NM_052968.4(APOA5):c.-644C>T AND simvastatin response - Efficacy

Clinical significance:drug response (Last evaluated: May 14, 2018)

Review status:3 stars out of maximum of 4 stars

reviewed by expert panel

Based on:
1 submission [Details]
Record status:
current
Accession:
RCV000660845.1

Allele description [Variation Report for NM_052968.4(APOA5):c.-644C>T]

NM_052968.4(APOA5):c.-644C>T

Gene:
APOA5:apolipoprotein A5 [Gene - OMIM - HGNC]
Variant type:
single nucleotide variant
Cytogenetic location:
11q23.3
Genomic location:
Preferred name:
NM_052968.4(APOA5):c.-644C>T
HGVS:
  • NC_000011.10:g.116792991G>A
  • NG_015894.1:g.4430C>T
  • NM_052968.4:c.-644C>T
  • NC_000011.9:g.116663707G>A
Links:
dbSNP: rs662799
NCBI 1000 Genomes Browser:
rs662799

Condition(s)

Name:
simvastatin response - Efficacy
Identifiers:
MedGen: CN236582

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Assertion and evidence details

Submission AccessionSubmitterReview Status
(Assertion method)
Clinical Significance
(Last evaluated)
OriginMethodCitations
SCV000783084PharmGKBreviewed by expert panel
drug response
(May 14, 2018)
Condition: simvastatin response - Efficacy
Drug reported used for: Hyperlipidemias
germlinecuration

PubMed (3)
[See all records that cite these PMIDs]

Citation Link

Description

Drug is not necessarily used to treat response condition

SCV000783084

Summary from all submissions

EthnicityOriginAffectedIndividualsFamiliesChromosomes testedNumber TestedFamily historyMethod
not providedgermlineyesnot providednot providednot providednot providednot providedcuration

Citations

PubMed

Impact of apolipoprotein A5 variants on statin treatment efficacy.

Hubacek JA, Adamkova V, Prusikova M, Snejdrlova M, Hirschfeldova K, Lanska V, Ceska R, Vrablik M.

Pharmacogenomics. 2009 Jun;10(6):945-50. doi: 10.2217/pgs.09.17.

PubMed [citation]
PMID:
19530961

Influence of APOA5 Locus on the Treatment Efficacy of Three Statins: Evidence From a Randomized Pilot Study in Chinese Subjects.

Hua S, Ma C, Zhang J, Li J, Wu W, Xu N, Luo G, Zhao J.

Front Pharmacol. 2018;9:352. doi: 10.3389/fphar.2018.00352.

PubMed [citation]
PMID:
29695967
PMCID:
PMC5904201
See all PubMed Citations (3)

Details of each submission

From PharmGKB, SCV000783084.1

#EthnicityIndividualsChromosomes TestedFamily HistoryMethodCitations
1not providednot providednot providednot providedcuration PubMed (3)

Description

PharmGKB Level of Evidence 2B: Annotation for a variant-drug combination with moderate evidence of an association. The association must be replicated but there may be some studies that do not show statistical significance, and/or the effect size may be small.

#SampleMethodObservation
OriginAffectedNumber testedTissuePurposeMethodIndividualsAllele frequencyFamiliesCo-occurrences
1germlineyesnot providednot providednot providednot providednot providednot providednot provided

Last Updated: Mar 30, 2019

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