NM_000769.1(CYP2C19):c.-806C>T AND Clopidogrel response

Germline classification:: drug response (1 submission)
Review status:: (0/4) 0 stars out of maximum of 4 stars
no assertion criteria provided

Somatic classification of clinical impact:: None
Review status:: (0/4) 0 stars out of maximum of 4 stars
no assertion criteria provided

Somatic classification of oncogenicity:: None
Review status:: (0/4) 0 stars out of maximum of 4 stars
no assertion criteria provided

Record status:: current
Accession:: RCV004813048.2

Allele description [Variation Report for NM_000769.1(CYP2C19):c.-806C>T]

NM_000769.1(CYP2C19):c.-806C>T

Genes:

CYP2C19:cytochrome P450 family 2 subfamily C member 19 [Gene - OMIM - HGNC]
LOC110599570:CYP2C19 promoter [Gene]

Variant type:

single nucleotide variant

Cytogenetic location:

10q23.33

Genomic location:

Preferred name:

NM_000769.1(CYP2C19):c.-806C>T

Other names:

CYP2C19*17

HGVS:

NC_000010.11:g.94761900C>T
NG_008384.3:g.4220C>T
NG_055436.1:g.1260C>T
NM_000769.4:c.-806C>TMANE SELECT
NC_000010.10:g.96521657C>T
NM_000769.1:c.-806C>T
NM_000769.2:c.-806C>T

Links:

Genetic Testing Registry (GTR): GTR000569929; dbSNP: rs12248560

Molecular consequence:

NM_000769.4:c.-806C>T - upstream transcript variant - [Sequence Ontology: SO:0001986]

Condition(s)

Name:: Clopidogrel response
Synonyms:: Plavix response
Identifiers:: MedGen: CN077970

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Submission Accession	Submitter	Review Status (Assertion method)	Clinical Significance (Last evaluated)	Origin	Method	Citations
SCV005438653	Faculty of Pharmacy, Damascus University	no assertion criteria provided	drug response Condition: Clopidogrel Response Drug reported used for: Coronary Artery Disease	germline	research

Submission Accession

Submitter

Review Status
(Assertion method)

Clinical Significance
(Last evaluated)

Origin

Method

Citations

SCV005438653

Faculty of Pharmacy, Damascus University

no assertion criteria provided

drug response
Condition: Clopidogrel Response
Drug reported used for: Coronary Artery Disease

germline

research

Help

Summary from all submissions

Ethnicity	Origin	Affected	Individuals	Families	Chromosomes tested	Number Tested	Family history	Method
not provided	germline	yes	not provided	not provided	not provided	not provided	not provided	research

Details of each submission

From Faculty of Pharmacy, Damascus University, SCV005438653.2

#	Ethnicity	Individuals	Chromosomes Tested	Family History	Method	Citations
1	not provided	not provided	not provided	not provided	research	not provided

Description

rs12248560 is a SNP in the CYP2C19 gene and is linked to increased clopidogrel metabolic activation. rs12248560 is associated with increased enzyme activity of CYP2C19 and higher concentration of clopidogrel active metabolite.

#	Sample				Method		Observation
#	Origin	Affected	Number tested	Tissue	Purpose	Method	Individuals	Allele frequency	Families	Co-occurrences
1	germline	yes	not provided	not provided	not provided		not provided	not provided	not provided	not provided

Last Updated: Apr 25, 2026

ClinVar

Relating variation to medicine