ClinVar

Description

Variant summary: RAD51D c.137C>G (p.Ser46Cys) results in a non-conservative amino acid change located in the RAD51D, N-terminal domain (IPR048943) of the encoded protein sequence. Algorithms developed to predict the effect of missense changes on protein structure and function are either unavailable or do not agree on the potential impact of this missense change. The variant allele was found at a frequency of 7.6e-05 in 251312 control chromosomes. This frequency is not significantly higher than estimated for disease-causing variants in RAD51D, allowing no conclusion about variant significance. c.137C>G has been observed in individuals affected with Breast, Ovarian and Colorectal Cancer without clear evidence for causality (Alenezi_2022, Kraus_2017, Wickramanayake_2012, Loveday_2011, Weren_2015, Velazquez_2020, Guindalini_2022, de Oliveira_2022). These report(s) do not provide unequivocal conclusions about association of the variant with Hereditary Breast And Ovarian Cancer Syndrome. Co-occurrences with other pathogenic variant(s) have been reported (MSH2 c.2459-1G>C), providing supporting evidence for a benign role. At least one publication reports experimental evidence evaluating an impact on protein function and the data suggests impaired homologous recombination functionality (Alenezi_2022). The following publications have been ascertained in the context of this evaluation (PMID: 35565380, 33630411, 35264596, 27616075, 21822267, 32522261, 25938944, 22986143, 35534704). ClinVar contains an entry for this variant (Variation ID: 127882). Based on the evidence outlined above, the variant was classified as uncertain significance.