NM_000245.4(MET):c.2595T>C (p.Ile865=) AND Renal cell carcinoma

Germline classification:: Likely benign (1 submission)
Last evaluated:: Apr 30, 2025
Review status:: 1 star out of maximum of 4 stars
criteria provided, single submitter

Somatic classification of clinical impact:: None
Review status:: (0/4) 0 stars out of maximum of 4 stars
no assertion criteria provided

Somatic classification of oncogenicity:: None
Review status:: (0/4) 0 stars out of maximum of 4 stars
no assertion criteria provided

Record status:: current
Accession:: RCV001417667.9

Allele description [Variation Report for NM_000245.4(MET):c.2595T>C (p.Ile865=)]

NM_000245.4(MET):c.2595T>C (p.Ile865=)

Gene:

MET:MET proto-oncogene, receptor tyrosine kinase [Gene - OMIM - HGNC]

Variant type:

single nucleotide variant

Cytogenetic location:

7q31.2

Genomic location:

Preferred name:

NM_000245.4(MET):c.2595T>C (p.Ile865=)

HGVS:

NC_000007.14:g.116769656T>C
NG_008996.1:g.102252T>C
NM_000245.4:c.2595T>CMANE SELECT
NM_001127500.3:c.2649T>C
NM_001324401.3:c.2595T>C
NM_001324402.2:c.1305T>C
NP_000236.2:p.Ile865=
NP_001120972.1:p.Ile883=
NP_001311330.1:p.Ile865=
NP_001311331.1:p.Ile435=
LRG_662t1:c.2649T>C
LRG_662:g.102252T>C
NC_000007.13:g.116409710T>C
NM_001127500.1:c.2649T>C

Links:

dbSNP: rs2116982595

Molecular consequence:

NM_000245.4:c.2595T>C - synonymous variant - [Sequence Ontology: SO:0001819]
NM_001127500.3:c.2649T>C - synonymous variant - [Sequence Ontology: SO:0001819]
NM_001324401.3:c.2595T>C - synonymous variant - [Sequence Ontology: SO:0001819]
NM_001324402.2:c.1305T>C - synonymous variant - [Sequence Ontology: SO:0001819]

Condition(s)

Name:: Renal cell carcinoma
Identifiers:: MONDO: MONDO:0005086; MeSH: D002292; MedGen: C0007134; Human Phenotype Ontology: HP:0005584

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Submission Accession	Submitter	Review Status (Assertion method)	Clinical Significance (Last evaluated)	Origin	Method	Citations
SCV001619872	Labcorp Genetics (formerly Invitae), Labcorp	criteria provided, single submitter (Invitae Variant Classification Sherloc (09022015))	Likely benign (Apr 30, 2025)	germline	clinical testing	PubMed (1) [See all records that cite this PMID]

Submission Accession

Submitter

Review Status
(Assertion method)

Clinical Significance
(Last evaluated)

Origin

Method

Citations

SCV001619872

Labcorp Genetics (formerly Invitae), Labcorp

criteria provided, single submitter

(Invitae Variant Classification Sherloc (09022015))

Likely benign
(Apr 30, 2025)

germline

clinical testing

PubMed (1)
[See all records that cite this PMID]

Help

Summary from all submissions

Ethnicity	Origin	Affected	Individuals	Families	Chromosomes tested	Number Tested	Family history	Method
not provided	germline	unknown	not provided	not provided	not provided	not provided	not provided	clinical testing

Citations

PubMed

Sherloc: a comprehensive refinement of the ACMG-AMP variant classification criteria.

Nykamp K, Anderson M, Powers M, Garcia J, Herrera B, Ho YY, Kobayashi Y, Patil N, Thusberg J, Westbrook M; Invitae Clinical Genomics Group, Topper S.

Genet Med. 2017 Oct;19(10):1105-1117. doi: 10.1038/gim.2017.37. Epub 2017 May 11. Erratum in: Genet Med. 2020 Jan;22(1):240. doi: 10.1038/s41436-019-0624-9..

PubMed [citation]

PMID:: 28492532
PMCID:: PMC5632818

Details of each submission

From Labcorp Genetics (formerly Invitae), Labcorp, SCV001619872.6

#	Ethnicity	Individuals	Chromosomes Tested	Family History	Method	Citations
1	not provided	not provided	not provided	not provided	clinical testing	PubMed (1)

#	Sample				Method		Observation
#	Origin	Affected	Number tested	Tissue	Purpose	Method	Individuals	Allele frequency	Families	Co-occurrences
1	germline	unknown	not provided	not provided	not provided		not provided	not provided	not provided	not provided

Last Updated: Feb 15, 2026

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