cancer-predisposing syndrome	GPathogenic
Select item 3809685	NM_000546.6(TP53):c.436_457del (p.Trp146fs)	TP53 (W107fs +2 more)	Deletion (frameshift variant +2 more)	Hereditary cancer-predisposing syndrome	GPathogenic
Select item 3809683	NM_000546.6(TP53):c.185A>G (p.Glu62Gly)	TP53 (E23G +1 more)	Single nucleotide variant (missense variant +1 more)	Hereditary cancer-predisposing syndrome	GLikely benign
Select item 3809682	NM_000546.6(TP53):c.353del (p.Thr118fs)	TP53 (T118fs +1 more)	Deletion (frameshift variant +1 more)	Hereditary cancer-predisposing syndrome	GPathogenic
Select item 3809681	NM_000546.6(TP53):c.763_767delinsCTG (p.Ile255fs)	TP53 (I123fs +3 more)	Indel (frameshift variant +1 more)	Hereditary cancer-predisposing syndrome	GPathogenic
Select item 3809680	NM_000546.6(TP53):c.559_559+6del	TP53	Deletion (splice donor variant)	Hereditary cancer-predisposing syndrome	GLikely pathogenic
Select item 3809679	NM_000546.6(TP53):c.1124_1127del (p.Gln375fs)	TP53 (Q336fs +3 more)	Deletion (frameshift variant +2 more)	Hereditary cancer-predisposing syndrome	GUncertain significance
Select item 3809678	NM_000546.6(TP53):c.457_460dup (p.Gly154fs)	TP53 (G22fs +2 more)	Microsatellite (frameshift variant +2 more)	Hereditary cancer-predisposing syndrome	GPathogenic
Select item 3809677	NM_000546.6(TP53):c.215_216delinsGA (p.Pro72Arg)	TP53 (P33R +1 more)	Indel (missense variant +1 more)	Hereditary cancer-predisposing syndrome	GBenign
Select item 3809676	NM_000546.6(TP53):c.305_307del (p.Thr102_Tyr103delinsAsn)	TP53	Deletion (inframe_indel +1 more)	Hereditary cancer-predisposing syndrome	GUncertain significance
Select item 3809675	NM_000546.6(TP53):c.1123del (p.Gln375fs)	TP53 (Q375fs +3 more)	Deletion (frameshift variant +2 more)	Hereditary cancer-predisposing syndrome	GUncertain significance
Select item 3809674	NM_000546.6(TP53):c.372C>G (p.Cys124Trp)	TP53 (C124W +1 more)	Single nucleotide variant (missense variant +1 more)	Hereditary cancer-predisposing syndrome	GLikely benign
Select item 3809673	NM_000546.6(TP53):c.496T>A (p.Ser166Thr)	TP53 (S127T +3 more)	Single nucleotide variant (missense variant +1 more)	Hereditary cancer-predisposing syndrome	GLikely benign
Select item 3809672	NM_000546.6(TP53):c.546C>A (p.Cys182Ter)	TP53 (C50* +3 more)	Single nucleotide variant (nonsense +1 more)	Hereditary cancer-predisposing syndrome	GPathogenic
Select item 3809668	NM_000546.6(TP53):c.684C>T (p.Asp228=)	TP53	Single nucleotide variant (synonymous variant +1 more)	Hereditary cancer-predisposing syndrome	GLikely benign
Select item 3809665	NM_000546.6(TP53):c.588A>G (p.Arg196=)	TP53	Single nucleotide variant (synonymous variant)	Hereditary cancer-predisposing syndrome	GLikely benign
Select item 3780952	NM_000546.6(TP53):c.*8C>T	TP53	Single nucleotide variant (3 prime UTR variant +1 more)	Familial pancreatic carcinoma	GUncertain significance
Select item 3780735	NM_000546.6(TP53):c.673-39G>A	TP53	Single nucleotide variant (intron variant)	Li-Fraumeni syndrome	GLikely pathogenic
Select item 3780734	NM_000546.6(TP53):c.715_720del (p.Asn239_Ser240del)	TP53	Deletion (non-coding transcript variant)	Familial cancer of breast +1 more	GUncertain significance
Select item 3780733	NM_000546.6(TP53):c.672+13A>C	TP53	Single nucleotide variant (intron variant)	Li-Fraumeni syndrome	GLikely benign
Select item 3780731	NM_000546.6(TP53):c.359A>C (p.Lys120Thr)	TP53 (K120T +1 more)	Single nucleotide variant (missense variant +1 more)	Li-Fraumeni syndrome 1	GUncertain significance
Select item 3780730	NM_000546.6(TP53):c.1007A>G (p.Glu336Gly)	TP53 (E177G +3 more)	Single nucleotide variant (missense variant +2 more)	Familial cancer of breast +1 more	GUncertain significance
Select item 3774484	NM_000546.6(TP53):c.861del (p.Asn288fs)	TP53 (N129fs +3 more)	Deletion (frameshift variant +1 more)	Li-Fraumeni syndrome 1	GPathogenic
Select item 3773928	NM_000546.6(TP53):c.-26G>A	TP53	Single nucleotide variant (5 prime UTR variant +2 more)	not provided	GUncertain significance
Select item 3773528	NM_000546.6(TP53):c.1054_1055del (p.Asp352fs)	TP53 (D193fs +3 more)	Deletion (frameshift variant +2 more)	Li-Fraumeni syndrome 1	GLikely pathogenic
Select item 3773522	NM_000546.6(TP53):c.783-4_803delinsC	TP53	Indel (splice acceptor variant)	Li-Fraumeni syndrome 1	GLikely pathogenic
Select item 3766516	NM_000546.6(TP53):c.441_442insCTTC (p.Asp148fs)	TP53 (D109fs +2 more)	Insertion (frameshift variant +2 more)	not provided	GPathogenic
Select item 3765176	NM_000546.6(TP53):c.74+39A>C	TP53	Single nucleotide variant (5 prime UTR variant +1 more)	not specified	GLikely benign
Select item 3765175	NM_000546.6(TP53):c.75-50T>C	TP53	Single nucleotide variant (5 prime UTR variant +1 more)	not specified	GLikely benign
Select item 3765174	NM_000546.6(TP53):c.375+26C>A	TP53	Single nucleotide variant (intron variant)	not specified	GLikely benign
Select item 3765172	NM_000546.6(TP53):c.559+32C>A	TP53	Single nucleotide variant (intron variant)	not specified	GLikely benign
Select item 3765171	NM_000546.6(TP53):c.672+34G>A	TP53	Single nucleotide variant (intron variant)	not specified	GLikely benign
Select item 3765170	NM_000546.6(TP53):c.673-33C>T	TP53	Single nucleotide variant (intron variant)	not specified	GLikely benign
Select item 3765169	NM_000546.6(TP53):c.673-29C>T	TP53	Single nucleotide variant (intron variant)	not specified	GLikely benign
Select item 3765168	NM_000546.6(TP53):c.919+32G>A	TP53	Single nucleotide variant (intron variant)	not specified	GLikely benign
Select item 3765167	NM_000546.6(TP53):c.1101-43C>T	TP53	Single nucleotide variant (intron variant)	not specified	GLikely benign
Select item 3765166	NM_000546.6(TP53):c.1101-26C>T	TP53	Single nucleotide variant (intron variant)	not specified	GLikely benign
Select item 3764957	NM_000546.6(TP53):c.311_313del (p.Gln104_Gly105delinsArg)	TP53	Deletion (inframe_indel +1 more)	Neoplasm	OUncertain significance
Select item 3764955	NM_000546.6(TP53):c.450_454dup (p.Pro152fs)	TP53 (P113fs +2 more)	Duplication (frameshift variant +2 more)	Neoplasm	OLikely oncogenic
Select item 3764954	NM_000546.6(TP53):c.510_517dup (p.Val173fs)	TP53 (V134fs +3 more)	Duplication (frameshift variant +1 more)	Neoplasm	OLikely oncogenic
Select item 3764952	NM_000546.6(TP53):c.637_644del (p.Arg213fs)	TP53 (R174fs +3 more)	Deletion (frameshift variant)	Neoplasm	OLikely oncogenic
Select item 3764950	NM_000546.6(TP53):c.712_714dup (p.Cys238_Asn239insCys)	TP53	Duplication (non-coding transcript variant)	Neoplasm	OUncertain significance
Select item 3764949	NM_000546.6(TP53):c.757_779del (p.Thr253fs)	TP53 (T121fs +3 more)	Deletion (frameshift variant +1 more)	Neoplasm	OLikely oncogenic
Select item 3764948	NM_000546.6(TP53):c.851_852del (p.Thr284fs)	TP53 (T125fs +3 more)	Microsatellite (frameshift variant +1 more)	Neoplasm	OLikely oncogenic
Select item 3764945	NM_000546.6(TP53):c.1001G>T (p.Gly334Val)	TP53 (G175V +3 more)	Single nucleotide variant (missense variant +2 more)	Neoplasm	OLikely oncogenic
Select item 3764944	NM_000546.6(TP53):c.1173del (p.Ser392fs)	TP53 (S233fs +3 more)	Deletion (frameshift variant +2 more)	Neoplasm	OUncertain significance
Select item 3764816	NM_000546.6(TP53):c.327_328delinsA (p.Phe109fs)	TP53 (F109fs +1 more)	Indel (frameshift variant +1 more)	Neoplasm	OLikely oncogenic
Select item 3764815	NM_000546.6(TP53):c.453_474delinsGGGT (p.Pro152_Arg158delinsGly)	TP53	Indel (inframe_indel +2 more)	Neoplasm	OUncertain significance
Select item 3764814	NM_000546.6(TP53):c.832_833delinsGT (p.Pro278Val)	TP53 (P119V +3 more)	Indel (missense variant +1 more)	Neoplasm	OLikely oncogenic
Select item 3764560	NM_000546.6(TP53):c.646_663del (p.Val216_Glu221del)	TP53	Deletion	TP53-related disorder	GLikely pathogenic
Select item 3729757	NM_000546.6(TP53):c.375+10_375+12del	TP53	Deletion (intron variant)	Li-Fraumeni syndrome	GLikely benign
Select item 3729480	NM_000546.6(TP53):c.654_655insT (p.Pro219fs)	TP53 (P60fs +3 more)	Insertion (frameshift variant)	Li-Fraumeni syndrome	GPathogenic
Select item 3729413	NM_000546.6(TP53):c.783-7_794del	TP53	Deletion (splice acceptor variant)	Li-Fraumeni syndrome	GPathogenic
Select item 3729356	NM_000546.6(TP53):c.919+21_929dup	TP53	Duplication (splice acceptor variant)	Li-Fraumeni syndrome	GLikely benign
Select item 3728507	NM_000546.6(TP53):c.215_216inv (p.Pro72Arg)	TP53 (P33R +1 more)	Inversion (missense variant +1 more)	Li-Fraumeni syndrome	GLikely benign
Select item 3727834	NM_000546.6(TP53):c.979_993+7del	TP53	Deletion (splice donor variant)	Li-Fraumeni syndrome	GLikely pathogenic
Select item 3727282	NM_000546.6(TP53):c.97-20C>G	TP53	Single nucleotide variant (intron variant)	Li-Fraumeni syndrome	GLikely benign
Select item 3725919	NM_000546.6(TP53):c.96+11G>C	TP53	Single nucleotide variant (intron variant)	Li-Fraumeni syndrome	GLikely benign
Select item 3725755	NM_000546.6(TP53):c.920-20T>A	TP53	Single nucleotide variant (intron variant)	Li-Fraumeni syndrome	GLikely benign
Select item 3725718	NM_000546.6(TP53):c.239del (p.Pro80fs)	TP53 (P41fs +1 more)	Deletion (frameshift variant +1 more)	Li-Fraumeni syndrome	GPathogenic
Select item 3724944	NM_000546.6(TP53):c.848_851del (p.Arg283fs)	TP53 (R244fs +3 more)	Deletion (frameshift variant +1 more)	Li-Fraumeni syndrome	GPathogenic
Select item 3724593	NM_000546.6(TP53):c.495_498dup (p.Gln167fs)	TP53 (Q35fs +3 more)	Duplication (frameshift variant +1 more)	Li-Fraumeni syndrome	GPathogenic
Select item 3724581	NM_000546.6(TP53):c.993+16A>G	TP53	Single nucleotide variant (intron variant)	Li-Fraumeni syndrome	GLikely benign
Select item 3724149	NM_000546.6(TP53):c.559+12G>T	TP53	Single nucleotide variant (intron variant)	Li-Fraumeni syndrome	GLikely benign
Select item 3723500	NM_000546.6(TP53):c.994-7G>A	TP53	Single nucleotide variant (intron variant)	Li-Fraumeni syndrome	GLikely benign
Select item 3723298	NM_000546.6(TP53):c.508_510del (p.Thr170del)	TP53 (T170del +3 more)	Deletion (non-coding transcript variant)	Li-Fraumeni syndrome	GUncertain significance
Select item 3722647	NM_000546.6(TP53):c.419_427del (p.Thr140_Val143delinsMet)	TP53	Deletion (inframe_indel +2 more)	Li-Fraumeni syndrome	GPathogenic
Select item 3722426	NM_000546.6(TP53):c.1001_1006dup (p.Arg335_Glu336insGlyArg)	TP53	Duplication (3 prime UTR variant +1 more)	Li-Fraumeni syndrome	GLikely pathogenic
Select item 3721766	NM_000546.6(TP53):c.993+18C>G	TP53	Single nucleotide variant (intron variant)	Li-Fraumeni syndrome	GLikely benign
Select item 3719560	NM_000546.6(TP53):c.783-19C>G	TP53	Single nucleotide variant (intron variant)	Li-Fraumeni syndrome	GLikely benign
Select item 3717011	NM_000546.6(TP53):c.846del (p.Arg283fs)	TP53 (R151fs +3 more)	Deletion (frameshift variant +1 more)	Li-Fraumeni syndrome	GPathogenic
Select item 3708635	NM_000546.6(TP53):c.781A>C (p.Ser261Arg)	TP53 (S222R +3 more)	Single nucleotide variant (missense variant +1 more)	Li-Fraumeni syndrome	GUncertain significance
Select item 3706400	NM_000546.6(TP53):c.190C>A (p.Pro64Thr)	TP53 (P25T +1 more)	Single nucleotide variant (missense variant +1 more)	Li-Fraumeni syndrome	GUncertain significance
Select item 3701723	NM_000546.6(TP53):c.74+15T>G	TP53	Single nucleotide variant (5 prime UTR variant +1 more)	Li-Fraumeni syndrome	GLikely benign
Select item 3700441	NM_000546.6(TP53):c.560-14C>G	TP53	Single nucleotide variant (intron variant)	Li-Fraumeni syndrome	GUncertain significance
Select item 3699453	NM_000546.6(TP53):c.528C>T (p.Cys176=)	TP53	Single nucleotide variant (synonymous variant +1 more)	Li-Fraumeni syndrome	GLikely benign
Select item 3696704	NM_000546.6(TP53):c.222C>G (p.Ala74=)	TP53	Single nucleotide variant (synonymous variant +1 more)	Li-Fraumeni syndrome	GLikely benign
Select item 3679814	NM_000546.6(TP53):c.375+8G>A	TP53	Single nucleotide variant (intron variant)	Li-Fraumeni syndrome	GLikely benign
Select item 3679774	NM_000546.6(TP53):c.1034A>G (p.Asn345Ser)	TP53 (N213S +3 more)	Single nucleotide variant (missense variant +2 more)	Li-Fraumeni syndrome	GUncertain significance
Select item 3678514	NM_000546.6(TP53):c.74+15T>C	TP53	Single nucleotide variant (5 prime UTR variant +1 more)	Li-Fraumeni syndrome	GLikely benign

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