NM_000621.4(HTR2A):c.614-2211T>C AND Selective serotonin reuptake inhibitors response - Efficacy

Clinical significance:drug response (Last evaluated: Oct 15, 2015)

Review status:3 stars out of maximum of 4 stars

reviewed by expert panel

Based on:
1 submission [Details]
Record status:
current
Accession:
RCV000211197.1

Allele description [Variation Report for NM_000621.4(HTR2A):c.614-2211T>C]

NM_000621.4(HTR2A):c.614-2211T>C

Gene:
HTR2A:5-hydroxytryptamine receptor 2A [Gene - OMIM - HGNC]
Variant type:
single nucleotide variant
Cytogenetic location:
13q14.2
Genomic location:
Preferred name:
NM_000621.4(HTR2A):c.614-2211T>C
HGVS:
  • NC_000013.11:g.46837850A>G
  • NG_013011.1:g.64185T>C
  • NM_000621.4:c.614-2211T>C
  • LRG_1008t1:c.614-2211T>C
  • LRG_1008:g.64185T>C
  • NC_000013.10:g.47411985A>G
Nucleotide change:
IVS2, A-G
Links:
PharmGKB Clinical Annotation: 637880425; OMIM: 182135.0003; dbSNP: rs7997012
NCBI 1000 Genomes Browser:
rs7997012
Molecular consequence:
  • NM_000621.4:c.614-2211T>C - intron variant - [Sequence Ontology: SO:0001627]

Condition(s)

Name:
Selective serotonin reuptake inhibitors response - Efficacy
Identifiers:
MedGen: CN236561

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Assertion and evidence details

Submission AccessionSubmitterReview Status
(Assertion method)
Clinical Significance
(Last evaluated)
OriginMethodCitations
SCV000268408PharmGKBreviewed by expert panel
drug response
(Oct 15, 2015)
Condition: Selective serotonin reuptake inhibitors response - Efficacy
Drug reported used for: Depression
germlinecuration

PubMed (10)
[See all records that cite these PMIDs]

Citation Link

Description

Drug is not necessarily used to treat response condition

SCV000268408

Summary from all submissions

EthnicityOriginAffectedIndividualsFamiliesChromosomes testedNumber TestedFamily historyMethod
not providedgermlineyesnot providednot providednot providednot providednot providedcuration

Citations

PubMed

Variation in the gene encoding the serotonin 2A receptor is associated with outcome of antidepressant treatment.

McMahon FJ, Buervenich S, Charney D, Lipsky R, Rush AJ, Wilson AF, Sorant AJM, Papanicolaou GJ, Laje G, Fava M, Trivedi MH, Wisniewski SR, Manji H.

Am J Hum Genet. 2006 May;78(5):804-814. doi: 10.1086/503820. Epub 2006 Mar 20.

PubMed [citation]
PMID:
16642436
PMCID:
PMC1474035

Association of GRIK4 with outcome of antidepressant treatment in the STAR*D cohort.

Paddock S, Laje G, Charney D, Rush AJ, Wilson AF, Sorant AJ, Lipsky R, Wisniewski SR, Manji H, McMahon FJ.

Am J Psychiatry. 2007 Aug;164(8):1181-8.

PubMed [citation]
PMID:
17671280
See all PubMed Citations (10)

Details of each submission

From PharmGKB, SCV000268408.3

#EthnicityIndividualsChromosomes TestedFamily HistoryMethodCitations
1not providednot providednot providednot providedcuration PubMed (10)

Description

PharmGKB Level of Evidence 2B: Annotation for a variant-drug combination with moderate evidence of an association. The association must be replicated but there may be some studies that do not show statistical significance, and/or the effect size may be small.

#SampleMethodObservation
OriginAffectedNumber testedTissuePurposeMethodIndividualsAllele frequencyFamiliesCo-occurrences
1germlineyesnot providednot providednot providednot providednot providednot providednot provided

Last Updated: Mar 30, 2019

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