NM_000959.3(PTGFR):c.-562T>C AND latanoprost response - Efficacy

Clinical significance:drug response (Last evaluated: Jan 21, 2015)

Review status:3 stars out of maximum of 4 stars

reviewed by expert panel

Based on:
1 submission [Details]
Record status:
current
Accession:
RCV000211367.1

Allele description [Variation Report for NM_000959.3(PTGFR):c.-562T>C]

NM_000959.3(PTGFR):c.-562T>C

Gene:
PTGFR:prostaglandin F receptor [Gene - OMIM - HGNC]
Variant type:
single nucleotide variant
Cytogenetic location:
1p31.1
Genomic location:
Preferred name:
NM_000959.3(PTGFR):c.-562T>C
HGVS:
  • NC_000001.11:g.78490747T>C
  • NG_052997.1:g.4774T>C
  • NM_000959.3:c.-562T>C
  • NC_000001.10:g.78956432T>C
Links:
PharmGKB Clinical Annotation: 1444667668; dbSNP: rs3753380
NCBI 1000 Genomes Browser:
rs3753380
Molecular consequence:
  • NM_000959.3:c.-562T>C - 2KB upstream variant - [Sequence Ontology: SO:0001636]

Condition(s)

Name:
latanoprost response - Efficacy
Identifiers:
MedGen: CN236563

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Assertion and evidence details

Submission AccessionSubmitterReview Status
(Assertion method)
Clinical Significance
(Last evaluated)
OriginMethodCitations
SCV000268301PharmGKBreviewed by expert panel
drug response
(Jan 21, 2015)
Condition: latanoprost response - Efficacy
Drug reported used for: Glaucoma, Open-Angle
germlinecuration

PubMed (3)
[See all records that cite these PMIDs]

Citation Link

Description

Drug is not necessarily used to treat response condition

SCV000268301

Summary from all submissions

EthnicityOriginAffectedIndividualsFamiliesChromosomes testedNumber TestedFamily historyMethod
not providedgermlineyesnot providednot providednot providednot providednot providedcuration

Citations

PubMed

Association between genetic polymorphisms of the prostaglandin F2alpha receptor gene and response to latanoprost.

Sakurai M, Higashide T, Takahashi M, Sugiyama K.

Ophthalmology. 2007 Jun;114(6):1039-45. Epub 2007 Apr 30. Erratum in: Ophthalmology. 2007 Nov;114(11):2012.

PubMed [citation]
PMID:
17467803

Influence of PTGS1, PTGFR, and MRP4 genetic variants on intraocular pressure response to latanoprost in Chinese primary open-angle glaucoma patients.

Gao LC, Wang D, Liu FQ, Huang ZY, Huang HG, Wang GH, Chen X, Shi QZ, Hong L, Wu LP, Tang J.

Eur J Clin Pharmacol. 2015 Jan;71(1):43-50. doi: 10.1007/s00228-014-1769-8. Epub 2014 Oct 23.

PubMed [citation]
PMID:
25339146
See all PubMed Citations (3)

Details of each submission

From PharmGKB, SCV000268301.3

#EthnicityIndividualsChromosomes TestedFamily HistoryMethodCitations
1not providednot providednot providednot providedcuration PubMed (3)

Description

PharmGKB Level of Evidence 2B: Annotation for a variant-drug combination with moderate evidence of an association. The association must be replicated but there may be some studies that do not show statistical significance, and/or the effect size may be small.

#SampleMethodObservation
OriginAffectedNumber testedTissuePurposeMethodIndividualsAllele frequencyFamiliesCo-occurrences
1germlineyesnot providednot providednot providednot providednot providednot providednot provided

Last Updated: Mar 30, 2019

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